Results 101 to 110 of about 8,275 (209)
Thiopurines Induce Oxidative Stress in T-Lymphocytes: A Proteomic Approach
Mediators of Inflammation, 2015 Thiopurines are extensively used immunosuppressants for the treatment of inflammatory bowel disease (IBD). The polymorphism of thiopurine S-methyltransferase (TPMT) influences thiopurine metabolism and therapy outcome. We used a TPMT knockdown (kd) model
Misbah Misdaq +4 more
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Genetic Polymorphism of Thiopurine S-Methyltransferase in Children with Acute Lymphoblastic Leukemia
Pakistan Journal of Medicine and DentistryBackground: 6-Mercaptopurine (6-MP), a widely used anti-metabolite for the maintenance phase of childhood acute lymphoblastic leukemia (ALL), has been observed to cause myelotoxicity due to genetic polymorphism of thiopurine methyl transferase (TPMT ...
Afrina Raza +3 more
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Thiopurine S-methyl Transferase (TPMT) Enzyme Level in Healthy Sudanese Population
Sudan Journal of Medical SciencesBackground: Thiopurine drugs have limited use due to their toxicity, related to the enzyme thiopurine S-methyl transferase (TPMT) activity, which varies between individuals.
Rayan Khalid +3 more
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中枢神经系统脱髓鞘疾病患者TPMT基因突变与硫唑嘌呤所致毒副反应的关系
Zhongshan Daxue xuebao. Yixue kexue ban, 2016 摘 要: 【目的】 探讨中枢神经系统脱髓鞘疾病患者巯代嘌呤甲基转移酶(TPMT)基因突变与硫唑嘌呤(AZA)所致的毒副反应之间的关系?【方法】 选择自2012年至2014年在中山大学附属第三医院就诊的224例患者(包括135例中枢神经系统脱髓鞘疾病患者和89例非中枢神经系统脱髓鞘疾病患者)进行前瞻性研究:给予中枢神经系统脱髓鞘疾病患者AZA口服(25 ~ 100 mg/d),观察2个月后出现的毒副反应情况;同时采用PCR-SNaPshot方法检测224例患者4种常见的TPMT突变等位基因TPMT *2 ...
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