Results 51 to 60 of about 8,275 (209)

Trigger point manual therapy for the treatment of chronic non-cancer pain in adults [PDF]

, 2015
This is the protocol for a review and there is no abstract. The objectives are as follows: To determine the effectiveness of trigger point manual therapy for treating chronic non-cancer pain in ...
Brook, S, Denneny, D, Hassan, S, McLoughlin, R, Petersen, K, Williams, ACDEC   +5 more
core   +1 more source

Model‐Based Strategy for 6‐Mercaptopurine Treatment in Acute Lymphoblastic Leukemia Maintenance Phase: Prediction of 6‐TGN and 6‐MMP Concentrations to Optimize Treatment

Pediatric Blood &Cancer, Volume 73, Issue 4, April 2026.
ABSTRACT Introduction Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. The pro‐drug 6‐mercaptopurine (6‐MP), essential during maintenance, is converted into active 6‐thioguanine (6‐TGN) and toxic 6‐methylmercaptopurine (6‐MMP) metabolites, resulting in marked variability in efficacy and toxicity.
Anne Ravix, Anaïs Maillat, Eva Choong, Chantal Csajka, Monia Guidi, Francesco Ceppi   +5 more
wiley   +1 more source

بررسی شيوع آلل‌های شناخته‌شده ژن آنزيم تيوپورين متيل تراسفراز (TPMT) در مراجعه کنندگان به درمانگاه بيمارستان شريعتی تهران [PDF]

, 2009
زمينه: بيماران با سطوح پائين و يا متوسط فعاليت آنزيم تيوپورين متيل تراسفراز (TPMT) در معرض افزايش خطر ابتلا به سرکوب سلول‎های رده خون ساز مغز استخوان پس از مصرف داروهای تيويورينی خواهند بود.
آزادی, مهدی, حاجی فتحعلی, عباس, سلیمانی, مسعود, نوروزی نیا, مهرداد, کاویانی, سعید   +4 more
core  

Traditional Chinese medicine combination therapy for patients with steroid-dependent ulcerative colitis: study protocol for a randomized controlled trial [PDF]

, 2017
SPIRIT 2013 Checklist: recommended items to address in a clinical trial protocol and related documents.
Hong Shen, Jia Jia, Kai Zheng, Lei Zhu, Lu Zhang, Yuelin Lu, Zhaofeng Shen   +6 more
core   +3 more sources

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 953-963, April 2026.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

Polimorfismos del gen tiopurina S-metiltransferasa (TPMT) en pacientes pediátricos peruanos con leucemia linfoblástica aguda

Horizonte Médico
Objetivo: Identificar las frecuencias alélicas, genotípicas y los fenotipos probables de las variantes del gen tiopurina S-metiltransferasa (TPMT) en una cohorte de pacientes pediátricos con leucemia linfoblástica aguda (LLA) tipo B, atendidos en el ...
Kelly Franco-Bustamante, Julio A. Poterico, Francisco Sánchez-Pinto, Joselyne Talledo-Rodríguez, María C. Medina-Pflucker, Victoria Godoy-Vila, Gioconda Manassero-Morales   +6 more
doaj   +1 more source

Common Polymorphism’s Analysis of Thiopurine S-Methyltransferase (TPMT) in Iranian Population [PDF]

Cell Journal, 2009
Objective: Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurinedrugs. Low activity phenotypes are correlated with several mutations in the TPMTgene and adverse drug reactions.
Mehdi Azad, Saeid Kaviani, Masoud Soleimani, Mehrdad Noruzinia, Abbas Hajfathali   +4 more
doaj  

Examining perceptions of the usefulness and usability of a mobile-based system for pharmacogenomics clinical decision support: A mixed methods study [PDF]

, 2016
Background. Pharmacogenomic testing has the potential to improve the safety and efficacy of pharmacotherapy, but clinical application of pharmacogenetic knowledge has remained uncommon.
Blagec, K, Boyce, RD, Romagnoli, KM, Samwald, M   +3 more
core   +4 more sources

Supervised learning of protein variant effects across large‐scale mutagenesis datasets

Protein Science, Volume 35, Issue 4, April 2026.
Abstract The increasing availability of data from multiplexed assays of variant effects (MAVEs) enables supervised model training against large quantities of experimental data to learn sequence‐function relationships. Variant effect scores from MAVEs can, however, be influenced by the experimental method and library composition, resulting in experiment‐
Thea K. Schulze, Lasse M. Blaabjerg, Matteo Cagiada, Kresten Lindorff‐Larsen   +3 more
wiley   +1 more source

A bioinformatics approach to the identification of novel deleterious mutations of human TPMT through validated screening and molecular dynamics

Scientific Reports, 2022
Polymorphisms of Thiopurine S-methyltransferase (TPMT) are known to be associated with leukemia, inflammatory bowel diseases, and more. The objective of the present study was to identify novel deleterious missense SNPs of TPMT through a comprehensive in ...
Sidharth Saxena, T. P. Krishna Murthy, C. R. Chandrashekhar, Lavan S. Patil, Abhinav Aditya, Rohit Shukla, Arvind Kumar Yadav, Tiratha Raj Singh, Mahesh Samantaray, Amutha Ramaswamy   +9 more
doaj   +1 more source