Results 71 to 80 of about 21,301 (157)

Metaplasia and the Origins of Gastric Cancer—Implications for Screening and Surveillance

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Gastric intestinal metaplasia (IM) is a key step in the development of intestinal‐type gastric cancer (GC) and a checkpoint for preventive strategies. The risk of progression to GC is highest for incomplete IM and extensive severe IM as classified by scoring systems such as operative link on gastric intestinal metaplasia (OLGIM) assessment ...
Khay Guan Yeoh
wiley   +1 more source

Pediatric Langerhans Cell Histiocytosis Presenting With Bilateral Parotid Gland Swelling and Cystic Lung Disease: A Case Report and Literature Review

Pediatric Dermatology, EarlyView.
ABSTRACT Langerhans cell histiocytosis (LCH) is a neoplastic process originating from immature myeloid precursor cells. In this report, we describe a case of a 17‐month‐old with scaling of the scalp and swelling of the bilateral parotid glands who developed acute respiratory distress.
Aretha On, Robert Smith, Robert Duffy, Maria B. Queenan, Melinda Jen   +4 more
wiley   +1 more source

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, Volume 200, Issue 11, Page 2568-2574, November 2026.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source

High Level of Component C1q Binding Protein (C1QBP) is Associated With Poor Prognosis and Dysfunction of Mast Cells in Lung Adenocarcinoma

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Background Component C1q binding protein (C1QBP) is known as an important regulator of mitochondrial plasticity and is involved in antitumor immune response in cancers. Nevertheless, its role in lung adenocarcinoma (LUAD) still remains largely unknown.
Wei Li, Guangnan Huang, Lizhong Zeng, Wenhui Dang, Ting Jiao, Yonghong Zhang, Mengying Zhang, Shuru Zhou, Liping Chen, Shuanying Yang   +9 more
wiley   +1 more source

Genomic Alterations in Pulmonary Carcinoid Tumors: A Targeted Analysis of Gene Rearrangements and Oncogenic Mutations

Cancer Medicine, Volume 15, Issue 11, November 2026.
This study applied RNA‐based next‐generation sequencing to one of the largest cohorts of pulmonary carcinoid tumors analyzed to date and revealed rare yet potentially actionable gene rearrangements and variants, including alterations in ALK, BRAF, and EGFR.
Jenni Niinimäki, Soili Kytölä, Ari Ristimäki, Johanna Arola, Tiina Vesterinen   +4 more
wiley   +1 more source

Genome Sequencing Outperforms Exome Sequencing in Formalin‐Fixed Paraffin Embedded Tumors Leading to Improved Treatment Options

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Precision oncology is based on comprehensive molecular characterization of a patient's tumor. This is mostly realized by next‐generation sequencing panels or exome sequencing. Data on the value of genome sequencing from formalin‐fixed paraffin embedded (FFPE) material in a clinical setting is still scarce.
Nadja Ballin, Alexander Ott, Michaela Pogoda, Florian Harmuth, Vijay Kumar Ulaganathan, Anton Karelin, Cristiana Roggia, Irina Bonzheim, Stephan Singer, Holly Sundberg‐Malek, Pavlos Missios, Stephan Ossowski, Tobias B. Haack, Olaf Riess, Michael Bitzer, Nisar Malek, Christopher Schroeder, Sorin Armeanu‐Ebinger   +17 more
wiley   +1 more source

Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction

Platelets, 2019
The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone.
Amanda J. Unsworth, Alexander P. Bye, Neline Kriek, Tanya Sage, Ashley A. Osborne, Dillon Donaghy, Jonathan M. Gibbins   +6 more
doaj   +1 more source

Surgical Management and Outcomes of Relapsed and Refractory Hepatoblastoma: An Institutional Case Series

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Relapse occurs in 10%–20% of children with hepatoblastoma and is associated with inferior outcomes, yet standardized management remains limited. Defining risk factors and relapse patterns, as well as the role of surgery, particularly transplantation, is critical to optimizing survival. A retrospective review was performed of patients aged 0–18 
Marissa Ray, Alyssa Stetson, Nicolas Noriega, Stephen Hartman, Colton Brown, Emily Schepers, Zishaan Farooqui, Alexander J. Towbin, Katherine M. Somers, Sarangarajan Ranganathan, James Geller, Sue Evans, Jonathan Merola, Alexander J. Bondoc, Greg Tiao   +14 more
wiley   +1 more source

Targeting MET and KRAS G12C co-occurring mutation in metastatic adenoid cystic carcinoma of the trachea: a case report

Journal of Medical Case Reports
Background MET and KRAS comutation in the same group of cells of primary tracheal adenoid cystic carcinoma is extremely rare; there is no standard of care for patient with metastatic disease.
Ling Zhang, Tonghui Wang, Yan Xu, Youxin Ji, Keke Nie   +4 more
doaj   +1 more source

Encorafenib‐associated acantholytic dermatosis in collision with eccrine squamous syringometaplasia

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Francisco Meraz‐Torres, Gabi Handgretinger, Andreas Meiwes, Derya Durak, Joana Schroth, Stephan Forchhammer   +5 more
wiley   +1 more source