Trans-activation of heparanase promoter by ETS transcription factors [PDF]
Oncogene, 2003 The remodeling of extracellular matrix (ECM) is an important process required for cancer cells to turn into invasive and metastatic cancer cells. To dissolve the protein components of ECM, matrix metalloproteinases are some of the essential enzymes. Another ECM remodeling enzyme is the heparanase (Hpa) that digests the heparin sulfate component of the ...
W C, Lu, Y N, Liu, B B, Kang, J H, Chen
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Towards combinatorial transcriptional engineering [PDF]
, 2017 The modular nature of the transcriptional unit makes it pos sible to design robust modules with predictable input -output characteristics using a ‘parts - off a shelf’ approach.
Kanodia, Harsh +4 more
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Conservation of the TRAPPII-specific subunits of a Ypt/Rab exchanger complex
BMC Evolutionary Biology, 2007 Background Ypt/Rab GTPases and their GEF activators regulate intra-cellular trafficking in all eukaryotic cells. In S. cerivisiae, the modular TRAPP complex acts as a GEF for the Golgi gatekeepers: Ypt1 and the functional pair Ypt31/32.
Yoo Eunice +3 more
doaj +1 more source
The MHC-II transactivator CIITA, a restriction factor against oncogenic HTLV-1 and HTLV-2 retroviruses: similarities and differences in the inhibition of Tax-1 and Tax-2 viral transactivators [PDF]
, 2013 The activation of CD4(+) T helper cells is strictly dependent on the presentation of antigenic peptides by MHC class II (MHC-II) molecules. MHC-II expression is primarily regulated at the transcriptional level by the AIR-1 gene product CIITA (class II ...
Abdallah, R. +3 more
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EPAS1 trans-Activation during Hypoxia Requires p42/p44 MAPK [PDF]
Journal of Biological Chemistry, 1999 Hypoxia is a common environmental stress that regulates gene expression and cell function. A number of hypoxia-regulated transcription factors have been identified and have been shown to play critical roles in mediating cellular responses to hypoxia. One of these is the endothelial PAS-domain protein 1 (EPAS1/HIF2-alpha/HLF/HRF).
P W, Conrad +3 more
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FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
EgMYB2, a new transcriptional activator from Eucalyptus xylem, regulates secondary cell wall formation and lignin biosynthesis [PDF]
, 2005 International audienceEgMYB2, a member of a new subgroup of the R2R3 MYB family of transcription factors, was cloned from a library consisting of RNA from differentiating Eucalyptus xylem.
Chaubet-Gigot, Nicole +10 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The Skn7 Response Regulator of \u3ci\u3eSaccharomyces cerevisiae\u3c/i\u3e Interacts with Hsf1 In Vivo and Is Required for the Induction of Heat Shock Genes by Oxidative Stress [PDF]
, 2000 The Skn7 response regulator has previously been shown to play a role in the induction of stress-responsive genes in yeast, e.g., in the induction of the thioredoxin gene in response to hydrogen peroxide.
Erkine, Alexander M. +6 more
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Articulations and controversies in sex-work trans-activism [PDF]
Critical Social Policy, 2020 Beatriz Espejo has worked in Barcelona as a trans-sex-worker since the 1980s, and in 1993 she founded the CTC, one of the leading activist organisations in the Spanish trans movement during the ’00s. The CTC had a direct impact on the definition of the Spanish law on gender identity.
Beatriz Espejo +2 more
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