Results 81 to 90 of about 1,765,392 (245)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Exposure to a Titanium Dioxide Product Alters DNA Methylation in Human Cells

Nanomaterials
The safety of titanium dioxide (TiO2), widely used in foods and personal care products, has been of ongoing concern. Significant toxicity of TiO2 has been reported, suggesting a risk to human health.
Carlos Wells, Marta Pogribna, Arjun Sharmah, Angel Paredes, Beverly Word, Anil K. Patri, Beverly Lyn-Cook, George Hammons   +7 more
doaj   +1 more source

Chronic toxicity of inhaled thymol in lungs and respiratory tracts in mouse model. [PDF]

, 2019
Epinephrine HFA (Primatene® Mist) is a newly formulated asthma metered dose inhaler developed to replace the previous Primatene® Mist CFC. The formulation of Epinephrine HFA contains thymol, a substance recognized to be safe by the FDA.
Luo, Mary Z, Tashkin, Donald P, Xie, Kevin, Zhang, Jack Y   +3 more
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Discussion on common problems after introducing "reduction factor" into different working hour systems in occupational exposure assessment in GBZ 2.1—2019

环境与职业医学
Occupational exposure limits for hazardous agents in the workplace—Part 1: Chemical hazardous agents (GBZ 2.1—2019) has been implemented since April 1, 2020.
Ji HUANG, Pingning DUAN, Lifeng MAI, Songwen FU   +3 more
doaj   +1 more source

The ubiquitin-proteasome pathway in Huntington's disease. [PDF]

, 2008
The accumulation of mutant protein is a common feature of neurodegenerative disease. In Huntington's disease, a polyglutamine expansion in the huntingtin protein triggers neuronal toxicity.
Finkbeiner, Steven, Mitra, Siddhartha
core   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Interactions between Magnetic Nanowires and Living Cells : Uptake, Toxicity and Degradation

, 2011
We report on the uptake, toxicity and degradation of magnetic nanowires by NIH/3T3 mouse fibroblasts. Magnetic nanowires of diameters 200 nm and lengths comprised between 1 {\mu}m and 40 {\mu}m are fabricated by controlled assembly of iron oxide ({\gamma}
Armelle Baeza-Squiban, Auffan M., Berret J.-F., Brunner T. J., Cappallo N., Champion J. A., Chanteau B., Conner S. D., Denizot F., Dietrich Averbeck, Donaldson K., Doshi N., Dumortier H., Florence Niedergang, Fresnais J., Fresnais J., Fresnais J., Fung A. O., Goubault C., Gratton S. E. A., Hallstrom W., Hillaireau H., Hultgren A., Hurst S. J., Hussain S., Hélène Conjeaud, Jacquin M., Jean-François Berret, Johansson F., Kagan V. E., Kim J., Kuimova M. K., Leung K. C. F., Lewinski N., Lutz J.-F. o., Malak Safi, Marie-Alice Guedeau-Boudeville, Massart R., Minhao Yan, Nan A. J., Nicole Boggetto, Niedergang F., Petri-Fink A., Pisanic T. R., Rad A. M., Safi M., Sehgal A., Singh H., Singh N., Song M. M., Tanase M., Virginie Garnier-Thibaud   +51 more
core   +3 more sources

Recreational use, analysis and toxicity of tryptamines [PDF]

, 2015
The definition New psychoactive substances (NPS) refers to emerging drugs whose chemical structures are similar to other psychoactive compounds but not identical, representing a "legal" alternative to internationally controlled drugs.
Mannocchi, Giulio, Pantano, Flaminia, Romolo, Francesco Saverio, Tittarelli, Roberta   +3 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source