Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Penentuan Aktivitas Antioksidan Dan Kandungan Fenol Totalekstrak Daun Gendola (Basella Rubra Linn) Dan Daun Binahong (Anredera Cordifolia Stennis) Sebagai Kandidat Obat Herbal [PDF]
, 2014 - Gendola (Basella rubra Linn) and Binahong (Anredera cardifolia) are medicinal plant. Gendola and Binahong leaves widely used as traditional medicine for Indonesian people.The objectives of this research were to examine the antioxidant activity and the ...
Lukiati, B. (Betty)
core
Chemical and spectroscopic analysis of olive mill waste water during a biological treatment [PDF]
, 2007 The treatment of olive mill waste water was studied on the laboratory scale. Physico–chemical analyses showed the final products had a mean pH of 5.4 without neutralisation and 5.7 when lime was added to the process.
Bailly, Jean-René +5 more
core +5 more sources
Fruit ResearchPolyphenols are recognized as a class of compounds possessing a wide range of biological activities that provide numerous health benefits to humans. Apples are abundant in polyphenolic substances.
Qingshan Li +9 more
doaj +1 more source
Extra-virgin olive oil phenols block cell cycle progression and modulate chemotherapeutic toxicity in bladder cancer cells [PDF]
, 2016 Epidemiological data indicate that the daily consumption of extra‑virgin olive oil (EVOO), a common dietary habit of the Mediterranean area, lowers the incidence of certain types of cancer, in particular bladder neoplasm. The aim of the present study was
Coccia, Andrea +5 more
core +1 more source
Quantitative Analysis of Total Flavonoids and Total Phenolic Acids in Thirty Hypericum Taxa [PDF]
Natural Product Communications, 2013 The content of total flavonoids and total phenolic acids in the aerial parts of thirty Hypericum taxa collected over two consecutive seasons was investigated by spectrophotometric methods. All taxa examined contained flavonoids and phenolic acids in different quantities, although the differences between species and year's harvest were not found to be ...
Maleš, Željan +2 more
openaire +3 more sources