Results 1 to 10 of about 54,454 (182)

Transcriptional responses to proteotoxic stressors are profoundly diverse and tissue-specific [PDF]

Cell Stress & Chaperones
Cells counteract proteotoxic conditions by launching transcriptional stress responses. While synthesis of heat shock proteins (HSPs) upon acute stress is well characterized, how distinct proteotoxic conditions reshape the transcriptome remains poorly ...
Adelina Rabenius, Intisar Salim, Hilmar Lindström, Anastasiya Pak, Serhat Aktay, Anniina Vihervaara   +5 more
doaj   +2 more sources

FSHR Trans-Activation and Oligomerization [PDF]

Frontiers in Endocrinology, 2018
Follicle stimulating hormone (FSH) plays a key role in human reproduction through, among others, induction of spermatogenesis in men and production of estrogen in women. The function FSH is performed upon binding to its cognate receptor-follicle-stimulating hormone receptor (FSHR) expressed on the surface of target cells (granulosa and Sertoli cells ...
Kamila Szymańska, Joanna Kałafut, Alicja Przybyszewska, Beata Paziewska, Grzegorz Adamczuk, Michał Kiełbus, Adolfo Rivero-Müller, Adolfo Rivero-Müller   +7 more
openaire   +3 more sources

Liver fat storage is controlled by HNF4α through induction of lipophagy and is reversed by a potent HNF4α agonist

Cell Death and Disease, 2021
We report the discovery of strong HNF4α agonists and their use to uncover a previously unknown pathway by which HNF4α controls the level of fat storage in the liver.
Seung-Hee Lee, Vimal Veeriah, Fred Levine   +2 more
doaj   +1 more source

Fumarate analogs act as allosteric inhibitors of the human mitochondrial NAD(P)+-dependent malic enzyme. [PDF]

PLoS ONE, 2014
Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) is allosterically activated by the four-carbon trans dicarboxylic acid, fumarate. Previous studies have suggested that the dicarboxylic acid in a trans conformation around the carbon-carbon
Ju-Yi Hsieh, Jyung-Hurng Liu, Pai-Chun Yang, Chi-Li Lin, Guang-Yaw Liu, Hui-Chih Hung   +5 more
doaj   +1 more source

ZmOrphan94 Transcription Factor Downregulates ZmPEPC1 Gene Expression in Maize Bundle Sheath Cells

Frontiers in Plant Science, 2021
Spatial separation of the photosynthetic reactions is a key feature of C4 metabolism. In most C4 plants, this separation requires compartmentation of photosynthetic enzymes between mesophyll (M) and bundle sheath (BS) cells.
Alicja M. Górska, Alicja M. Górska, Paulo Gouveia, Paulo Gouveia, Ana Rita Borba, Ana Rita Borba, Anna Zimmermann, Anna Zimmermann, Anna Zimmermann, Tânia S. Serra, Tânia S. Serra, Pedro Carvalho, Tiago F. Lourenço, Tiago F. Lourenço, M. Margarida Oliveira, M. Margarida Oliveira, Christoph Peterhänsel, Nelson J. M. Saibo, Nelson J. M. Saibo   +18 more
doaj   +1 more source

Genome-wide characterization of FK506-binding proteins, parvulins and phospho-tyrosyl phosphatase activators in wheat and their regulation by heat stress

Frontiers in Plant Science, 2022
Peptidyl-prolyl cis-trans isomerases (PPIases) are ubiquitous proteins which are essential for cis-trans isomerisation of peptide bonds preceding the proline residue.
Anantika Suri, Harpreet Singh, Kirandeep Kaur, Anish Kaachra, Prabhjeet Singh   +4 more
doaj   +1 more source

Structural basis of Janus kinase trans-activation

Cell Reports, 2023
Janus kinases (JAKs) mediate signal transduction downstream of cytokine receptors. Cytokine-dependent dimerization is conveyed across the cell membrane to drive JAK dimerization, trans-phosphorylation, and activation. Activated JAKs in turn phosphorylate receptor intracellular domains (ICDs), resulting in the recruitment, phosphorylation, and ...
Nathanael A. Caveney, Robert A. Saxton, Deepa Waghray, Caleb R. Glassman, Naotaka Tsutsumi, Stevan R. Hubbard, K. Christopher Garcia   +6 more
openaire   +3 more sources

Genome-wide characterization of peptidyl-prolyl  cis–trans  isomerases in Penicillium and their regulation by salt stress in a halotolerant P. oxalicum

Scientific Reports, 2021
Peptidyl-prolyl cis–trans isomerases (PPIases) are the only class of enzymes capable of cis–trans isomerization of the prolyl peptide bond. The PPIases, comprising of different families viz., cyclophilins, FK506-binding proteins (FKBPs), parvulins and ...
Mangaljeet Singh, Kirandeep Kaur, Avinash Sharma, Rajvir Kaur, Dimple Joshi, Megha Chatterjee, Iman Dandapath, Amarjeet Kaur, Harpreet Singh, Prabhjeet Singh   +9 more
doaj   +1 more source

Cis and trans effects differentially contribute to the evolution of promoters and enhancers

Genome Biology, 2020
Background Gene expression differences between species are driven by both cis and trans effects. Whereas cis effects are caused by genetic variants located on the same DNA molecule as the target gene, trans effects are due to genetic variants that affect
Kaia Mattioli, Winona Oliveros, Chiara Gerhardinger, Daniel Andergassen, Philipp G. Maass, John L. Rinn, Marta Melé   +6 more
doaj   +1 more source

Trans-activating mutations of the pseudokinase ERBB3

Oncogene, 2023
Abstract Genetic changes in the ERBB family of receptor tyrosine kinases serve as oncogenic driver events and predictive biomarkers for ERBB inhibitor drugs. ERBB3 is a pseudokinase member of the family that, although lacking a fully active kinase domain, is well known for its potent signaling activity as a heterodimeric complex with ERBB2 ...
Marika K. A. Koivu, Deepankar Chakroborty, Tomi T. Airenne, Mark S. Johnson, Kari J. Kurppa, Klaus Elenius   +5 more
openaire   +2 more sources