MiX: A Position Sensitive Dual-Phase Liquid Xenon Detector
, 2015 The need for precise characterization of dual-phase xenon detectors has grown as the technology has matured into a state of high efficacy for rare event searches.
Haefner, J. +10 more
core +1 more source
Acta Clinica Croatica, 2016 Thiopurine S-methyltransferase (TPMT) is an enzyme that converts thiopurine drugs into inactive metabolites. Over 20 variant TPMT-encoding alleles, which cause reduced enzymatic activity, have been discovered so far.
Agata Ladić +5 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt +13 more
wiley +1 more source
Frequency of thiopurine S-methyltransferase gene variations in Turkish children with acute leukemia
The Turkish Journal of Pediatrics, 2018 In this study we aim to determine the genotype distribution and allele frequencies of common TPMT (*2, *3A, *3B and *3C) polymorphisms in Turkish children with acute leukemia.
Dilara Fatma Akın +3 more
doaj +1 more source
A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALL [PDF]
Leukemia, 2003 A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ...
E Schaeffeler +6 more
openaire +1 more source
Thiopurine S -methyltransferase polymorphisms: efficient screening method for patients considering taking thiopurine drugs [PDF]
, 2018 Objective: More than 11% of the Caucasian population are heterozygous or homozygous carriers of thiopurine S-methyltransferase (TPMT) mutants and are at risk for toxic side effects when treated with thiopurine drugs.
Fried, M. +5 more
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Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial [PDF]
, 2016 Carboplatin/taxane combination is first-line therapy for ovarian cancer. However, patients can encounter treatment delays, impaired quality of life, even death because of chemotherapy-induced gastrointestinal (GI) toxicity.
Brown, R. +7 more
core +1 more source
Direct evidence of singlet molecular oxygen [O2 (1Δg)] production from UVA excited 6‐thioguanine
Photochemistry and Photobiology, EarlyView.6‐Thioguanine (6‐TGua) is incorporated into DNA as a purine analogue, inhibiting cell replication. Patients treated with 6‐TGua are more prone to developing skin cancer due to the photoexcitation of 6‐TGua by UVA radiation (as illustrated in the Jablonski diagram). Upon exposure to UVA, the excited 6‐TGua generates 1O2.
André L. Lopes +6 more
wiley +1 more source
Enhanced proteolysis of thiopurine S -methyltransferase (TPMT) encoded by mutant alleles in humans ( TPMT ∗ 3 A , TPMT ∗ 2 ): Mechanisms for the genetic polymorphism of TPMT activity [PDF]
Proceedings of the National Academy of Sciences, 1997 TPMT is a cytosolic enzyme that catalyzes the S -methylation of aromatic and heterocyclic sulfhydryl compounds, including medications such as mercaptopurine and thioguanine. TPMT activity exhibits autosomal codominant genetic polymorphism, and patients inheriting TPMT deficiency are at high risk of potentially fatal
Hung-Liang Tai +4 more
openaire +1 more source
Azathioprine-Induced Peripheral T Cell Apoptosis And Drug Response In Patients With Crohn’s Disease [PDF]
, 2011 Background and Aim: the long time interval for a trial of thioupurine therapy and the potential side effects in spite of the proven efficacy, do not encourage their use as early therapeutic option in Crohn’s Disease (CD).
Cossu, Andrea
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