In vivo antiangiogenic effect of nimbolide, trans-chalcone and piperine for use against glioblastoma [PDF]
BMC Cancer, 2023 Background Angiogenesis is an important hallmark of Glioblastoma (GBM) marked by elevated vascular endothelial growth factor-A (VEGF-A) and its receptor 2 (VEGFR-2).
Anna Senrung +9 more
doaj +7 more sources
Effect of silibinin and trans-chalcone in an Alzheimer's disease-like model generated by insulin amyloids [PDF]
Brazilian Journal of Medical and Biological Research, 2023 Amyloid fibrils are characteristic of several disorders including Alzheimer's disease (AD), with no cure or preventive therapy. Diminishing amyloid deposits using aromatic compounds is an interesting approach toward AD treatment.
M. Omidi-Shahsavandi +3 more
doaj +7 more sources
Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition. [PDF]
PLoS ONE, 2018 Naturally-occurring chalcones and synthetic chalcone analogues have been demonstrated to have many biological effects, including anti-inflammatory, anti-malarial, anti-fungal, and anti-oxidant/anti-cancerous activities. Compared to other chalcones, trans-
Gabriel Silva +13 more
doaj +9 more sources
The effects of trans-chalcone and chalcone 4 hydrate on the growth of Babesia and Theileria. [PDF]
PLoS Neglected Tropical Diseases, 2019 BackgroundChemotherapy is a principle tool for the control and prevention of piroplasmosis. The search for a new chemotherapy against Babesia and Theileria parasites has become increasingly urgent due to the toxic side effects of and developed resistance
Gaber El-Saber Batiha +6 more
doaj +8 more sources
Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice [PDF]
Frontiers in Pharmacology, 2018 Gouty arthritis is characterized by an intense inflammatory response to monosodium urate crystals (MSU), which induces severe pain and reduction in the life quality of patients.
Larissa Staurengo-Ferrari +12 more
doaj +8 more sources
Characterization of a Natural, Stable, Reversible and Colourful Anthocyanidin Network from Sphagnum Moss Based Mainly on the Yellow Trans-Chalcone and Red Flavylium Cation Forms [PDF]
Molecules, 2021 Anthocyanins with various functions in nature are one of the most important sources of colours in plants. They are based on anthocyanidins or 3-deoxyanthocyanidins having in common a C15-skeleton and are unique in terms of how each anthocyanidin is ...
Helge Berland, Øyvind M. Andersen
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Trans-chalcone suppresses tumor growth mediated at least in part by the induction of heme oxygenase-1 in breast cancer. [PDF]
Toxicol Res, 2021 Despite intensive research efforts in recent decades, cancer remains a leading cause of death worldwide. The chalcone family is a promising group of phytochemicals for therapeutic use against cancer development.
Komoto TT +6 more
europepmc +7 more sources
Hepatoprotective and antifibrotic effects of trans-chalcone against bile duct ligation-induced liver fibrosis in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Several lines of research have shown that hepatic fibrosis is one of the leading causes of death worldwide. Trans-chalcone is a flavonoid precursor with anti-oxidant and anti-inflammatory effects.
Faezeh Javadi +5 more
doaj +5 more sources
Exploring the Therapeutic Potential of trans-Chalcone: Modulation of MicroRNAs Linked to Breast Cancer Progression in MCF-7 Cells. [PDF]
Int J Mol Sci, 2023 Breast cancer is responsible for 25% of all cancers that affect women. Due to its high heterogeneity pattern in clinical diagnosis and its molecular profile differences, researchers have been seeking new targets and therapies, with more specificity and ...
Komoto TT +10 more
europepmc +6 more sources
Protective Role of trans-Chalcone against the Progression from Simple Steatosis to Non-alcoholic Steatohepatitis: Regulation of miR-122, 21, 34a, and 451 [PDF]
Advanced Pharmaceutical Bulletin, 2022 Purpose: Non-alcoholic steatohepatitis (NASH) is an inflammatory disorder and an aggressive form of fatty liver disease. Certain microRNAs, including miR-122, 21, 34a, and 451, are involved in the transition from steatosis to NASH.
Elham Karimi-Sales +3 more
doaj +4 more sources