Mediator and RNA polymerase II clusters associate in transcription-dependent condensates
Science, 2018 Phase separation and gene control Many components of eukaryotic transcription machinery—such as transcription factors and cofactors including BRD4, subunits of the Mediator complex, and RNA polymerase II—contain intrinsically disordered low-complexity ...
W. Cho +6 more
semanticscholar +1 more source
Dynamics of gene expression and the regulatory inference problem
, 2008 From the response to external stimuli to cell division and death, the dynamics of living cells is based on the expression of specific genes at specific times.
+10 more
core +1 more source
Plant Transcription Factors @ uni-potsdam.de [PDF]
, 2007 We present the Plant Transcription Factor Database (PlnTFDB), and the putative complete set of TFs in the algae _Chlamydomonas reinhardtii_, _Ostreococcus tauri_ and the vascular plants _Oryza sativa_ and _Arabidopsis ...
Bernd Mueller-Roeber +3 more
core +2 more sources
Nr4a transcription factors limit CAR T cell function in solid tumors
Nature, 2019 T cells expressing chimeric antigen receptors (CAR T cells) targeting human CD19 (hCD19) have shown clinical efficacy against B cell malignancies1,2.
Joyce Chen +8 more
semanticscholar +1 more source
A novel compartment, the 'subqpical stem' of the aerial hyphae, is the location of a sigN-dependent, developmentally distinct transcription in Streptomyces coelicolor. [PDF]
, 2007 Streptomyces coelicolor has nine SigB-like RNA polymerase sigma factors, several of them implicated in morphological differentiation and/or responses to different stresses. One of the nine, SigN, is the focus of this article.
Bignell D.R. +21 more
core +1 more source
Cis-regulatory module detection using constraint programming [PDF]
, 2010 We propose a method for finding CRMs in a set of co-regulated genes. Each CRM consists of a set of binding sites of transcription factors. We wish to find CRMs involving the same transcription factors in multiple sequences.
Guns, Tias +3 more
core +1 more source
Nucleic Acids Res., 2018 The Animal Transcription Factor DataBase (AnimalTFDB) is a resource aimed to provide the most comprehensive and accurate information for animal transcription factors (TFs) and cofactors.
Hui Hu +5 more
semanticscholar +1 more source
Design, modeling and synthesis of an in vitro transcription rate regulatory circuit [PDF]
, 2008 This paper describes the design, modeling and realization of a synthetic in vitro circuit that aims at regulating the rate of mRNA transcription. Two DNA templates are designed to interact through their transcripts, creating negative feedback loops that ...
Forsberg, Per-Ola +2 more
core +2 more sources
Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution [PDF]
, 2015 Activation-induced deoxycytidine deaminase (AID) generates antibody diversity in B cells by initiating somatic hypermutation (SHM) and class-switch recombination (CSR) during transcription of immunoglobulin variable (IgV) and switch region (IgS) DNA ...
Bertram, JG +7 more
core +1 more source
The Transcription Repressor REST in Adult Neurons: Physiology, Pathology, and Diseases,,
eNeuro, 2015 REST [RE1-silencing transcription factor (also called neuron-restrictive silencer factor)] is known to repress thousands of possible target genes, many of which are neuron specific.
P. Baldelli, J. Meldolesi
semanticscholar +1 more source