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Trained Immunity Confers Broad-Spectrum Protection Against Bacterial Infections [PDF]
Journal of Infectious Diseases, 2020 Contains fulltext : 229526.pdf (Publisher’s version ) (Open Access)BACKGROUND: The innate immune system recalls a challenge to adapt to a secondary challenge, a phenomenon called trained immunity.
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Nature Reviews Immunology, 2020
New research suggests that haematopoietic stem cells (HSCs) can contribute to trained immunity. Stimulation with lipopolysaccharide establishes long-lasting epigenetic changes in HSCs that confer improved responsiveness to secondary stimulation.
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New research suggests that haematopoietic stem cells (HSCs) can contribute to trained immunity. Stimulation with lipopolysaccharide establishes long-lasting epigenetic changes in HSCs that confer improved responsiveness to secondary stimulation.
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Trained immunity in the mucosal diseases
WIREs Mechanisms of Disease, 2021AbstractImmune memory is well known as a signature of the adaptive immune system. Recently, enhanced responses to subsequent triggers are also observed in innate immune system, termed trained immunity (TI). Awakening of innate immune memory is required for host defense, such as anti‐pathogen and anti‐tumor responses.
Dou Yu, Jiaqi Zhang, Shuo Wang
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Nature Reviews Immunology, 2018
Nanoparticles designed to prevent training of myeloid cells infiltrating allografts can promote long-term transplant acceptance and immunological tolerance.
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Nanoparticles designed to prevent training of myeloid cells infiltrating allografts can promote long-term transplant acceptance and immunological tolerance.
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Recent research has increasingly highlighted the adaptive characteristics of the innate immune system, revealing its capacity for a heterologous memory of previous infections. Allergen-specific immunotherapy (AIT) has demonstrated that innate immune cells, such as monocytes, macrophages, and natural killer (NK) cells, can provide protection against ...
Sayanti, Pal +6 more
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Sayanti, Pal +6 more
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Marathon Training and Immune Function
Sports Medicine, 2007Many components of the immune system exhibit adverse change after marathon-type exertion. These immune changes occur in several compartments of the immune system and body (e.g. the skin, upper respiratory tract mucosal tissue, lung, peritoneal cavity, blood and muscle). Of all immune cells, natural killer (NK) cells, neutrophils and macrophages (of the
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Vaccinations have significantly reduced mortality from infectious diseases by preparing the immune system for pathogens without causing illness. In addition to specific protection, some vaccines can also have non-specific effects (NSE), offering broader protection against various infections.
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The role of trained immunity in COVID-19: Lessons for the next pandemic
Cell Host and Microbe, 2023Athanasios Ziogas
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Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity
Cell, 2018Alessandra Palladini +2 more
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