Results 1 to 10 of about 18,231 (173)
Emerging Fusarium and Alternaria Mycotoxins: Occurrence, Toxicity and Toxicokinetics [PDF]
Toxins, 2017 Emerging Fusarium and Alternaria mycotoxins gain more and more interest due to their frequent contamination of food and feed, although in vivo toxicity and toxicokinetic data are limited.
Sophie Fraeyman +3 more
doaj +4 more sources
Comparative Toxicokinetics and Biomarker Responses of Typical Psychiatric Pharmaceuticals in Daphnia magna [PDF]
ToxicsThe widespread availability and pseudo-persistence of typical psychiatric pharmaceuticals (PDs) can have serious impacts on aquatic ecosystems and even human health.
Haohan Yang +5 more
doaj +2 more sources
Hepatotoxicity Induced by Methyl Eugenol: Insights from Toxicokinetics, Metabolomics, and Gut Microbiota [PDF]
Current Issues in Molecular BiologyDue to continuous application as a flavoring agent in the pesticide, pharmaceutical, and food industries, methyl eugenol (ME) persists in the environment and causes deleterious impacts including cytotoxicity, genotoxicity, and liver damage.
Liang Chen +3 more
doaj +2 more sources
Toxicokinetics of a Single Oral Dose of Aflatoxin B1 in Plasma, Feces, and Urine of Male Donkeys [PDF]
ToxinsAflatoxin B1 (AFB1) is widely present in raw materials for food and feedstock, posing a significant threat to the health of humans and animals. This study explored the toxicokinetics of a single oral administration of AFB1 at a dose of 100 µg·kg−1 BW ...
Yulong Feng +9 more
doaj +2 more sources
Enterohepatic Recirculation-Mediated Reabsorption of Aristolochic Acid I: Revealed by Toxicokinetics and Metabolite Identification in Rats [PDF]
ToxicsAristolochic acid I (AAI) is widely recognized as a genotoxic and cytotoxic compound. To rationally propose detoxification strategies, it is essential to fully elucidate the in vivo disposition of AAI.
Lieyan Huang +5 more
doaj +2 more sources
Advances in Pharmacological Sciences, 2011 Kava is traditionally consumed by South Pacific islanders as a drink and became popular in Western society as a supplement for anxiety and insomnia. Kava extracts are generally well tolerated, but reports of hepatotoxicity necessitated an international ...
Anthony Rowe +2 more
doaj +3 more sources
Derivation of Human Toxicokinetic Parameters and Chemical-Specific Adjustment Factor of Citrinin Through a Human Intervention Trial and Hierarchical Bayesian Population Modeling [PDF]
ToxinsBackground: Citrinin (CIT) is a mycotoxin produced by various fungi contaminating stored cereals and fruits. While biomonitoring and food occurrence data indicate widespread exposure, its public health risks remain unclear due to the lack of human ...
Lia Visintin +5 more
doaj +2 more sources
Journal of Nanobiotechnology, 2021 The widespread use of nanomaterials (NMs) has raised concerns that exposure to them may introduce potential risks to the human body and environment. The liver is the main target organ for NMs.
Ting Sun +7 more
doaj +1 more source
Frontiers in Toxicology, 2022 Physiologically based kinetic (PBK) modeling has been increasingly used since the beginning of the 21st century to support dose selection to be used in preclinical and clinical safety studies in the pharmaceutical sector.
Engi Abdelhady Algharably +6 more
doaj +1 more source
Frontiers in Pediatrics, 2021 Colchicine poisoning is associated with a poor prognosis, especially when leading to shock and multi-organ failure, and management is limited to supportive care, including multiple-dose activated charcoal.
Maria Pérez Marín +9 more
doaj +1 more source