Results 41 to 50 of about 160,346 (305)

The C30-Modulation of Betulinic Acid Using 1,2,4-Triazole: A Promising Strategy for Increasing Its Antimelanoma Cytotoxic Potential

Molecules, 2022
Cancer, in all its types and manifestations, remains one of the most frequent causes of death worldwide; an important number of anticancer drugs have been developed from plants, fungi and animals, starting with natural compounds that were later ...
Gabriela Nistor, Marius Mioc, Alexandra Mioc, Mihaela Balan-Porcarasu, Roxana Racoviceanu, Alexandra Prodea, Andreea Milan, Roxana Ghiulai, Alexandra Semenescu, Cristina Dehelean, Codruța Șoica   +10 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Toxicological safety evaluation of freeze-dried Protaetia brevitarsis larva powder

Toxicology Reports, 2018
White-spotted flower chafer (Protaetia brevitarsis) is an edible insect and its larva was used as a traditional Asian medicine. It’s a promising material as a novel food source because of its nutritional components.
Jung-Ho Noh, Ji-Seong Jeong, Sang-Jin Park, Eun-Young Yun, Jae Sam Hwang, Ji-Young Kim, Kyung-Jin Jung, Hee Jin Park, Hwa-Young Son, Kyoung-Sik Moon   +9 more
doaj   +1 more source

Adaptability of AI for safety evaluation in regulatory science: A case study of drug-induced liver injury

Frontiers in Artificial Intelligence, 2022
Artificial intelligence (AI) has played a crucial role in advancing biomedical sciences but has yet to have the impact it merits in regulatory science. As the field advances, in silico and in vitro approaches have been evaluated as alternatives to animal
Skylar Connor, Ting Li, Ruth Roberts, Ruth Roberts, Shraddha Thakkar, Zhichao Liu, Weida Tong   +6 more
doaj   +1 more source

Semiconductor Electronic Label-Free Assay for Predictive Toxicology. [PDF]

, 2016
While animal experimentations have spearheaded numerous breakthroughs in biomedicine, they also have spawned many logistical concerns in providing toxicity screening for copious new materials. Their prioritization is premised on performing cellular-level
Chui, Chi On, Ji, Zhaoxia, Mao, Yufei, Meng, Huan, Shin, Kyeong-Sik, Wang, Xiang   +5 more
core   +2 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Stability Profile and Clinical Evaluation of an Innovative Hydrogel Containing Polymeric Micelles as Drug Delivery Systems with Oregano Essential Oil against Fibroepithelial Polyps

Pharmaceuticals, 2023
Skin tags, also known as fibroepithelial polyps (FPs) or acrochordons, are soft, pigmented excrescences, with a prevalence of 50–60% in the population, occurring especially in the fourth decade of life. To date, FPs have been efficiently eliminated using
Larisa Bora, Andrada Iftode, Ana Maria Muț, Lavinia Lia Vlaia, Gheorghe-Emilian Olteanu, Delia Muntean, Cristina Adriana Dehelean, Valentina Buda, Georgeta Hermina Coneac, Corina Danciu   +9 more
doaj   +1 more source

Comparative Analysis Of Zebrafish And Planarian Model Systems For Developmental Neurotoxicity Screens Using An 87-Compound Library [PDF]

, 2019
There is a clear need to establish and validate new methodologies to more quickly and efficiently screen chemicals for potential toxic effects, particularly on development. The emergence of alternative animal systems for rapid toxicology screens presents
Collins, Eva-Maria S., Hagstrom, D., Tanguay, R., Truong, L., Zhang, S.   +4 more
core   +1 more source

An overview of anti-diabetic plants used in Gabon: Pharmacology and Toxicology [PDF]

