Results 211 to 220 of about 16,454,265 (355)

Total Synthesis and Biological Evaluation of Leptosphaerone B and Derivatives of Microketide A. [PDF]

J Nat Prod
Köllen MF, Sieber SA.
europepmc   +1 more source

Total Synthesis of (+)-Pleuromutilin.

Journal of the American Chemical Society, 2018
Elliot P. Farney, S. Feng, Felix Schäfers, S. Reisman   +3 more
semanticscholar   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

An "Inside-Out" Strategy Enables a 14-Step Total Synthesis of Hispidospermidin. [PDF]

JACS Au
Amber C, Nakamura T, Amoako M, Settineri NS, Sarpong R.   +4 more
europepmc   +1 more source

Navigating the Chiral Pool in the Total Synthesis of Complex Terpene Natural Products.

Chemical Reviews, 2017
Zachary G Brill, Matthew L Condakes, Chi P. Ting, T. Maimone   +3 more
semanticscholar   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Total Synthesis of Aconicarmisulfonine A, a Sulfonated Diterpene Alkaloid. [PDF]

J Am Chem Soc
Ning S, Maimone TJ.
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Total Synthesis of Calyciphylline F. [PDF]

Angew Chem Int Ed Engl
Sato R, Sumida R, Inoue M, Kotaka R, Karanjit S, Namba K.   +5 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source