Results 11 to 20 of about 669,596 (277)
European Journal of Pharmacology, 2008 Trace amine-associated receptors, a novel class of G-protein coupled receptors which respond to trace amines but not to classical biogenic amines, have been found to be expressed in heart. Therefore, we investigated the cardiac effects of the trace amines p-tyramine, beta-phenylethylamine, octopamine, and tryptamine.
FRASCARELLI S +7 more
openaire +4 more sources
Actions of Trace Amines in the Brain-Gut-Microbiome Axis via Trace Amine-Associated Receptor-1 (TAAR1). [PDF]
Cell Mol Neurobiol, 2020 Trace amines and their primary receptor, Trace Amine-Associated Receptor-1 (TAAR1) are widely studied for their involvement in the pathogenesis of neuropsychiatric disorders despite being found in the gastrointestinal tract at physiological levels.
Bugda Gwilt K +7 more
europepmc +3 more sources
Trace Amines and Trace Amine-Associated Receptors: A New Frontier in Cell Signaling. [PDF]
Cell Mol Neurobiol, 2020 Trace amines, including β-phenylethylamine, p-octopamine, p-tyramine, and tryptamine, are produced in high levels in invertebrates where they play major roles in homeostasis regulation in a manner similar to that of adrenergic systems in mammals (Rutigliano et al. in Front Pharmacol 8:987, 2017; Gainetdinov et al.
Freyberg Z, Saavedra JM.
europepmc +3 more sources
Trace amines and cocaine abuse. [PDF]
ACS Chem Neurosci, 2014 Cocaine addiction remains a clinical challenge with no effective pharmacotherapy available. Trace amine associated receptor (TAAR) 1 represents a promising drug target for the modulation of dopaminergic system and stimulant abuse. This Viewpoint discusses the emerging data which strongly suggest that TAAR 1 functions as a molecular "brake" that ...
Li JX.
europepmc +3 more sources
Pharmacology of vascular responses to trace amines [PDF]
Trace amines including β-Phenylethylamine (β-PEA) and tyramine are vasoactive monoamines closely related to the classical neurotransmitters, noradrenaline, serotonin (5-HT) and dopamine.
Voisey, Alexander
core +6 more sources
Differential mechanisms of action of the trace amines octopamine, synephrine and tyramine on the porcine coronary and mesenteric artery. [PDF]
Sci Rep, 2019 Trace amines such as p-tyramine, p-octopamine and p-synephrine are found in low concentrations in animals and plants. Consumption of pre-workout supplements containing these plant-derived amines has been associated with cardiovascular side effects.
Koh AHW, Chess-Williams R, Lohning AE.
europepmc +2 more sources
Trace Amines and Their Receptors [PDF]
Pharmacological Reviews, 2018 Trace amines are endogenous compounds classically regarded as comprising β-phenylethyalmine, p-tyramine, tryptamine, p-octopamine, and some of their metabolites. They are also abundant in common foodstuffs and can be produced and degraded by the constitutive microbiota.
Raul R, Gainetdinov +2 more
openaire +2 more sources
Ultrasensitive Detection of Amines by a Trace Amine-Associated Receptor [PDF]
The Journal of Neuroscience, 2013 The mammalian main olfactory pathway detects volatile chemicals using two families of G-protein-coupled receptors: a large repertoire of canonical odorant receptors and a much smaller set of trace amine-associated receptors (TAARs). The TAARs are evolutionarily conserved in vertebrates, including humans, suggesting an indispensible role in olfaction ...
Jingji, Zhang +4 more
openaire +4 more sources
Following the trace of elusive amines [PDF]
Proceedings of the National Academy of Sciences, 2001 The classical biogenic amines (serotonin, noradrenaline, dopamine, and histamine) play important roles as neuromodulators. These transmitters are synthesized from precursor amino acids in specific neurons and stored in vesicles at synaptic terminals for release into the synaptic cleft in response to neuronal depolarization.
R T, Premont +2 more
openaire +2 more sources
Frontiers in Neural Circuits, 2023 Interkingdom signalling within a holobiont allows host and symbionts to communicate and to regulate each other’s physiological and developmental states.
Xueyan Xiang +5 more
doaj +1 more source