Results 11 to 20 of about 18,256 (198)
Species Sensitivity to Toxic Substances: Evolution, Ecology and Applications
Frontiers in Environmental Science, 2020 Because it is only possible to test chemicals for effects on a restricted range of species and exposure scenarios, ecotoxicologists are faced with a significant challenge of how to translate the measurements in model species into predictions of impacts ...
David Spurgeon +4 more
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Frontiers in Pharmacology, 2023 Introduction: Recombinant human fibroblast growth factor 21 (FGF-21) is a potential therapeutic agent for multiple metabolic diseases. However, little is known about the toxicokinetic characteristics of FGF-21.Methods: In the present study, we ...
Chao Lu +17 more
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The formalin test does not probe inflammatory pain but excitotoxicity in rodent skin
Physiological Reports, 2022 The most widely used formalin test to screen antinociceptive drug candidates is still apostrophized as targeting inflammatory pain, in spite of strong opposing evidence published.
Tal Hoffmann +12 more
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Toxins, 2022 Cytochrome P-450 (CYP) enzymes have a key role in the metabolism of xenobiotics of food origin, and their highly polymorphic nature concurs with the diverse inter-individual variability in the toxicokinetics (TK) and toxicodynamics (TD) of food chemicals.
Jean Lou C. M. Dorne +5 more
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The In Vivo and In Vitro Toxicokinetics of Citreoviridin Extracted from Penicillium citreonigrum
Toxins, 2019 Citreoviridin (CTVD), a mycotoxin called yellow rice toxin, is reported to be related to acute cardiac beriberi; however, its toxicokinetics remain unclear.
Yosuke Uchiyama +5 more
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Human Vaccines & Immunotherapeutics, 2023 A humanized monoclonal antibody h2E2 designed to bind cocaine with high affinity, specificity, and a long half-life (~7 d in rats) is being developed as a treatment for cocaine use disorder.
Rose P. Webster +2 more
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Toxicokinetics and bioconcentration of polycyclic aromatic hydrocarbons in freshwater isopods [PDF]
, 1999 A novel method based on a first-order two-compartment model was used to determine the bioconcentration and toxicokinetic rate constants of six different polycyclic aromatic hydrocarbons (PAHs) in the freshwater isopod Asellus aquaticus, a common species ...
Cid Montañés, J.F., Hattum, A.G.M. van
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Metabolic profile, bioavailability and toxicokinetics of zearalenone-14-glucoside in rats after oral and intravenous administration by liquid chromatography high-resolution mass spectrometry and tandem mass spectrometry [PDF]
, 2019 Zearalenone-14-glucoside (ZEN-14G), a key modified mycotoxin, has attracted a great deal of attention due to the possible conversion to its free form of zearalenone (ZEN) exerting toxicity.
De Boevre, Marthe +9 more
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Frontiers in Pharmacology, 2016 Though protamine sulfate is the only approved antidote of unfractionated heparin (UFH), yet may produce life threatening side effects such as systemic hypotension, catastrophic pulmonary vasoconstriction or allergic reactions.
Emilia eSokolowska +10 more
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A geometric characterization of $c$-optimal designs for heteroscedastic regression [PDF]
, 2008 We consider the common nonlinear regression model where the variance, as well as the mean, is a parametric function of the explanatory variables. The $c$-optimal design problem is investigated in the case when the parameters of both the mean and the ...
Dette, Holger, Holland-Letz, Tim
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