Results 1 to 10 of about 14,095 (158)

Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin–antitoxin system [PDF]

eLife, 2023
Many bacteria encode multiple toxin–antitoxin (TA) systems targeting separate, but closely related, cellular functions. The toxin of the Escherichia coli hipBA system, HipA, is a kinase that inhibits translation via phosphorylation of glutamyl-tRNA ...
René L Bærentsen, Stine V Nielsen, Ragnhild B Skjerning, Jeppe Lyngsø, Francesco Bisiak, Jan Skov Pedersen, Kenn Gerdes, Michael A Sørensen, Ditlev E Brodersen   +8 more
doaj   +3 more sources

The Haemophilus influenzae HipBA toxin–antitoxin system adopts an unusual three-component regulatory mechanism [PDF]

IUCrJ, 2022
Type II toxin–antitoxin (TA) systems encode two proteins: a toxin that inhibits cell growth and an antitoxin that neutralizes the toxin by direct intermolecular protein–protein interactions.
Ji Sung Koo, Sung-Min Kang, Won-Min Jung, Do-Hee Kim, Bong-Jin Lee   +4 more
doaj   +2 more sources

PrrT/A, a Pseudomonas aeruginosa Bacterial Encoded Toxin-Antitoxin System Involved in Prophage Regulation and Biofilm Formation [PDF]

Microbiology Spectrum, 2022
Toxin-antitoxin (TA) systems are genetic modules that consist of a stable protein-toxin and an unstable antitoxin that neutralizes the toxic effect. In type II TA systems, the antitoxin is a protein that inhibits the toxin by direct binding.
Esther Shmidov, Ilana Lebenthal-Loinger, Shira Roth, Sarit Karako-Lampert, Itzhak Zander, Sivan Shoshani, Amos Danielli, Ehud Banin   +7 more
doaj   +2 more sources

Understanding the physiological role and cross-interaction network of VapBC35 toxin-antitoxin system from Mycobacterium tuberculosis [PDF]

Communications Biology
The VapBC toxin-antitoxin (TA) system, composed of VapC toxin and VapB antitoxin, has gained attention due to its relative abundance in members of the M. tuberculosis complex.
Neelam Singh, Gopinath Chattopadhyay, Niranjana Sri Sundaramoorthy, Raghavan Varadarajan, Ramandeep Singh   +4 more
doaj   +2 more sources

Microcystis aeruginosa msoT1/msoA1 Locus Displays Features of a Type I Toxin–Antitoxin System [PDF]

Toxins
Type I toxin–antitoxin (TA) systems consist of a protein toxin that exerts a cytostatic or cytotoxic effect and an antisense RNA antitoxin that prevents translation of the toxin.
Matija Ruparčič, Marko Dolinar
doaj   +2 more sources

Association between toxin-antitoxin system mutations and global transmission of MDR-TB [PDF]

BMC Infectious Diseases
Background The emergence of Multidrug-Resistant Tuberculosis (MDR-TB) poses a significant threat to global tuberculosis control efforts. This study aimed to examine the influence of mutations in Toxin-Antitoxin system genes on the global transmission of ...
Yameng Li, Yang Shao, Yifan Li, Xianglong Kong, Ningning Tao, Yawei Hou, Tingting Wang, Yingying Li, Yao Liu, Huaichen Li   +9 more
doaj   +2 more sources

A phage-encoded RNA-binding protein inhibits the antiviral activity of a toxin-antitoxin system. [PDF]

Nucleic Acids Res, 2023
Guegler CK, Teodoro GIC, Srikant S, Chetlapalli K, Doering CR, Ghose DA, Laub MT.   +6 more
europepmc   +3 more sources

Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila [PDF]

Nature Communications, 2022
Here, the authors demonstrate that the Legionella pneumophila T4SS effector protein Lpg2370 is a Ser/Thr kinase and a toxin of a tripartite HipBST toxin-antitoxin (TA) system.
Xiangkai Zhen, Yongyu Wu, Jinli Ge, Jiaqi Fu, Le Ye, Niannian Lin, Zhijie Huang, Zihe Liu, Zhao-qing Luo, Jiazhang Qiu, Songying Ouyang   +10 more
doaj   +2 more sources

Structural insights into the PrpTA toxin-antitoxin system in Pseudoalteromonas rubra. [PDF]

Front Microbiol, 2022
Wang C, Niu C, Hidayatullah KM, Xue L, Zhu Z, Niu L.   +5 more
europepmc   +2 more sources

Rapid Identification of Secondary Structure and Binding Site Residues in an Intrinsically Disordered Protein Segment

Frontiers in Genetics, 2021
Mycobacterium tuberculosis harbours nine toxin-antitoxin (TA) systems of the MazEF family. MazEF TA modules are of immense importance due to the perceived role of the MazF toxin in M. tuberculosis persistence and disease.
Soumyanetra Chandra, Gopinath Chattopadhyay, Raghavan Varadarajan   +2 more
doaj   +1 more source