Results 71 to 80 of about 1,089,122 (265)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination

, 2022
The antituberculosis vaccine Bacillus Calmette–Guérin (BCG) induces nonspecific protection against heterologous infections, at least partly through induction of innate immune memory (trained immunity).
Mourits, Vera P., Cheng-Jian Xu, Koeken, Valerie A. C. M., Valerie A C M Koeken, Vera P Mourits, Moorlag, Simone J. C. F. M., Helga Dijkstra, de Bree, L. Charlotte J., van Laarhoven, Arjan, Heidi Lemmers, Reinout van Crevel, Xu, Cheng-Jian, Cancan Qi, Mihai G Netea, van Crevel, Reinout, Qi, Cancan, Joosten, Leo A. B., Arjan van Laarhoven, Lemmers, Heidi, Netea, Mihai G., Yang Li, Vidhisha Sonawane, Leo A B Joosten, L Charlotte J de Bree, Li, Yang, Sonawane, Vidhisha, Dijkstra, Helga, Simone J C F M Moorlag   +27 more
core   +1 more source

Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections

Journal for ImmunoTherapy of Cancer, 2023
Background BCG is recommended as intravesical immunotherapy to reduce the risk of tumor recurrence in patients with non-muscle invasive bladder cancer (NMIBC). Currently, it is unknown whether intravesical BCG application induces trained immunity.Methods
J Alfred Witjes, Alina Vrieling, Mihai G Netea, Leo A B Joosten, Katja K H Aben, Sita H Vermeulen, Joost L Boormans, Antoine G van der Heijden, Boris Novakovic, Jelmer H van Puffelen, Liesbeth van Emst, Denise Kooper, Tahlita C M Zuiverloon, Ursula T H Oldenhof, Tessel E Galesloot, Lambertus A L M Kiemeney, Egbert Oosterwijk   +16 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Involvement of trained immunity during autoimmune responses

, 2023
Recently, it has been described that innate immune cells such as monocytes, macrophages, and natural killer cells can develop a non-specific immune response induced by different stimuli, including lipopolysaccharides, Mycobacterium bovis Bacillus ...
Ricardo A. Loaiza, Bohmwald, Karen, Kalergis, Alexis M., Alexis M. Kalergis, Soto, Jorge A., Jorge A. Soto, Karen Bohmwald, Mora, Valentina P., Valentina P. Mora, Loaiza, Ricardo A.   +9 more
core   +1 more source

The double-edged nature of trained immunity

eLife
Trained immunity in alveolar macrophages can lead to damaging lung inflammation, confirming the importance of context in this phenomenon.
Chrissy M Leopold Wager, Larry S Schlesinger   +1 more
doaj   +1 more source

A century of BCG vaccination: Immune mechanisms, animal models, non-traditional routes and implications for COVID-19

Frontiers in Immunology, 2022
Bacillus Calmette-Guerin (BCG) has been used as a vaccine against tuberculosis since 1921 and remains the only currently approved vaccine for this infection.
Shivani Singh, Shivani Singh, Shivani Singh, Noemi Alejandra Saavedra-Avila, Sangeeta Tiwari, Steven A. Porcelli, Steven A. Porcelli   +6 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Trained immunity suppression determines kidney allograft survival [PDF]

The innate immune system plays an essential role in regulating the immune responses to kidney transplantation, but the mechanisms through which innate immune cells influence long-term graft survival are unclear.
Duivenvoorden, Raphaël, Ochando, Jordi, van der Vlag, Johan, Baltissen, Marijke, Mulder, Willem J.M., van den Hoogen, Martijn W.F.; id_orcid, Mhlanga, Musa M., Madsen, Joren C., Rother, Nils, Netea, Mihai G., Fayad, Zahi A., Jonkman, Inge, Teunissen, Abraham J.P., Joosten, Leo A.B., Martens, Joost H.A., van den Hoogen, Martijn W.F., Baas, Marije, Negishi, Yutaka, Hilbrands, Luuk B., Yanginlar, Cansu, Jacobs, Maaike M.E., Vermeulen, Michiel   +21 more
core   +1 more source

EZH2 identifies the precursors of human natural killer cells with trained immunity

Cancer Biology & Medicine, 2021
Objective: Trained immunity of natural killer (NK) cells has shown great potential in the treatment of cancers by eliciting enhanced effector responses to restimulation by cytokines or cancer cells for long time periods after preactivation.
Chen Zhang, Jie Yin, Jian Zheng, Jun Xiao, Jiajian Hu, Yudong Su, Kaichen Zhou, Yingchi Zhang, Xuzhen Zhang, Hong Zhang, Qian Sun, Yang Wang, Wenwen Yu, Feng Wei, Qiang Zhao, Long Li, Xiubao Ren   +16 more
doaj   +1 more source