Results 121 to 130 of about 1,799 (138)

mTORC1 pathway activity biases cell fate choice. [PDF]

Sci Rep
Wang Y, Papayova M, Warren E, Pears CJ.
europepmc   +1 more source

Advances in astrocytic calcium signaling research. [PDF]

Front Cell Neurosci
Chen Y, Ye Y, Jia J, Long B, Dou T, Yan X.   +5 more
europepmc   +1 more source

Lysosomal calcium signalling contributes to the acute α-adrenergic response via calcium-stimulated adenylyl cyclase 1 and 8

Akerman E, Capel RA, Read M, Song Q, Bose SJ, Calamaio S, Aston D, Koschinski A, Lloyd S, Bell L, Rashbrook VS, Keller M, Bracher F, Potter BV, Rivolta I, Galione A, Sparrow DB, Conti A, Terrar DA, Zaccolo M, Burton RA.   +20 more
europepmc   +1 more source

Optical profiling of autonomous Ca2+ nanodomains generated by lysosomal TPC2 and TRPML1 [PDF]

Cell Calcium, 2023
Multiple families of Ca2+-permeable channels co-exist on lysosomal Ca2+ stores but how each family couples to its own unique downstream physiology is unclear. We have therefore investigated the Ca2+-signalling architecture underpinning different channels
Anthony Morgan, Antony Galione, Lianne C Davis   +2 more
exaly   +2 more sources

Lysosomal TPC2 channel as a new target of chlorpromazine and clomipramine to induce protective autophagy in L-BMAA-induced neurodegeneration [PDF]

Biochemical Pharmacology
Several neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) are characterized by toxic aggregates accumulation due to autophagy blockade, prompting researchers to identify new autophagy-activating drugs.
Preziuso, Alessandra, Pannaccione, Anna, Ruggiero, Giuseppina, Secondo, Agnese, Magliocca, Giorgia, Muraglia, Noemi Di, Esposito, Emilia, Piccirillo, Silvia, Rubino, Valentina, Tedeschi, Valentina, Spadoni, Tatiana, Ciancio, Raffaella   +11 more
exaly   +2 more sources

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TPC1 and TPC2 Promote Osteoclastogenesis

Journal of Hard Tissue Biology, 2021
Yoichi Ezura, Yoshihiro Momota, Tomoe Nakamura   +2 more
exaly  

TPC2 gating: Trying to break the enigma code

Cell Calcium, 2023
Anthony Morgan, Francesco Moccia
exaly  

TPC2 mediates autophagy progression and extracellular vesicle secretion in cancer cells

Experimental Cell Research, 2018
Jianbo Yue
exaly