, 2018
© 2017 Elsevier B.V. All rights reserved.Ethnopharmacological relevance: The management of diabetes mellitus management in African communities, especially in Gabon, is not well established as more than 60% of population rely on traditional treatments as ...
A. Souza, Abdelgadir, Abdu-Aguye, Abdulrazaq, Abubakar, Adebayo, Adedoyin, Adelusi, Ademuyiwa, Adeneye, Adeneye, Adeneye, Adeneye, Aderibigbe, Adeyemi, Adisa, Adler, Agbor, Agnaniet, Agunbiabe, Agyare, Ajaiyeoba, Ajaiyoeba, Ajao, Ajayi, Akah, Akash, Akinloye, Akpanyung, Aladodo, Alaribe, Amole, Anaduaka, Anosike, Anowi, Anowi, Antia, Anyanwu, Apers, Areola, Arthur, Asadu, Asha, Ashraf, Asolkar, Assob, Asuquo, Atangwho, Atawodi, Atawodi, Aw, Awah, Awe, Aziba, B. Bading Taika, Balasubramanian, Bamisaye, Bapna, Bardi, Bayan, Bella, Ben-Chioma, Bera, Biney, Bisong, Brantley, Calapai, Campbell, Campbell-Tofte, Capasso, Chika, Chokshi, Chris-Ozoko, Coolborn, Coria-Téllez, Da-Costa-Rocha, Dadzeasah, Dahake, Das, Dhanabalan, Djeussi, Djimeli, Djomeni, Djomeni Dzeufiet, Effiong, Effiong, Effo, Eidi, Ejike, El-Demerdash, Elufioye, Elumalai, Eluwa, Eneh, Erharuyi, Erhirhie, Eteng, Etuk, Ewenighi, Ewere, Eyong, Eze, Ezeasor, Ezejindu, Ezejiofor, Ezeokeke, Ezike, Ezuruike, Fang-Chui, Farzaei, Fernand, Ferreira, Feuya Tchouya, Feuya Tchouya, Fongang, Fred-Jaiyesimi, Gandhare, Ganesh, Gbadegesin, Gboeloh, Gemede, Ghani, Ghiware, Gomez-Flores, Gondi, Goutarel, Gupta, Gutierrez, H.P. Bourobou Bourobou, Halim, Hamzah, Hansen, Helfer, Hossain, Houghton, Houël, Huang, Huang, Husain, Husin, Ibibia, Igbe, Igboasoiyi, Ilodigwe, Ilodigwe, Ilusanya, Inya-Agha, Iroanya, Irondi, Irondi, Ishola, Iwu, Iyamah, Jawonisi, Juárez-Rojop, Juárez-Rojop, Kadima, Kaiser, Kamagate, Kamboj, Karimi, Karioti, Kathirvel, Kazeem, Kazeem, Kengni, Kengni, Khodabakhsh, Kolawole, Kouakou, Koudou, Kouitcheu Mabeku, Krishna, Kubilienė, Kuete, Kuete, Kuete, Kulkarni, Kumar, Kumar, Kumar, Kupchan, L. Lione, L.S. MacKenzie, Lakshmi, Lamidi, Lawal, Lawal, Laxane, Lee, Li, Lima, Ludvik, Ludvik, Luka, M. Bouckandou, Mabeku, Madingou, Madingou, Malviya, Manga, Maniyar, Manjur, Manvitha, Mathur, Maurya, Mačiulaitis, Mbiantcha, Mebale, Mengome, Midawa, Miranda-Osorio, Mishra, Miura, Mohamed, Mohammed, Mohammed, Mohammed, Mohammed, Momoh, Montasser, Muhammad, Muhammad, Muhammad, Muhammad, Muttaka, Nabukenya, Nakavuma, Naseri, Naskar, Navghare, Ndam, Nessa, Ngoc, Ngondi, Ngondi, Ngueguim, Ngueguim, Nishimura, Niyonzima, Nkono Ya Nkono, Nkono Ya Nkono, Ntyonga-Pono, Nwamarah, Nweze, Nwodo, Nwokocha, Nyunaï, Nyunaï, N’doua, N’guessan, N’Guessan, Obiang, Obiudu, Ocho-Anin Atchibri, Oduola, Oduola, Ofusori, Ogbonnia, Ogunrinola, Ojewole, Ojewole, Ojewunmi, Ojewunmi, Ojiako, Okeke, Okokon, Okokon, Okokon, Okolie, Okolo, Okonkwo, Olajide, Olaleye, Olatokunboh, Olivier, Olowu, Olubomehin, Ombra, Omodamiro, Omonkhua, Ong, Onyekwe, Osabede, Osadebe, Osigwe, Ouédraogo, Oyewusi j, Ozsoy-Sacan, Padilla-Camberos, Palaksha, Panda, Panda, Parle, Passoni, Patel, Patil, Ping, Pochapski, Pour, Pérez, Rajesh, Raji, Rauf, Ravi, Renjith, Rong, Rosemary, Roy, Sabitha, Sagnia, Santas, Satyaprakash, Saxena, Seung, Shah, Sharma, Sharma, Sharma, Shittu, Silva, Singh, Singh, Sio, Somova, Souza, Sowemimo, Sudhakar, Sule, Sunday, Sunday, Suryawanshi, Sutar, Swargiary, Swathi, Taj Eldin, Talreja, Tan Paul, Tanayen, Tchamadeau, Teugwa, Thongsom, Titanji, Tjeck, Togola, Toma, Toma, Trabelsi, Uchechi, Ufelle, Umoh, Vannamalar, Varghese, Varghese, Vashishtha, Verma, Verma, Vijayalakshmi, Vikram, Vliet, Wang, Wang, Wauthoz, Woode, Yakubu, Yasir, Yeap, Yessoufou, Yokozawa, Yousuf, Yu, Zakiah, Zhang, Zhao, Zheng   +374 more
core   +4 more sources

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source