Results 11 to 20 of about 3,929,670 (363)
Trans-activating mutations of the pseudokinase ERBB3
Oncogene, 2023 Abstract Genetic changes in the ERBB family of receptor tyrosine kinases serve as oncogenic driver events and predictive biomarkers for ERBB inhibitor drugs. ERBB3 is a pseudokinase member of the family that, although lacking a fully active kinase domain, is well known for its potent signaling activity as a heterodimeric complex with ERBB2 ...
Marika K. A. Koivu +5 more
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FSHR Trans-Activation and Oligomerization [PDF]
Frontiers in Endocrinology, 2018 Follicle stimulating hormone (FSH) plays a key role in human reproduction through, among others, induction of spermatogenesis in men and production of estrogen in women. The function FSH is performed upon binding to its cognate receptor-follicle-stimulating hormone receptor (FSHR) expressed on the surface of target cells (granulosa and Sertoli cells ...
Adolfo Rivero-Müller +7 more
openaire +4 more sources
Structural basis of Janus kinase trans-activation
Cell Reports, 2023 Janus kinases (JAKs) mediate signal transduction downstream of cytokine receptors. Cytokine-dependent dimerization is conveyed across the cell membrane to drive JAK dimerization, trans-phosphorylation, and activation. Activated JAKs in turn phosphorylate receptor intracellular domains (ICDs), resulting in the recruitment, phosphorylation, and ...
Nathanael A. Caveney +6 more
openaire +3 more sources
Cell Death and Disease, 2021 We report the discovery of strong HNF4α agonists and their use to uncover a previously unknown pathway by which HNF4α controls the level of fat storage in the liver.
Seung-Hee Lee +2 more
doaj +1 more source
Transcriptomic effects of Tet-on and mifepristone-inducible systems in mouse liver [PDF]
, 2008 Control of transgene expression from long-term expression vectors can be achieved with inducible and regulated promoters. The two most commonly used inducible systems employ doxycycline or mifepristone as the drug activating a silent trans-activator ...
Reboredo, M. (Mercedes) +4 more
core +3 more sources
Fumarate analogs act as allosteric inhibitors of the human mitochondrial NAD(P)+-dependent malic enzyme. [PDF]
PLoS ONE, 2014 Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) is allosterically activated by the four-carbon trans dicarboxylic acid, fumarate. Previous studies have suggested that the dicarboxylic acid in a trans conformation around the carbon-carbon
Ju-Yi Hsieh +5 more
doaj +1 more source
Frontiers in Plant Science, 2022 Peptidyl-prolyl cis-trans isomerases (PPIases) are ubiquitous proteins which are essential for cis-trans isomerisation of peptide bonds preceding the proline residue.
Anantika Suri +4 more
doaj +1 more source
ZmOrphan94 Transcription Factor Downregulates ZmPEPC1 Gene Expression in Maize Bundle Sheath Cells
Frontiers in Plant Science, 2021 Spatial separation of the photosynthetic reactions is a key feature of C4 metabolism. In most C4 plants, this separation requires compartmentation of photosynthetic enzymes between mesophyll (M) and bundle sheath (BS) cells.
Alicja M. Górska +18 more
doaj +1 more source
A trans-activator-like structure in RCNMV RNA1 evokes the origin of the trans-activator in RNA2
PLOS Pathogens, 2020 The Red clover necrotic mosaic virus (RCNMV) genome consists of two plus-strand RNA genome segments, RNA1 and RNA2. RNA2 contains a multifunctional RNA structure known as the trans-activator (TA) that (i) promotes subgenomic mRNA transcription from RNA1, (ii) facilitates replication of RNA2, and (iii) mediates particle assembly and copackaging of ...
Laura R. Newburn, K. Andrew White
openaire +5 more sources
Scientific Reports, 2021 Peptidyl-prolyl cis–trans isomerases (PPIases) are the only class of enzymes capable of cis–trans isomerization of the prolyl peptide bond. The PPIases, comprising of different families viz., cyclophilins, FK506-binding proteins (FKBPs), parvulins and ...
Mangaljeet Singh +9 more
doaj +1 more source