Results 1 to 10 of about 4,782,678 (257)
Eukaryotic core promoters and the functional basis of transcription initiation
Nature Reviews Molecular Cell Biology, 2018 Vanja Haberle, Alexander Stark
exaly +2 more sources
Targeting transcription factors in cancer — from undruggable to reality
Nature Reviews Cancer, 2019 John H Bushweller
exaly +2 more sources
Scientific Reports, 2021 The emergence of new primate-specific genes is an essential factor in human and primate brain development and functioning. POU2F1/Oct-1 is a transcription regulator in higher eukaryotes which is involved in the regulation of development, differentiation,
Alexander G. Stepchenko +6 more
doaj +1 more source
Cell Adhesion & Migration, 2022 The study’s aim was to investigate the S100A4-mediated mechanisms of the regulation of tumor cell proliferation and migration in the human triple-positive breast carcinoma cell line MCF-7 (TPBC) and triple-negative breast carcinoma cell line MDA-MB-231 ...
Elena A. Dukhanina +3 more
doaj +1 more source
NRF2, a Transcription Factor for Stress Response and Beyond
International Journal of Molecular Sciences, 2020 Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification.
Feng He, Xiaoli Ru, T. Wen
semanticscholar +1 more source
Dynamic interplay between non-coding enhancer transcription and gene activity in development
Nature Communications, 2023 Non-coding transcription at the intergenic regulatory regions is a prevalent feature of metazoan genomes, but its function remains uncertain. Here the authors show that enhancer function is flexibly tunable through the modulation of hub formation via ...
Kota Hamamoto +3 more
doaj +1 more source
Nucleic Acids Research, 1983 We have developed a procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters.
J. Dignam, R. Lebovitz, R. Roeder
semanticscholar +1 more source
Transcription as a Threat to Genome Integrity [PDF]
, 2016 Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, that constitute the basis for evolution.
Aguilera López, Andrés +1 more
core +1 more source
Characterization of the transcription factor encoding gene, KlADR1: metabolic role in Kluyveromyces lactis and expression in Saccharomyces cerevisiae. [PDF]
, 2016 In Saccharomyces cerevisiae, Adr1 is a zinc-finger transcription factor involved in the transcriptional activation of ADH2. Deletion of KlADR1, its putative ortholog in Kluyveromyces lactis, led to reduced growth in glycerol, oleate and yeast extract ...
Cardarelli, Silvia +6 more
core +1 more source
Landscape of transcription in human cells
Nature, 2012 Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations ...
S. Djebali +84 more
semanticscholar +1 more source