Results 161 to 170 of about 2,290 (178)

TPD52 represents a survival factor inERBB2‐amplified breast cancer cells

Molecular Carcinogenesis, 2013
AbstractTPD52 and ERBB2 co‐expression has been persistently reported in human breast cancer and animal models of this disease, but the significance of this is unknown. We identified significant positive associations between relativeTPD52andERBB2transcript levels in human diagnostic breast cancer samples, and maximalTPD52expression in the hormone ...
Nuruliza, Roslan, Ivan, Bièche, Robert K, Bright, Rosette, Lidereau, Yuyan, Chen, Jennifer A, Byrne   +5 more
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MiR-125b-5p/TPD52 Axis Affects Proliferation, Migration and Invasion of Breast Cancer Cells

Molecular Biotechnology, 2022
Aberrant gene expression caused by miRNAs disorders plays a relevant role in multiple steps of tumorigenesis. In this attempt, we studied the functional role of miR-125b-5p and TPD52 in breast cancer. TPD52 mRNA and miR-125b-5p levels were assessed via qRT-PCR, and TPD52 protein level was analyzed via western blot.
Yuezhen Wang, Jun Fang, Feiying Gu
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The Role of the Coiled-Coil Motif in Interactions Mediated by TPD52

Biochemical and Biophysical Research Communications, 2001
TPD52 (D52)-like proteins are small coiled-coil motif-bearing proteins first identified through their expression in human breast carcinoma that mutually interact in hetero- and homomeric fashions. However, it has been unclear whether the coiled-coil motif is sufficient, or even necessary, for these interactions to occur.
P, Sathasivam, A M, Bailey, M, Crossley, J A, Byrne   +3 more
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Heightened TPD52 linked to metabolic dysfunction and associated abnormalities in zebrafish

Archives of Biochemistry and Biophysics
The tumor protein D52 (TPD52) gene encodes a proto-oncogene protein associated with various medical conditions, including breast and prostate cancers. It plays a role in multiple biological pathways such as cell growth, differentiation, and apoptosis. The function of TPD52 in lipid droplet biosynthesis has been investigated in vitro.
Hsin-Hung Lai, Kuo-Shyang Jeng, Chung-Tsui Huang, An-Ju Chu, Guor Mour Her   +4 more
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Prognostic role of TPD52 in acute myeloid leukemia: A retrospective multicohort analysis

Journal of Cellular Biochemistry, 2018
AbstractGenerating accurate prognoses is extremely important for treating patients with cancer. Prognostic prediction based on messenger RNA (mRNA) expression has shown superior clinical value to other markers for some cancers but is not currently used for acute myeloid leukemia (AML).
Mihyang Ha, Myoung‐Eun Han, Ji‐Young Kim, Dae Cheon Jeong, Sae‐Ock Oh, Yun Hak Kim   +5 more
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LINC01133 contribute to epithelial ovarian cancer metastasis by regulating miR-495-3p/TPD52 axis

Biochemical and Biophysical Research Communications, 2020
Currently, there is increasing evidence that long noncoding RNAs (lncRNAs) initiate and promote the progression of epithelial ovarian cancer (EOC). In this study, we revealed the roles and the potential mechanisms of long intergenic non-protein coding RNA 1133 (LINC01133) in EOC, which remains not well understood.
Shaoqiu Liu, Xiaowei Xi
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Tumor protein D52 (TPD52) is overexpressed and a gene amplification target in ovarian cancer

International Journal of Cancer, 2005
AbstractRecurrent chromosome 8q gain in ovarian carcinoma is likely to reflect the existence of multiple target loci, as the separate gain of chromosome bands 8q21 and 8q24 has been reported in independent studies. Since tumor protein D52 (TPD52) has been identified as a chromosome 8q21 amplification target in breast and prostate carcinoma, we compared
Jennifer A, Byrne, Rosemary L, Balleine, Marlena, Schoenberg Fejzo, Janelle, Mercieca, Yoke-Eng, Chiew, Yael, Livnat, Luke, St Heaps, Gregory B, Peters, Karen, Byth, Beth Y, Karlan, Dennis J, Slamon, Paul, Harnett, Anna, Defazio   +12 more
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Functional Roles of Tumor Protein D52 (TPD52) in Breast Cancer

Current Cancer Therapy Reviews
: Breast cancer is an aggressive disease with a significant morbidity and death rate among women worldwide. Despite the progress of diagnostic and therapy options for breast cancer in recent years, the prognosis and survival rates of breast cancer patients remain unsatisfactory.
Mojtaba Zehtabi, Mohsen Maleknia, Amir Anbiyaiee, Razieh Mohammad Jafari, Farideh Moramezi, Maryam Farzaneh, Shirin Azizidoost   +6 more
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microRNA-218 inhibits prostate cancer cell growth and promotes apoptosis by repressing TPD52 expression

Biochemical and Biophysical Research Communications, 2015
The tumor protein D52 (TPD52) is an oncogene overexpressed in prostate cancer (PC) due to gene amplification. Although the oncogenic effect of TPD52 is well recognized, how its expression is regulated is still not clear. This study tried to explore the regulative role of miR-218, a tumor suppressing miRNA on TPD52 expression and prostate cancer cell ...
Guangye, Han, Maochuan, Fan, Xinjun, Zhang   +2 more
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TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours

Molecular and Cellular Endocrinology, 2009
Several genomic regions are recurrently over- or underrepresented in testicular germ cell tumours (TGCTs), but only a fraction of their genes change their expression accordingly. Two publications to date have studied DNA copy numbers and associated gene expression changes on a genome-wide level to identify key players in TGCT tumorigenesis.
Sharmini, Alagaratnam, Jayne R, Hardy, Ragnhild A, Lothe, Rolf I, Skotheim, Jennifer A, Byrne   +4 more
openaire   +2 more sources