Results 31 to 40 of about 1,612 (113)

GCN2:roles in tumour development and progression [PDF]

, 2022
GCN2 (general control nonderepessible 2) is an eIF2α kinase responsible for entirely rewiring the metabolism of cells when they are put under amino acid starvation stress.
Gold, Lyssa T., Masson, Glenn
core   +2 more sources

Multiple tests of association with biological annotation metadata

, 2008
We propose a general and formal statistical framework for multiple tests of association between known fixed features of a genome and unknown parameters of the distribution of variable features of this genome in a population of interest.
Mark J. Van Der Laan, Mark J. Van Der Laan, Rine Dudoit, Rine Dudoit Sunduz Keles, Sunduz Keles   +4 more
core   +2 more sources

A functional variant on 20q13.33 related to glioma risk alters enhancer activity and modulates expression of multiple genes. [PDF]

, 2021
Genome-wide association studies (GWAS) have identified single-nucleotide polymorphisms (SNPs) associated with glioma risk on 20q13.33, but the biological mechanisms underlying this association are unknown.
Adli, Mazhar, Ali, Mourad Wagdy, Casey, Graham, Dampier, Christopher H, Kuscu, Cem, Lai, Rose K, Lau, Ching C, Patro, C Pawan K, Plummer, Sarah J, Zhu, Jacqueline Jufen   +9 more
core   +1 more source

Transcriptomes reflect the phenotypes of undifferentiated, granulocyte and macrophage forms of HL-60/S4 cells [PDF]

, 2017
Author Posting. © The Author(s), 2017. This is the author's version of the work. It is posted here by permission of Taylor & Francis for personal use, not for redistribution.
Jauch, Anna, Langowski, Jörg, Mark Welch, David B., Olins, Ada L., Olins, Donald E.   +4 more
core   +2 more sources

Tracing recombinant bovine somatotropin ab(use) through transcriptomics: the potential of bovine somatic cells in a multi-dose longitudinal study [PDF]

, 2019
In the European Union, the use of recombinant bovine somatotropin (rbST) in dairy cattle is forbidden. Monitoring rbST (ab)use by its direct detection in animal matrices still remains a challenging task. New monitoring methods based on indirect detection
Cepeda Sáez, Alberto, Franco Abuín, Carlos Manuel, Lamas Freire, Alexandre, Miranda López, José Manuel, Regal López, Patricia, Vázquez Belda, Beatriz Isabel   +5 more
core   +2 more sources

New insights into the mechanisms of childhood food allergies

Pediatric Allergy and Immunology, Volume 36, Issue 4, April 2025.
Abstract IgE‐mediated food allergies are common and can be life‐threatening, especially for children. With increasingly rapid advances in immunological technologies, including the ability to profile highly complex immune features from small sample volumes, our understanding of the immune mechanisms that underpin the development of food allergies ...
Liam Gubbels, Richard Saffery, Melanie R. Neeland   +2 more
wiley   +1 more source

Quantitative SWATH-based proteomic profiling of urine for the identification of endometrial cancer biomarkers in symptomatic women [PDF]

, 2023
BackgroundA non-invasive endometrial cancer detection tool that can accurately triage symptomatic women for definitive testing would improve patient care.
Agnew, Heather, Armit, Alexander, Baricevic-Jones, Ivona, Campbell, Amy E., Chiasserini, Davide, Crosbie, Emma J., Da Sylva, Rachel, Geary, Bethany, Kelsall, Janet, Njoku, Kelechi, Pierce, Andrew, Reed, Rachel, Whetton, Anthony D., Zhang, Liqun   +13 more
core   +2 more sources

Time‐Lapse Acquisition of Both Freely Secreted Proteome and Exosome Encapsulated Proteome in Live Organoids’ Microenvironment

Advanced Science, Volume 12, Issue 2, January 13, 2025.
Proteomic communications in neighboring microenvironments during early organ development is a dynamic process continuously reshaping hESCs developmental fate. Such dynamic proteomic alteration consists of freely secreted proteome and exosome‐encapsulated proteome.
Haoni Yan, Aynur Abdulla, Aiting Wang, Shuyu Ding, Manlin Zhang, Yizhi Zhang, Tsz Yui Zhuang, Leqi Wu, Yan Wang, Rongrong Ren, Lai Jiang, Xianting Ding   +11 more
wiley   +1 more source

The selenoenzyme type I iodothyronine deiodinase: a new tumor suppressor in ovarian cancer

Molecular Oncology, Volume 18, Issue 9, Page 2298-2313, September 2024.
The selenoenzyme deiodinase type 1 (DIO1) has anti‐tumor actions in high‐grade serous ovarian cancer. Reduced levels of DIO1 in HGSOC cells and human tissues facilitate proliferation and may promote tumorigenesis in this aggressive disease. The selenoenzyme type I iodothyronine deiodinase (DIO1) catalyzes removal of iodine atoms from thyroid hormones ...
Adi Alfandari, Dotan Moskovich, Avivit Weisz, Aviva Katzav, Debora Kidron, Mario Beiner, Dana Josephy, Aula Asali, Yael Hants, Yael Yagur, Omer Weitzner, Martin Ellis, Gilad Itchaki, Osnat Ashur‐Fabian   +13 more
wiley   +1 more source

Optimization of ultracentrifugation‐based method to enhance the purity and proteomic profiling depth of plasma‐derived extracellular vesicles and particles

Journal of Extracellular Biology, Volume 3, Issue 7, July 2024.
Abstract Circulating extracellular vesicles and particles (EVPs) are being investigated as potential biomarkers for early cancer detection, prognosis, and disease monitoring. However, the suboptimal purity of EVPs isolated from peripheral blood plasma has posed a challenge of in‐depth analysis of the EVP proteome. Here, we compared the effectiveness of
Zurong Wan, Jinghua Gu, Uthra Balaji, Linda Bojmar, Henrik Molina, Søren Heissel, Alexandra E. Pagano, Christopher Peralta, Lee Shaashua, Dorina Ismailgeci, Hope K. Narozniak, Yi Song, William R. Jarnagin, David P. Kelsen, Jaqueline Bromberg, Virginia Pascual, Haiying Zhang   +16 more
wiley   +1 more source