In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
ORWELL A FOST MAI BINE CONECTAT LA POLITICA BRITANICĂ DECÂT CHURCHILL [PDF]
Revista de Știinţe Politice şi Relaţii InternaţionaleThere is a degree of congruence between Orwell and Churchill, a theme which forms the basis of Thomas Ricks’ book, Churchill and Orwell. In the 1930s, both Churchill and Orwell were outsiders, pursuing an agenda which failed to capture the public ...
Manolache, Viorella, Browne, Ian
doaj
Îngropat în cer: Imre Kertész, Kadiș pentru copilul nenăscut [PDF]
Revista de Istorie și Teorie Literară, 2016 2002 Nobel Literature Prize Winner, Imre Kertész, in his novel Kaddish for an Unborn Child, configures a path of Jewishness as “reconceptualization of the future” caused by the traumatic postHolocaust historical circumstances.
Cristina Deutsch
doaj
Illiberal regimes in the perspective of comparative constitutionalism [PDF]
, 2017 Illiberal regimes are generally de ned as regimes in which neither democracy nor fundamental rights are granted, and in which rule of law is substantially disregarded. Instead of attempting a taxonomy, the article gives an account of their origins and of
Pinelli, Cesare
core
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
The last flight of F/O Tadeusz Stabrowski. Identification of the polish pilot. [PDF]
Front Genet, 2023 Lisman D +10 more
europepmc +1 more source
'A Balance of Power that Favors Freedom'. The Historical and Ideological Roots of the Neo-Conservative Persuasion [PDF]
The paper offers a genealogy of neoconservatism, concentrating on its ideological and historical foundations in the early 1970s. In the first part, it shows how neoconservatism represented a reaction to the crisis-real and perceived-the United States was
Mario del Pero
core
Countering destruction with spontaneity, redescription, and playfulness: A philosophical reading of Kross [PDF]
, 2017 This thesis focuses on a philosophical analysis of literature. The central question is: when making moral choices in a forced labor camp, what options remain?
Salura, Merily
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source