Results 101 to 110 of about 7,053,254 (292)

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao   +8 more
wiley   +1 more source

Total polyphenols and total flavonoids in three different extracts of leaves of Tithonia diversifolia (Hemsl.) A. Gray.

open access: yes, 2015
* = p< 0.001 vs aqueous extract;** = p< 0.005 vs aqueous extract.Total polyphenols and total flavonoids in three different extracts of leaves of Tithonia diversifolia (Hemsl.) A. Gray.
Ignazio Barbagallo (596876)   +9 more
core   +1 more source

Total polyphenols content in fruits of selected cultivars of strawberries in relation to concentrations of cadmium and lead in soil [PDF]

open access: yes, 2015
The key aim of our study was to define the correlation of total polyphenols contents in seven cultivars of strawberries (Clery, Sonata, Alba, Korona, Ázia juh, Anthea, Joly) grown in the parcels with exceeded levels of pseudo-total Cd and mobile Pb in ...
Trebichalský, Pavol   +5 more
core   +1 more source

Developing Metal–Polyphenol Network‐Based Single‐Protein Particle Encapsulation System for Sustained Release of Whey Protein to Mitigate Sarcopenia

open access: yesAdvanced Science, EarlyView.
Sarcopenia has emerged as a major health challenge in the aging population. Developing a sustained‐release system for whey protein may enhance its effectiveness in mitigating sarcopenia. Herein, a novel “single‐protein particle encapsulation” (SPPE) system is developed to protect whey protein and control its release.
Yafei Zhang   +11 more
wiley   +1 more source

Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte‐Mediated Fibrosis and Protecting Nucleus Pulposus Cells

open access: yesAdvanced Science, EarlyView.
The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma   +12 more
wiley   +1 more source

Effect of cultivar x ozone treatment interaction on the total polyphenols content and antioxidant activity of globe artichoke

open access: yesItalian Journal of Agronomy, 2015
Two globe artichoke cultivars (Violet de Provence and Apollo) were harvested at an experimental field in Sicily, immediately washed with ozonised water and stored in: i) normal atmosphere; ii) ozone-enriched atmosphere for 3 days and for the last 4 days ...
Sara Lombardo   +7 more
doaj   +1 more source

Metal–Phenolic Complexation Governs Soil Mineral Crystallinity to Enhance Crop Growth

open access: yesAdvanced Science, EarlyView.
A coordination‐driven, coprecipitation approach is presented to obtain polyphenolic‐incorporated minerals with tunable crystallinity, offering insights into how plants may influence soil mineral structures. Soil minerals can incorporate polyphenolic secondary metabolites and enhance plant nutrition by facilitating the formation of amorphous metal ...
Jong‐Rok Jeon   +10 more
wiley   +1 more source

Gardenia Fruit as a Novel Substrate for Kombucha Fermentation: Impacts on Physicochemical Properties, Bioactive Compounds, Metabolomic Profiles, and Sensory Acceptance

open access: yesFoods
Gardenia fruit, a medicinal and edible resource rich in bioactive compounds, faces several limitations, including low extraction efficiency, poor stability, and intense bitterness. In this study, gardenia fruit powder at varying concentrations (2.5%, 5.0%
Kaiyu Chen   +6 more
doaj   +1 more source

The potential role of dietary polyphenols in Parkinson’s disease [PDF]

open access: yes, 2011
Cumulative evidence now suggests that the abnormal aggregation of the neuronal protein alpha-synuclein is critically involved in the pathogenesis of synucleinopathies, of which Parkinson’s disease (PD) is the most prevalent. Development of neuropathology
Vassallo, Neville   +1 more
core  

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

open access: yesAdvanced Science, EarlyView.
This berberine‐loaded dual‐dynamically crosslinked nanogel integrates tannic acid‐zinc metal‐phenolic networks and carboxymethyl chitosan/aldehyde‐functionalized poly(ethylene glycol) dynamic Schiff base networks, achieving 1‐year colloidal and antioxidant stability, sustained corneal berberine exposure for 24 h to support convenient once‐daily dosing,
Yanru Xin   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy