Results 1 to 10 of about 3,535,290 (383)

Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress

Scientific Reports, 2021
The emergence of new primate-specific genes is an essential factor in human and primate brain development and functioning. POU2F1/Oct-1 is a transcription regulator in higher eukaryotes which is involved in the regulation of development, differentiation,
Alexander G. Stepchenko, Tatiana N. Portseva, Ivan A. Glukhov, Alina P. Kotnova, Bella M. Lyanova, Sofia G. Georgieva, Elizaveta V. Pankratova   +6 more
doaj   +1 more source

Triple-negative and triple-positive breast cancer cells reciprocally control their growth and migration via the S100A4 pathway

Cell Adhesion & Migration, 2022
The study’s aim was to investigate the S100A4-mediated mechanisms of the regulation of tumor cell proliferation and migration in the human triple-positive breast carcinoma cell line MCF-7 (TPBC) and triple-negative breast carcinoma cell line MDA-MB-231 ...
Elena A. Dukhanina, Tatiana N. Portseva, Alexander S. Dukhanin, Sofia G. Georgieva   +3 more
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TS-Net: OCR Trained to Switch Between Text Transcription Styles [PDF]

ICDAR 2021: Proceedings, Part IV 16 (pp. 478-493), 2021
Users of OCR systems, from different institutions and scientific disciplines, prefer and produce different transcription styles. This presents a problem for training of consistent text recognition neural networks on real-world data. We propose to extend existing text recognition networks with a Transcription Style Block (TSB) which can learn from data ...
arxiv   +1 more source

Dynamic interplay between non-coding enhancer transcription and gene activity in development

Nature Communications, 2023
Non-coding transcription at the intergenic regulatory regions is a prevalent feature of metazoan genomes, but its function remains uncertain. Here the authors show that enhancer function is flexibly tunable through the modulation of hub formation via ...
Kota Hamamoto, Yusuke Umemura, Shiho Makino, Takashi Fukaya   +3 more
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Different functions of PHF10 isoforms – subunits of the PBAF chromatin remodeling complex

Вавиловский журнал генетики и селекции, 2019
Chromatin remodelling multiprotein complexes play an important role in regulation of gene expression in embryogenesis and in the adult organism. Mutations in the subunits of the complexes are often lethal or lead to developmental defects.
A. A. Sheynov, V. V. Tatarskiy, A. M. Azieva, S. G. Georgieva, N. V. Soshnikova   +4 more
doaj   +1 more source

Structural Analysis of (p)ppGpp Reveals Its Versatile Binding Pattern for Diverse Types of Target Proteins

Frontiers in Microbiology, 2020
(p)ppGpp, highly phosphorylated guanosine, are global regulatory nucleotides that modulate several biochemical events in bacterial physiology ranging from core central dogma to various metabolic pathways.
Gajraj Singh Kushwaha, Gajraj Singh Kushwaha, Anupam Patra, Neel Sarovar Bhavesh   +3 more
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A novel chromatin-remodeling complex variant, dcPBAF, is involved in maintaining transcription in differentiated neurons

Frontiers in Cell and Developmental Biology, 2023
The Polybromo-associated BAF (BRG1- or BRM-associated factors) (PBAF) chromatin-remodeling complex is essential for transcription in mammalian cells.
Nataliya V. Soshnikova, Nataliya V. Soshnikova, Nataliya V. Soshnikova, Asya M. Azieva, Asya M. Azieva, Nataliya S. Klimenko, Alvina I. Khamidullina, Alexey V. Feoktistov, Alexey V. Feoktistov, Andrey A. Sheynov, Alexander V. Brechalov, Victor V. Tatarskiy, Sofia G. Georgieva   +12 more
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The sequential phosphorylation of PHF10 subunit of the PBAF chromatin-remodeling complex determines different properties of the PHF10 isoforms

Biology Open, 2020
The mammalian PBAF subfamily of SWI/SNF chromatin remodeling complexes plays a wide role in the regulation of gene expression. PHF10 is a subunit of the signature module of PBAF, responsible for its interaction with chromatin.
Andrey A. Sheynov, Victor V. Tatarskiy, Eugene V. Tatarskiy, Elena N. Nabirochkina, Sofia G. Georgieva, Nataliya V. Soshnikova   +5 more
doaj   +1 more source

N-Terminus Plays a Critical Role for Stabilizing the Filamentous Assembly and the Antifungal Activity of Bg_9562

Microbiology Spectrum, 2022
Bg_9562, a prophage tail-like protein was earlier shown to be required for bacterial mycophagy by Burkholderia gladioli strain NGJ1. The purified protein exhibited broad-spectrum antifungal activity; however, the structural and mechanistic details vis-à ...
Pankaj Kumar Sahoo, Rahul Kumar, Aruna Rani, Sunil Kumar Yadav, Gopaljee Jha, Deepti Jain   +5 more
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Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

eLife, 2016
The myocardin-related transcription factors (MRTF-A and MRTF-B) regulate cytoskeletal genes through their partner transcription factor SRF. The MRTFs bind G-actin, and signal-regulated changes in cellular G-actin concentration control their nuclear ...
Richard Panayiotou, Francesc Miralles, Rafal Pawlowski, Jessica Diring, Helen R Flynn, Mark Skehel, Richard Treisman   +6 more
doaj   +1 more source