Results 21 to 30 of about 14,160 (138)

TasA-tasB, a new putative toxin-antitoxin (TA) system from Bacillus thuringiensis pGI1 plasmid is a widely distributed composite mazE-doc TA system

BMC Genomics, 2006
Background Post-segregational killing systems are present in a large variety of microorganisms. When found on plasmids, they are described as addiction systems that act to maintain the plasmid during the partitioning of the cell.
Mahillon Jacques, Fico Sarah
doaj   +1 more source

RNA Regulated Toxin-Antitoxin Systems in Pathogenic Bacteria

Frontiers in Cellular and Infection Microbiology, 2021
The dynamic host environment presents a significant hurdle that pathogenic bacteria must overcome to survive and cause diseases. Consequently, these organisms have evolved molecular mechanisms to facilitate adaptation to environmental changes within the ...
David D. Sarpong, David D. Sarpong, David D. Sarpong, Erin R. Murphy, Erin R. Murphy, Erin R. Murphy   +5 more
doaj   +1 more source

Functional Characterization of the mazEF Toxin-Antitoxin System in the Pathogenic Bacterium Agrobacterium tumefaciens

Microorganisms, 2021
Agrobacterium tumefaciens is a pathogen of various plants which transfers its own DNA (T-DNA) to the host plants. It is used for producing genetically modified plants with this ability.
Wonho Choi, Yoshihiro Yamaguchi, Ji-Young Park, Sang-Hyun Park, Hyeok-Won Lee, Byung-Kwan Lim, Michael Otto, Masayori Inouye, Min-Ho Yoon, Jung-Ho Park   +9 more
doaj   +1 more source

HigB1 Toxin in Mycobacterium tuberculosis Is Upregulated During Stress and Required to Establish Infection in Guinea Pigs

Frontiers in Microbiology, 2021
The extraordinary expansion of Toxin Antitoxin (TA) modules in the genome of Mycobacterium tuberculosis has received significant attention over the last few decades.
Arun Sharma, Kalpana Sagar, Kalpana Sagar, Neeraj Kumar Chauhan, Balaji Venkataraman, Nidhi Gupta, Tannu Priya Gosain, Nikhil Bhalla, Ramandeep Singh, Amita Gupta, Amita Gupta   +10 more
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Dynamics-Based Regulatory Switches of Type II Antitoxins: Insights into New Antimicrobial Discovery

Antibiotics, 2023
Type II toxin-antitoxin (TA) modules are prevalent in prokaryotes and are involved in cell maintenance and survival under harsh environmental conditions, including nutrient deficiency, antibiotic treatment, and human immune responses. Typically, the type
Ki-Young Lee, Bong-Jin Lee
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Charged Amino Acids Contribute to ZorO Toxicity

Toxins, 2022
Chromosomally encoded toxin-antitoxin systems have been increasingly identified and characterized across bacterial species over the past two decades. Overproduction of the toxin gene results in cell growth stasis or death for the producing cell, but co ...
Bikash Bogati, Selene F. H. Shore, Thomas D. Nipper, Oana Stoiculescu, Elizabeth M. Fozo   +4 more
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Expression, Purification, and Functional Analysis of Novel RelE Operon from X. nematophila

The Scientific World Journal, 2014
Bacterial toxin-antitoxin (TA) complexes induce programmed cell death and also function to relieve cell from stress by various response mechanisms. Escherichia coli RelB-RelE TA complex consists of a RelE toxin functionally counteracted by RelB antitoxin.
Jitendra Singh Rathore, Lalit Kumar Gautam   +1 more
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RHS-elements function as type II toxin-antitoxin modules that regulate intra-macrophage replication of Salmonella Typhimurium.

PLoS Genetics, 2020
RHS elements are components of conserved toxin-delivery systems, wide-spread within the bacterial kingdom and some of the most positively selected genes known. However, very little is known about how Rhs toxins affect bacterial biology.
Magnus Stårsta, Disa L Hammarlöf, Marcus Wäneskog, Susan Schlegel, Feifei Xu, Arvid Heden Gynnå, Malin Borg, Sten Herschend, Sanna Koskiniemi   +8 more
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Evaluating the Potential for Cross-Interactions of Antitoxins in Type II TA Systems

Toxins, 2020
The diversity of Type-II toxin–antitoxin (TA) systems in bacterial genomes requires tightly controlled interaction specificity to ensure protection of the cell, and potentially to limit cross-talk between toxin–antitoxin pairs of the same family of TA ...
Chih-Han Tu, Michelle Holt, Shengfeng Ruan, Christina Bourne   +3 more
doaj   +1 more source

Viral evasion of a bacterial suicide system by RNA-based molecular mimicry enables infectious altruism.

PLoS Genetics, 2012
Abortive infection, during which an infected bacterial cell commits altruistic suicide to destroy the replicating bacteriophage and protect the clonal population, can be mediated by toxin-antitoxin systems such as the Type III protein-RNA toxin-antitoxin
Tim R Blower, Terry J Evans, Rita Przybilski, Peter C Fineran, George P C Salmond   +4 more
doaj   +1 more source