TPD52L2 as a potential prognostic and immunotherapy biomarker in clear cell renal cell carcinoma [PDF]
Frontiers in Oncology, 2023 BackgroundTumor Protein D52-Like 2 (TPD52L2) is a tumor-associated protein that participates in B-cell differentiation. However, the role of TPD52L2 in the pathological process of clear cell renal cell carcinoma (ccRCC) is unclear.MethodsMultiple omics ...
Hongbo Wang +6 more
doaj +5 more sources
A novel TPD52L2-ROS1 gene fusion expanding the molecular alterations in inflammatory myofibroblastic tumor: case report and literature review [PDF]
Diagnostic Pathology, 2023 Background Inflammatory myofibroblastic tumor (IMT) is a distinctive tumor composed of spindle cells accompanied by mixed inflammatory cells, and immunohistochemical positivity for ALK (anaplastic lymphoma kinase protein) can be detected in half of IMTs.
Xuguang Liu +3 more
doaj +2 more sources
TPD52L2 Is a Prognostic Biomarker and Correlated With Immune Infiltration in Lung Adenocarcinoma [PDF]
Frontiers in Pharmacology, 2021 Tumor protein D52-like 2 (TPD52L2) belongs to the members of the TPD52 family. TPD52L2 was reported to regulate proliferation and apoptosis in cancer cells. However, its role in lung adenocarcinoma (LUAD) was uncertain.
Anyuan Zhong +4 more
doaj +2 more sources
Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays [PDF]
BMC Genomics, 2008 Background Tumor-predominant splice isoforms were identified during comparative in silico sequence analysis of EST clones, suggesting that global aberrant alternative pre-mRNA splicing may be an epigenetic phenomenon in cancer. We used an exon expression
Nixon Tamara J +8 more
doaj +5 more sources
Overexpression of TPD52L2 in HNSCC: prognostic significance and correlation with immune infiltrates [PDF]
BMC Oral HealthBackground Evidence has been presented that the tumor protein D52 (TPD52) family plays a critical role in tumor development and progression. As a member of the TPD52 family, the changes in TPD52L2 gene status are instrumental in kinds of cancer ...
Min Lu +5 more
doaj +2 more sources
Mesenchymal stromal cells secretory pattern contributes to oncoinflammatory bone marrow microenvironment in polycythemia vera [PDF]
Hematology, Transfusion and Cell TherapyIntroduction: Polycythemia vera is a myeloproliferative neoplasm marked by an increased proliferation of erythroid mature and precursors cells in bone marrow and peripheral blood. The pathophysiology is linked to the presence of the JAK2 driver mutation,
Juçara Gastaldi Cominal +9 more
doaj +2 more sources
Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases [PDF]
, 2017 We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting ...
A Cepeda-Benito +59 more
core +14 more sources
The human RBPome: From genes and proteins to human disease [PDF]
, 2015 RNA binding proteins (RBPs) play a central role in mediating post transcriptional regulation of genes. However less is understood about them and their regulatory mechanisms.
Hashemikhabir, Seyedsasan +2 more
core +1 more source
Cis and Trans Effects of Human Genomic Variants on Gene Expression [PDF]
, 2014 This work was funded by the Louis-Jeantet Foundation (http://www.jeantet.ch/), the European Research Council (Grant ID: 260927 http://erc.europa.eu/), the Swiss National Foundation (Grant ID: 130342 http://www.snf.ch), NCCR Frontiers In Genetics (http ...
A Boyd +53 more
core +5 more sources
Tumor protein D54 defines a new class of intracellular transport vesicles [PDF]
, 2019 Transport of proteins and lipids from one membrane compartment to another is via intracellular vesicles. We investigated the function of tumor protein D54 (TPD54/TPD52L2) and found that TPD54 was involved in multiple membrane trafficking pathways ...
Balch +63 more
core +1 more source