Results 71 to 80 of about 8,275 (209)

Challenges in implementing individualized medicine illustrated by antimetabolite therapy of childhood acute lymphoblastic leukemia [PDF]

, 2011
Predicting the response to medical therapy and subsequently individualizing the treatment to increase efficacy or reduce toxicity has been a longstanding clinical goal.
Jacob Nersting, Louise Borst, Kjeld Schmiegelow   +2 more
core   +2 more sources

The Association Between Azathioprine Genetic Polymorphisms, Clinical Efficacy and Adverse Drug Reactions Among Egyptian Patients with Autoimmune Diseases

Pharmacogenomics and Personalized Medicine, 2021
Nermeen Abuelsoud,1,2 Hala Fayed,3 Engy Elkateeb4 1Department of Clinical Pharmacy Practice, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt; 2Department of Pharmacy Practice/Clinical Pharmacy, Faculty of Pharmacy, Egyptian Russian ...
Abuelsoud N, Fayed H, Elkateeb E
doaj  

TPMT status determination: The simplest is the most effective? [PDF]

Journal of Crohn's and Colitis, 2012
Dear Sir, We carefully read the article by Hindorf and Appell stating that genotyping should be considered the primary choice for pre-treatment evaluation of thiopurine methyltransferase (TPMT) function.1 As evidence since many years, TPMT status should be determined before a thiopurine treatment to identify patients at risk for severe adverse events,
Laurent, Chouchana, Celine, Narjoz, Marie-Anne, Loriot   +2 more
openaire   +2 more sources

Insights Into Patient‐Level Exposure to Actionable Pharmacogenomic Medications in Australia Using a New National Pharmacogenomic Guideline

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 89-100, January 2026.
This study assessed the use of 35 pharmacogenomic (PGx) medications listed in the Royal College of Pathologists of Australasia (RCPA) guideline, estimated the potential costs of subsidizing PGx testing in Australia, and predicted related prescribing changes.
Bella D. Ianni, Chin Hang Yiu, Mohammad A. Ali, Christine Y. Lu   +3 more
wiley   +1 more source

Personalization of thiopurine therapy: Current recommendations and future perspectives

Acta Pharmaceutica
Despite great therapeutic advances in the field of biologics, small synthetic molecules such as thiopurines, including azathioprine, mercaptopurine, and thioguanine, remain an important therapeutic pillar in the treatment of inflammatory bowel disease ...
Urbančič Dunja, Pasha Flaka, Šmid Alenka, Mlinarič-Raščan Irena   +3 more
doaj   +1 more source

The Role of Time Preferences in the Intergenerational Transfer of Smoking [PDF]

, 2013
Peer reviewedPublisher ...
Brown, Heather, van der Pol, Marjon
core   +1 more source

Variants in TPMT, ITPA, ABCC4 and ABCB1 genes as predictors of 6-mercaptopurine induced toxicity in children with acute lymphoblastic leukemia [PDF]

Journal of Medical Biochemistry, 2018
Background: Acute lymphoblastic leukemia is the most common childhood malignancy. Optimal use of anti leukemic drugs has led to less toxicity and adverse reactions, and a higher survival rate. Thiopurine drugs, including 6-mercaptopurine, are mostly used
Milošević Goran, Kotur Nikola, Krstovski Nada, Lazić Jelena, Zukić Branka, Stanković Biljana, Janić Dragana, Katsila Theodora, Patrinos George P., Pavlović Sonja, Dokmanović Lidija   +10 more
doaj  

Thiopurine Methyltransferase Enzyme Activity Determination before Treatment of Inflammatory Bowel Disease with Azathioprine: Effect on Cost and Adverse Events

Canadian Journal of Gastroenterology, 2005
BACKGROUND: Azathioprine (AZA), used to treat inflammatory bowel disease (IBD), is metabolized by thiopurine methyltransferase (TPMT). The accumulation of individual metabolites varies because humans display genetic polymorphism for TPMT expression ...
Farzana A Sayani, Connie Prosser, Robert J Bailey, Philip Jacobs, Richard N Fedorak   +4 more
doaj   +1 more source

Imputation of TPMT defective alleles for the identification of patients with high-risk phenotypes

Frontiers in Genetics, 2014
Background: The activity of thiopurine methyltransferase (TPMT) is subject to genetic variation. Loss-of-function alleles are associated with various degrees of myelosuppression after treatment with thiopurine drugs, thus genotype-based dosing ...
Berta eAlmoguera, Lyam eVazquez, John J Connolly, Jonathan eBradfield, Patrick eSleiman, Patrick eSleiman, Brendan eKeating, Hakon eHakonarson, Hakon eHakonarson   +8 more
doaj   +1 more source

Clinical Implementation of Pharmacogenomics and Drug–Drug Interaction Screening in a German Academic Teaching Hospital and Outpatient Follow‐Up

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 241-254, January 2026.
Overview of the implemented pharmacogenomics (PGx) process in clinical routine at the Robert Bosch Hospital: from patient enrollment via the hospital information system, DNA detection using a customized TaqMan OpenArray panel and qPCR for CNV assessment, to clinical translation of genotyping results into PGx guideline‐based recommendations using a ...
Roman Tremmel, Filippa Schreeck, Simon Jaeger, Severin Schricker, Elke Schaeffeler, Svitlana Igel, Daniela Steinberger, Manuel Pagitz, Jörg Latus, Markus Ketteler, Kerstin Bühl, Marc‐H. Dahlke, Hans‐Georg Kopp, Matthias Schwab   +13 more
wiley   +1 more source