Results 11 to 20 of about 1,612 (113)

Investigation of Transcript Variant 6 of TPD52L2 as a Prognostic and Predictive Biomarker in Basal-Like MDA-MB-231 and MDA-MB-453 Cell Lines for Breast Cancer. [PDF]

Oxid Med Cell Longev, 2022
Background. Basal‐like breast cancer (BLBC) exhibits worse pathological features than other breast cancer subtypes, and patients diagnosed with BLBC have short disease‐free and overall survival times. Thus, the identification of novel biomarkers and therapeutic targets for BLBC is of upmost importance.
Zhang X, O'Brien D, Zhang X.
europepmc   +2 more sources

The Antitumor Effect of TPD52L2 Silencing on Oxaliplatin-Resistant Gastric Carcinoma Is Related to Endoplasmic Reticulum Stress In Vitro. [PDF]

Evid Based Complement Alternat Med, 2022
Tumor protein D52‐like 2 or simply TPD52L2 belongs to the TPD52 family which has been implicated in a variety of human carcinomas. However, the TPD52L2 function in the gastric carcinoma oxaliplatin (OXA) resistance remains elusive. The main objective of this study is to evaluate the TPD52L2 effect in OXA‐resistant gastric carcinoma cells in vitro ...
Zhang Y, Yang D, Wei Z, Zhang X, Hu Z, Fu H, Xu J, Wang W, Wang W.   +8 more
europepmc   +2 more sources

Identification of Key MicroRNAs and Genes between Colorectal Adenoma and Colorectal Cancer via Deep Learning on GEO Databases and Bioinformatics.

Contrast Media Mol Imaging, 2023
Background. Deep learning techniques are gaining momentum in medical research. Colorectal adenoma (CRA) is a precancerous lesion that may develop into colorectal cancer (CRC) and its etiology and pathogenesis are unclear. This study aims to identify transcriptome differences between CRA and CRC via deep learning on Gene Expression Omnibus (GEO ...
Zhang X, Jin M, Liu F, Qu H, Chen C.
europepmc   +2 more sources

GRB2 Promotes Malignant Behaviors of Breast Cancer by Modulating the Global Expression and Alternative Splicing Profiles in SK-BR-3 Cells Through Binding mRNA. [PDF]

Cancer Med
GRB2 as a flexible protein and an RBP that is involved in post‐transcriptional regulation in eukaryotes, influencing all stages of mRNA synthesis, modification, splicing, and stabilization. ABSTRACT Purpose The flexible protein GRB2 interacts with HER1–4 on the cell surface and regulates the development of tumor cells; meanwhile, it is also an RBP that
Liu W, Huang Y, Qiao L, Chong L, Xia L, Abudurehaman A, Li H.   +6 more
europepmc   +2 more sources

Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia

Journal of Extracellular Vesicles, Volume 12, Issue 12, December 2023., 2023
Abstract Periodontitis is a chronic inflammatory disease caused by periodontal pathogens in subgingival plaque and is associated with systemic inflammatory diseases. Extracellular vesicles (EVs) released from host cells and pathogens carry a variety of biological molecules and are of interest for their role in disease progression and as diagnostic ...
Younggap Lim, Hyun Young Kim, Dohyun Han, Bong‐Kyu Choi   +3 more
wiley   +1 more source

Identification of diagnostic markers of pancreatic ductal adenocarcinoma using transcriptomic tumour and blood sample data

Clinical and Translational Discovery, Volume 3, Issue 5, October 2023., 2023
In this study, we pool publicly available gene expression data from clinical samples (tissue biopsies and blood samples) and derive and validate a signature of consistently deregulated genes across pancreatic ductal adenocarcinoma (PDAC) samples.
Aristeidis Sionakidis, Panagiotis Nikolaos Lalagkas, Andigoni Malousi, Ioannis S. Vizirianakis   +3 more
wiley   +1 more source

Human amygdala involvement in Alzheimer's disease revealed by stereological and dia‐PASEF analysis

Brain Pathology, Volume 33, Issue 5, September 2023., 2023
A combined stereological and proteomic analysis revealed amygdala volume reduction linked to synaptic dysfunction in Alzheimer''s disease samples. The pathological markers gradient suggested the relevance of connections in the distribution of the pathology among different brain regions.
Melania Gonzalez‐Rodriguez, Sandra Villar‐Conde, Veronica Astillero‐Lopez, Patricia Villanueva‐Anguita, Isabel Ubeda‐Banon, Alicia Flores‐Cuadrado, Alino Martinez‐Marcos, Daniel Saiz‐Sanchez   +7 more
wiley   +1 more source

Clathrin light chain A‐enriched small extracellular vesicles remodel microvascular niche to induce hepatocellular carcinoma metastasis

Journal of Extracellular Vesicles, Volume 12, Issue 8, August 2023., 2023
Abstract Small extracellular vesicles (sEVs) play a key role in exchanging cargoes between cells in tumour microenvironment. This study aimed to elucidate the functions and mechanisms of hepatocellular carcinoma (HCC) derived sEV‐clathrin light chain A (CLTA) in remodelling microvascular niche.
Yi Xu, Yue Yao, Liang Yu, Xiaoxin Zhang, Xiaowen Mao, Sze Keong Tey, Samuel Wan Ki Wong, Cherlie Lot Sum Yeung, Tung Him Ng, Melody YM Wong, Chi‐Ming Che, Terence Kin Wah Lee, Yi Gao, Yunfu Cui, Judy Wai Ping Yam   +14 more
wiley   +1 more source

Tumor protein D52 (TPD52) affects cancer cell metabolism by negatively regulating AMPK

Cancer Medicine, Volume 12, Issue 1, Page 488-499, January 2023., 2023
TPD52 forms a stable complex with AMPKα and negatively regulates AMPKα kinase activity. TPD52 modulates cell metabolism through regulating AMPK. Abstract Background The AMP‐activated protein kinase (AMPK) is a central regulator of energy homeostasis, with deregulation leading to cancer and other diseases.
Yali Chen, Changmin Peng, Wei Tan, Jia Yu, Jacqueline Zayas, Yihan Peng, Zhenkun Lou, Huadong Pei, Liewei Wang   +8 more
wiley   +1 more source

Interacting partners of Golgi‐localized small G protein Arl5b identified by a combination of in vivo proximity labelling and GFP‐Trap pull down

FEBS Letters, Volume 596, Issue 18, Page 2382-2399, September 2022., 2022
Identifying interactomes of membrane‐associated small G proteins is challenging. Here, we applied three proteomic approaches to identify the interactive neighbourhood of constitutively active Arl5b, a small G protein of the trans‐Golgi network (TGN). 50% of the hits were TGN/Golgi‐localised small G proteins, indicating an organised complex of small G ...
Fiona J. Houghton, Christian Makhoul, Ellie Hyun‐Jung Cho, Nicholas A. Williamson, Paul A. Gleeson   +4 more
wiley   +1 more source