Results 21 to 30 of about 160,346 (305)

Structural Investigation of Betulinic Acid Plasma Metabolites by Tandem Mass Spectrometry

Molecules, 2022
Betulinic acid (BA) has been extensively studied in recent years mainly for its antiproliferative and antitumor effect in various types of cancers.
Roxana Ghiulai, Marius Mioc, Roxana Racoviceanu, Alexandra Prodea, Andreea Milan, Dorina Coricovac, Cristina Dehelean, Ștefana Avram, Alina D. Zamfir, Cristian V. A. Munteanu, Viviana Ivan, Codruța Şoica   +11 more
doaj   +1 more source

Toxicological Study Employing Repeated Doses of Garcinielliptone FC, a Polyisoprenylated-Benzophenone Isolated from Seed of Platonia Insignis Mart [PDF]

, 2015
The major constituent from the hexane extract of the seeds of P. insignis is GFC (garcinielliptone FC). Doses of 25, 50and 75 mg/kg of GFC were aseptically suspended in 0.05% Tween 80 dissolved in 0.9% saline (vehicle) and orally administered for30, 90 ...
da Costa Júnior, Joaquim S., David, Jorge M., Faillace, Martín Sebastián, Falcão Ferraz, Alexandre de B., Filho, José Carlos C. L. S., Freitas, Rivelilson M., Peláez, Walter José, Silva, Ana P.   +7 more
core   +1 more source

Safety evaluation of the food enzyme pullulanase from genetically modified Bacillus subtilis strain NZYM-AK [PDF]

, 2017
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Aguilera-Gómez, Margarita, Bolognesi, Claudia, Castle, Laurence, Chesson, Andrew, Cravedi, Jean-Pierre, EFSA Panel on Food Contact Materials Enzymes, Flavourings and Processing Aids (CEF), Engel, Karl-Heinz, Fowler, Paul, Franz, Roland, Glandorf, Boet, Grob, Konrad, Gürtler, Rainer, Herman, Lieve, Husøy, Trine, Jany, Klaus-Dieter, Kovalkovičová, Natália, Kärenlampi, Sirpa, Maia, Joaquim, Marcon, Francesca, Mennes, Wim, Milana, Maria Rosaria, Penninks, André, Silano, Vittorio, Smith, Andrew, Tavares Poças, Maria de Fátima, Tlustos, Christina, Wölfle, Detlef, Zorn, Holger, Zugravu, Corina-Aurelia, Želježic, Davor   +29 more
core   +3 more sources

Safety assessment of the substance dimethyl carbonate for use in food contact materials [PDF]

, 2017
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Bolognesi, Claudia, Castle, Laurence, Cravedi, Jean-Pierre, Croera, Cristina, EFSA Panel on Food Contact Materials Enzymes, Flavourings and Processing Aids (CEF), Engel, Karl-Heinz, Fowler, Paul, Franz, Roland, Grob, Konrad, Gürtler, Rainer, Husøy, Trine, Kolf-Clauw , Martine, Kärenlampi, Sirpa, Lampi, Eugenia, Mennes, Wim, Milana, Maria Rosaria, Penninks, André, Silano, Vittorio, Smith, Andrew, Svensson, Kettil, Tavares Poças, Maria de Fátima, Tlustos, Christina, Wölfle, Detlef, Zorn, Holger, Zugravu, Corina-Aurelia   +24 more
core   +3 more sources

The Importance of Nutraceuticals in COVID-19: What’s the Role of Resveratrol?

Molecules, 2022
Since COVID-19 has affected global public health, there has been an urgency to find a solution to limit both the number of infections, and the aggressiveness of the disease once infected.
Elisa Domi, Malvina Hoxha, Entela Kolovani, Domenico Tricarico, Bruno Zappacosta   +4 more
doaj   +1 more source

A rapid stability-indicating, fused-core HPLC method for simultaneous determination of β-artemether and lumefantrine in anti-malarial fixed dose combination products [PDF]

, 2013
Background: Artemisinin-based fixed dose combination (FDC) products are recommended by World Health Organization (WHO) as a first-line treatment. However, the current artemisinin FDC products, such as beta-artemether and lumefantrine, are inherently ...
Bracke, Nathalie, Burvenich, Christian, D'Hondt, Matthias, De Spiegeleer, Bart, Duchateau, Luc, Peremans, Kathelijne, Vandercruyssen, Kirsten, Wega, Sultan Suleman, Wynendaele, Evelien   +8 more
core   +2 more sources

Sex-Related Differences in the Pharmacological Response in SARS-CoV-2 Infection, Dyslipidemia, and Diabetes Mellitus: A Narrative Review

Pharmaceuticals, 2023
Pharmacological responses vary by sex in several illnesses. This narrative review summarizes sex variations in pharmaceutical response in SARS-CoV-2 infection, dyslipidemia, and diabetes mellitus.
Adelina Lombrea, Mirabela Romanescu, Narcisa Jianu, Minodora Andor, Maria Suciu, Dana Emilia Man, Corina Danciu, Cristina Adriana Dehelean, Valentina Buda   +8 more
doaj   +1 more source

Safety evaluation of the food enzyme endo-1,4-β-xylanase from genetically modified Aspergillus niger strain XYL [PDF]

, 2017
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Aguilera-Gomez, Margarita, Andryszkiewicz, Magdalena, Arcella, Davide, Bolognesi, Claudia, Castle, Laurence, Chesson, Andrew, Cravedi, Jean-Pierre, de Fátima Tavares Poças, Maria, EFSA Panel on Food Contact Materials Enzymes, Flavourings and Processing Aids (CEF), Engel, Karl-Heinz, Fowler, Paul, Franz, Roland, Glandorf, Boet, Grob, Konrad, Gürtler, Rainer, Hermann, Lieve, Husøy, Trine, Jany, Klaus-Dieter, Kovalkovicova, Natalia, Kärenlampi, Sirpa, Liu, Yi, Marcon, Francesca, Mennes, Wim, Milana, Maria Rosaria, Penninks, André, Silano, Vittorio, Smith, Andrew, Tlustos, Christina, Wölfle, Detlef, Zorn, Holger, Zugravu, Corina-Aurelia, Želježic, Davor   +31 more
core   +3 more sources

Permitted daily exposure for diisopropyl ether as a residual solvent in pharmaceuticals [PDF]

, 2018
Solvents can be used in the manufacture of medicinal products provided their residual levels in the final product comply with the acceptable limits based on safety data.
Evandri, Maria Grazia, Romanelli, Luca
core   +1 more source

Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions

Particle and Fibre Toxicology, 2017
Background As nanoparticles (NPs) become more prevalent in the pharmaceutical industry, questions have arisen from both industry and regulatory stakeholders about the long term effects of these materials. This study was designed to evaluate whether gold (
James L. Weaver, Grainne A. Tobin, Taylor Ingle, Simona Bancos, David Stevens, Rodney Rouse, Kristina E. Howard, David Goodwin, Alan Knapton, Xiaohong Li, Katherine Shea, Sharron Stewart, Lin Xu, Peter L. Goering, Qin Zhang, Paul C. Howard, Jessie Collins, Saeed Khan, Kidon Sung, Katherine M. Tyner   +19 more
doaj   +1 more source