Results 11 to 20 of about 54,454 (182)
Transcriptomic effects of Tet-on and mifepristone-inducible systems in mouse liver [PDF]
, 2008 Control of transgene expression from long-term expression vectors can be achieved with inducible and regulated promoters. The two most commonly used inducible systems employ doxycycline or mifepristone as the drug activating a silent trans-activator ...
Reboredo, M. (Mercedes) +4 more
core +3 more sources
PLoS ONE, 2020 Chromatin structure plays a decisive role in gene regulation through the actions of transcriptional activators, coactivators, and epigenetic machinery.
Michelle Esposito +5 more
doaj +1 more source
Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa. [PDF]
PLoS ONE, 2015 Transient receptor potential ankyrin1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) are members of the TRP superfamily of structurally related, nonselective cation channels and mediators of several signaling pathways.
Hana Moon +8 more
doaj +1 more source
mRNA trans-splicing dual AAV vectors for (epi)genome editing and gene therapy
Nature Communications, 2023 Large genes including several CRISPR-Cas modules like gene activators (CRISPRa) require dual adeno-associated viral (AAV) vectors for an efficient in vivo delivery and expression.
Lisa Maria Riedmayr +20 more
doaj +1 more source
Programmable RNA detection with CRISPR-Cas12a
Nature Communications, 2023 Cas12a, a CRISPR-associated protein complex, has an inherent ability to cleave DNA substrates and is utilized in diagnostic tools to identify DNA molecules. We demonstrate that multiple orthologs of Cas12a activate trans-cleavage in the presence of split
Santosh R. Rananaware +8 more
doaj +1 more source
Gene activation by a CRISPR-assisted trans enhancer
eLife, 2019 The deactivated CRISPR/Cas9 (dCas9) is now the most widely used gene activator. However, current dCas9-based gene activators are still limited by their unsatisfactory activity.
Xinhui Xu +5 more
doaj +1 more source
Intranuclear topological distribution of HIV‐1 trans‐activators [PDF]
FEBS Letters, 1992 Subcellular localization of human immunodeficiency virus type 1 (HIV‐1) Tat and Rev was examined using a confocal laser scanning microscope (CLSM). In transfected COS‐7 cells, Tat resided exclusively in the perinocleolar region, while Rev infiltrated fully into the nucleoli.
Miyazaki, Yukio +4 more
openaire +2 more sources
RNF12 activates Xist and is essential for X chromosome inactivation. [PDF]
PLoS Genetics, 2011 In somatic cells of female placental mammals, one of the two X chromosomes is transcriptionally silenced to accomplish an equal dose of X-encoded gene products in males and females.
Tahsin Stefan Barakat +9 more
doaj +1 more source
Synergy between HIV-1 Tat and adenovirus E1A is principally due to stabilization of transcriptional elongation [PDF]
, 1990 We studied the combined effects of Tat and general trans-activators, such as E1A and phorbol esters, on human immunodeficiency virus-1 (HIV-1) gene expression. Interaction between these two types of trans-activators may be involved in the transition from
Laspia, M. F. +2 more
core +1 more source
Signal Transduction and Targeted Therapy, 2023 Cancer cell receives extracellular signal inputs to obtain a stem-like status, yet how tumor microenvironmental (TME) neural signals steer cancer stemness to establish the hierarchical tumor architectures remains elusive.
Bin He +22 more
doaj +1 more source