Results 1 to 10 of about 1,640 (122)

TPD52L2 as a potential prognostic and immunotherapy biomarker in clear cell renal cell carcinoma [PDF]

Frontiers in Oncology, 2023
BackgroundTumor Protein D52-Like 2 (TPD52L2) is a tumor-associated protein that participates in B-cell differentiation. However, the role of TPD52L2 in the pathological process of clear cell renal cell carcinoma (ccRCC) is unclear.MethodsMultiple omics ...
Hongbo Wang, Zhendong Liu, Yuelin Du, Xingbo Cheng, Shanjun Gao, Yanzheng Gao, Panfeng Shang   +6 more
doaj   +7 more sources

TPD52L2 Is a Prognostic Biomarker and Correlated With Immune Infiltration in Lung Adenocarcinoma [PDF]

Frontiers in Pharmacology, 2021
Tumor protein D52-like 2 (TPD52L2) belongs to the members of the TPD52 family. TPD52L2 was reported to regulate proliferation and apoptosis in cancer cells. However, its role in lung adenocarcinoma (LUAD) was uncertain.
Anyuan Zhong, Ting Chen, Tong Zhou, Zengli Zhang, Minhua Shi   +4 more
doaj   +5 more sources

A novel TPD52L2-ROS1 gene fusion expanding the molecular alterations in inflammatory myofibroblastic tumor: case report and literature review [PDF]

Diagnostic Pathology, 2023
Background Inflammatory myofibroblastic tumor (IMT) is a distinctive tumor composed of spindle cells accompanied by mixed inflammatory cells, and immunohistochemical positivity for ALK (anaplastic lymphoma kinase protein) can be detected in half of IMTs.
Xuguang Liu, Yaqi Duan, Guoping Wang, Pengcheng Zhu   +3 more
doaj   +4 more sources

Overexpression of TPD52L2 in HNSCC: prognostic significance and correlation with immune infiltrates [PDF]

BMC Oral Health
Background Evidence has been presented that the tumor protein D52 (TPD52) family plays a critical role in tumor development and progression. As a member of the TPD52 family, the changes in TPD52L2 gene status are instrumental in kinds of cancer ...
Min Lu, Haoyu Xia, Jing Xu, Zijun Liao, Yuwen Li, Hanwei Peng   +5 more
doaj   +4 more sources

Investigation of Transcript Variant 6 of TPD52L2 as a Prognostic and Predictive Biomarker in Basal-Like MDA-MB-231 and MDA-MB-453 Cell Lines for Breast Cancer. [PDF]

Oxid Med Cell Longev, 2022
Background. Basal‐like breast cancer (BLBC) exhibits worse pathological features than other breast cancer subtypes, and patients diagnosed with BLBC have short disease‐free and overall survival times. Thus, the identification of novel biomarkers and therapeutic targets for BLBC is of upmost importance.
Zhang X, O'Brien D, Zhang X.
europepmc   +4 more sources

The Antitumor Effect of TPD52L2 Silencing on Oxaliplatin-Resistant Gastric Carcinoma Is Related to Endoplasmic Reticulum Stress In Vitro. [PDF]

Evid Based Complement Alternat Med, 2022
Tumor protein D52-like 2 or simply TPD52L2 belongs to the TPD52 family which has been implicated in a variety of human carcinomas. However, the TPD52L2 function in the gastric carcinoma oxaliplatin (OXA) resistance remains elusive. The main objective of this study is to evaluate the TPD52L2 effect in OXA-resistant gastric carcinoma cells in vitro ...
Zhang Y, Yang D, Wei Z, Zhang X, Hu Z, Fu H, Xu J, Wang W, Wang W.   +8 more
europepmc   +5 more sources

Mesenchymal stromal cells secretory pattern contributes to oncoinflammatory bone marrow microenvironment in polycythemia vera [PDF]

Hematology, Transfusion and Cell Therapy
Introduction: Polycythemia vera is a myeloproliferative neoplasm marked by an increased proliferation of erythroid mature and precursors cells in bone marrow and peripheral blood. The pathophysiology is linked to the presence of the JAK2 driver mutation,
Juçara Gastaldi Cominal, Maira da Costa Cacemiro, Giovana Michelassi Berbel, Rifkath Marie Laurance Rahimy, Gisele Vieira Rocha, Dalila Lucíola Zanette, Maria Carolina Oliveira, Lorena Lobo de Figueiredo-Pontes, Kelen Cristina Ribeiro Malmegrim, Fabíola Attié de Castro   +9 more
doaj   +2 more sources

Genomic analysis reveals convergent signatures of selection for milk traits in sheep and goats [PDF]

Journal of Animal Science and Biotechnology
Background Convergent evolution offers a unique lens through which to explore the molecular underpinnings of significant phenotypic transformations.
Zhanerke Akhatayeva, Yilong Shi, Kairat Dossybayev, Nurlan Malmakov, Hairong Cheng, Narantuya Baatar, Ji Yang, Menghua Li, Kejian Lin, Songsong Xu   +9 more
doaj   +2 more sources

Dual oncogenic roles of TPD52 and TPD52L2 in gastric cancer progression via PI3K/AKT activation and immunosuppressive microenvironment remodeling. [PDF]

Brief Funct Genomics
Abstract Aim TPD52 (tumor protein D52) and TPD52L2 (tumor protein D52-like 2), members of the TPD52 gene family, have been implicated in multiple malignancies. However, their roles in gastric cancer (GC) remain elusive. Herein, we integrated multiomics analyses and experimental validation to elucidate
Li H, Gao X, Guo S, Gao S, Yang C, Su R, Jing Z, Qiu S, Tang P, Han J.   +9 more
europepmc   +3 more sources

TPD52L2 impacts proliferation, invasiveness and apoptosis of glioblastoma cells via modulation of wnt/β-catenin/snail signaling [PDF]

Carcinogenesis, 2017
Intratumoral heterogeneity greatly hinders efficiency of target therapy in glioblastoma (GBM). To decipher the underlying mechanisms of heterogeneity, patient-derived adult GBM cells were separately isolated from margins of T1 gadolinium enhancing tumor lesions (PNCs) and T1 gadolinium enhancing core lesions (ECs). Single clone culture was conducted in
Zhou, Qiang, Li, Jun-Jie, Wang, Hai, Li, Hong, Lei, Bing-Xi, Chen, Lei, Xiang, Wei, Liu, Ya-Wei, Annie, Huang, Qi, Song-Tao, Lu, Yun-Tao   +10 more
openaire   +2 more sources