Results 81 to 90 of about 1,089,122 (265)

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Mycobacterium manresensis induces trained immunity in vitro [PDF]

, 2023
The COVID-19 pandemic posed a global health crisis, with new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants weakening vaccine-driven protection. Trained immunity could help tackle COVID-19 disease.
López-Serrano, Sergi, Martín, Berta, Maria-Rosa Sarrias, Lidia Sanchez-Moral, Jordana Muñoz-Basagoiti, Pere-Joan Cardona, Perez-Zsolt, Daniel, Izquierdo Useros, Nuria, Alhelí Rodríguez-Cortés, Marta Arch-Sisquella, Pere Torán-Monserrat, Salvador, Betlem, Violán, Concepció, Morros, Rosa, Sergi López-Serrano, Vilaplana Massaguer, Cristina, Monfà, Ramon, Berta Martín, Segalés Coma, Joaquim, Sanchez-Moral, Lidia, Miquel de Homdedeu, Concepció Violán, Ràfols, Neus, Rosa Morros, Betlem Salvador, Cardona, Pere-Joan, Joan Matllo, Sarrias, Maria-Rosa, Joaquim Segalés, Neus Ràfols, Miguel A. Peinado, Rodriguez-Cortes, Alheli, Ouchi, Dan, Nuria Izquierdo-Useros, Cristina Vilaplana, de Homdedeu, Miquel, Daniel Perez-Zsolt, Torán Montserrat, Pere, Muñoz-Basagoiti, Jordana, Ramon Monfà, Dan Ouchi, Peinado, Miguel A., Arch Sisquella, Marta, Matllo, Joan   +43 more
core   +1 more source

Microglial Priming as Trained Immunity in the Brain [PDF]

Neuroscience, 2019
In this review we discuss the possibility that the phenomenon of microglial priming can be explained by the mechanisms that underlie trained immunity. The latter involves the enhancement of inflammatory responses by epigenetic mechanisms that are mobilized after first exposure to an inflammatory stimulus.
Haley, Michael, Brough, David, Quintin, Jessica, Allan, Stuart   +3 more
openaire   +4 more sources

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Trained Immunity and Local Innate Immune Memory in the Lung [PDF]

Cell, 2018
Trained innate immunity mediates protection against heterologous infections and is mediated by epigenetic and functional reprogramming of myeloid cells and their progenitors. Now, Yao et al. describe trained immunity induced locally in alveolar macrophages by a viral infection, with IFNγ release from effector CD8+ lymphocytes initiating this process.
Netea, M.G., Netea, M.G., Joosten, L.A.B., Joosten, L.A.B.   +3 more
openaire   +3 more sources

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

17β-Estradiol Promotes Trained Immunity in Females Against Sepsis via Regulating Nucleus Translocation of RelB

Frontiers in Immunology, 2020
Sepsis is more common among males than females, and the unequal estrogen levels have been suspected to play a vital role in gender differences. Recently, trained immunity is reported to be a novel strategy for the innate immune system to fight infection.
Zhiheng Sun, Yuchen Pan, Junxing Qu, Yujun Xu, Huan Dou, Huan Dou, Yayi Hou, Yayi Hou   +7 more
doaj   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Trained immunity and inflammation in rheumatic diseases [PDF]

, 2022
BACKGROUND: Rheumatic diseases include a variety of autoimmune and autoinflammatory conditions that are characterised by musculoskeletal involvement and systemic disease.
Badii, O.M., Gaal, O., Popp, R.A., Crișan, T.O., Joosten, L.A.B.   +4 more
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