Results 91 to 100 of about 8,275 (209)

The Identification of a Novel Thiopurine S-Methyltransferase Allele, TPMT*45, in Korean Patient with Crohn’s Disease

open access: yesPharmacogenomics and Personalized Medicine, 2020
Changhee Ha,1 Eun Sil Kim,2 Yiyoung Kwon,2 Yon Ho Choe,2 Mi Jin Kim,2 Soo-Youn Lee1,3 1Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 2Department of Pediatrics, Samsung ...
Ha C   +5 more
doaj  

The derivation of a long term milk supply model from an optimization model [PDF]

open access: yes
Models;Investment Planning;Dairy Farm;agricultural ...
Roemen, J.H.J.
core   +1 more source

Coherent phonon dynamics at the martensitic phase transition of Ni_2MnGa

open access: yes, 2012
We use time-resolved optical reflectivity to study the laser stimulated dynamics in the magnetic shape memory alloy Ni_2MnGa. We observe two coherent optical phonons, at 1.2 THz in the martensite phase and at 0.7 THz in the pre-martensite phase, which we
Beaud, P.   +4 more
core   +1 more source

Thiopurine S-Methyltransferase Assay by HPLC in Acute Lymphoblastic Leukemia Patients and a Healthy Iranian Population

open access: yesActa Medica Iranica, 2018
Thiopurine s-methyltransferase (TPMT) plays a key role in the metabolism of the drug; 6-MP in children with acute lymphoblastic leukemia (ALL). The wild-type TPMT*1 allele and mutant alleles are associated with normal and intermediate enzyme activity ...
Sima Mozafari   +4 more
doaj  

A Practical Non-Extraction Direct Liquid Chromatography Method for Determination of Thiopurine S-Methyltransferase Activity in Inflammatory Bowel Disease

open access: yesActa Medica Iranica, 2017
Thiopurine drugs remain pivotal therapies for the wide varieties of diseases such as inflammatory bowel disease (IBD). Here, thiopurine S-methyltransferase (TPMT) phenotype, the main metabolizing enzyme of thiopurine-drugs, was studied.
Fariborz Bahrehmand   +6 more
doaj  

Severe Myelotoxicity Associated with Thiopurine S-Methyltransferase*3A/*3C Polymorphisms in a Patient with Pediatric Leukemia and the Effect of Steroid Therapy

open access: yesTurkish Journal of Hematology, 2014
Myelosuppression is a serious complication during treatment of acute lymphoblastic leukemia and the duration of myelosuppression is affected by underlying bone marrow failure syndromes and drug pharmacogenetics caused by genetic polymorphisms.
Burcu Fatma Belen   +5 more
doaj   +1 more source

Thiopurine S-methyltransferase activity in Nigerians: phenotypes and activity reference values

open access: yesBMC Research Notes, 2018
Objectives This study assessed the activity of thiopurine S-methyltransferase (TPMT) in Nigerians with a view to providing data on susceptibility to thiopurine toxicity, and as well generate reference activity values for clinical use.
Ayorinde Adehin, Oluseye O. Bolaji
doaj   +1 more source

Personalised medicine, unmet need or business strategy?

open access: yes, 2013
Personalised medicine is a discipline that integrates pharmaceutical development with existing knowledge about the genetic and phenotypic factors that influence drug response.
Sáinz de la Fuente, G. (Graciela)
core  

Transmission Lags and Optimal Monetary Policy [PDF]

open access: yes, 2012
Real world monetary policy is complicated by long and variable lags in the transmission of the policy to the economy. Most of the policy models, however, abstracts from policy lags.
Flamini, Alessandro
core  

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