Results 11 to 20 of about 24,156 (244)

Modeling sRNA-Regulated Plasmid Maintenance. [PDF]

PLoS ONE, 2017
We study a theoretical model for the toxin-antitoxin (hok/sok) mechanism for plasmid maintenance in bacteria. Toxin-antitoxin systems enforce the maintenance of a plasmid through post-segregational killing of cells that have lost the plasmid.
Chen Chris Gong, Stefan Klumpp
doaj   +4 more sources

An oxygen-sensitive toxin–antitoxin system [PDF]

Nature Communications, 2016
Classical toxin–antitoxin systems in bacteria are based on silencing of a toxin by an antitoxin that, when inactivated, releases the toxin, resulting in a change in metabolism. Here, the authors characterize an oxygen-sensitive toxin–antitoxin system and
Oriol Marimon, João M. C. Teixeira, Tiago N. Cordeiro, Valerie W. C. Soo, Thammajun L. Wood, Maxim Mayzel, Irene Amata, Jesús García, Ainara Morera, Marina Gay, Marta Vilaseca, Vladislav Yu Orekhov, Thomas K. Wood, Miquel Pons   +13 more
doaj   +8 more sources

Applications of toxin-antitoxin systems in synthetic biology

Engineering Microbiology, 2023
Toxin-antitoxin (TA) systems are ubiquitous in bacteria and archaea. Most are composed of two neighboring genetic elements, a stable toxin capable of inhibiting crucial cellular processes, including replication, transcription, translation, cell division ...
Jianzhong Lin, Yunxue Guo, Jianyun Yao, Kaihao Tang, Xiaoxue Wang   +4 more
doaj   +3 more sources

Toxin-Antitoxin Systems as Multilevel Interaction Systems [PDF]

Toxins, 2014
Toxin-antitoxin (TA) systems are small genetic modules usually composed of a toxin and an antitoxin counteracting the activity of the toxic protein. These systems are widely spread in bacterial and archaeal genomes.
Nathalie Goeders, Laurence Van Melderen
doaj   +4 more sources

Unrelated toxin–antitoxin systems cooperate to induce persistence [PDF]

Journal of The Royal Society Interface, 2015
Persisters are drug-tolerant bacteria that account for the majority of bacterial infections. They are not mutants, rather, they are slow-growing cells in an otherwise normally growing population. It is known that the frequency of persisters in a population is correlated with the number of toxin–antitoxin systems in the organism.
Fasani, Rick A, Savageau, Michael A
openaire   +7 more sources

Toxin-Antitoxin Systems in Pathogenic Bacteria [PDF]

Toxins, 2021
Toxin–antitoxin (TA) systems, which are ubiquitously present in plasmids, bacterial and archaeal genomes, are classified as types I to VI, according to the nature of the antitoxin and to the mode of toxin inhibition [...]
Juan C. Alonso
  +9 more sources

RNA Regulated Toxin-Antitoxin Systems in Pathogenic Bacteria [PDF]

Frontiers in Cellular and Infection Microbiology, 2021
The dynamic host environment presents a significant hurdle that pathogenic bacteria must overcome to survive and cause diseases. Consequently, these organisms have evolved molecular mechanisms to facilitate adaptation to environmental changes within the ...
David D. Sarpong, David D. Sarpong, David D. Sarpong, Erin R. Murphy, Erin R. Murphy, Erin R. Murphy   +5 more
doaj   +3 more sources

Keeping the wolves at bay: antitoxins of prokaryotic type II toxin-antitoxin systems [PDF]

Frontiers in Molecular Biosciences, 2016
In their initial stages of discovery, prokaryotic toxin-antitoxin (TA) systems were confined to bacterial plasmids where they function to mediate the maintenance and stability of usually low- to medium-copy number plasmids through the post-segregational ...
Wai Ting eChan, Manuel eEspinosa, Chew Chieng eYeo   +2 more
doaj   +5 more sources

A plasmid-encoded inactive toxin-antitoxin system MtvT/MtvA regulates plasmid conjugative transfer and bacterial virulence in Pseudomonas aeruginosa. [PDF]

Nucleic Acids Res
Li M, Guo H, Wang L, Tao R, Song G, Cao L, Yan W, Wu Z, Liu Q, Chen Y, Gong L, Wang T, Zhang Y.   +12 more
europepmc   +2 more sources

Toxin–antitoxin systems [PDF]

Mobile Genetic Elements, 2013
Toxin-antitoxin (TA) systems are small genetic elements composed of a toxin gene and its cognate antitoxin. The toxins of all known TA systems are proteins while the antitoxins are either proteins or non-coding RNAs. Based on the molecular nature of the antitoxin and its mode of interaction with the toxin the TA modules are currently grouped into five ...
Unterholzner, Simon J, Poppenberger, Brigitte, Rozhon, Wilfried   +2 more
openaire   +2 more sources