Results 1 to 10 of about 3,372,915 (384)

Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress

open access: yesScientific Reports, 2021
The emergence of new primate-specific genes is an essential factor in human and primate brain development and functioning. POU2F1/Oct-1 is a transcription regulator in higher eukaryotes which is involved in the regulation of development, differentiation,
Alexander G. Stepchenko   +6 more
doaj   +1 more source

Triple-negative and triple-positive breast cancer cells reciprocally control their growth and migration via the S100A4 pathway

open access: yesCell Adhesion & Migration, 2022
The study’s aim was to investigate the S100A4-mediated mechanisms of the regulation of tumor cell proliferation and migration in the human triple-positive breast carcinoma cell line MCF-7 (TPBC) and triple-negative breast carcinoma cell line MDA-MB-231 ...
Elena A. Dukhanina   +3 more
doaj   +1 more source

Dynamic interplay between non-coding enhancer transcription and gene activity in development

open access: yesNature Communications, 2023
Non-coding transcription at the intergenic regulatory regions is a prevalent feature of metazoan genomes, but its function remains uncertain. Here the authors show that enhancer function is flexibly tunable through the modulation of hub formation via ...
Kota Hamamoto   +3 more
doaj   +1 more source

TS-Net: OCR Trained to Switch Between Text Transcription Styles [PDF]

open access: yesICDAR 2021: Proceedings, Part IV 16 (pp. 478-493), 2021
Users of OCR systems, from different institutions and scientific disciplines, prefer and produce different transcription styles. This presents a problem for training of consistent text recognition neural networks on real-world data. We propose to extend existing text recognition networks with a Transcription Style Block (TSB) which can learn from data ...
arxiv   +1 more source

Characterization of the transcription factor encoding gene, KlADR1: metabolic role in Kluyveromyces lactis and expression in Saccharomyces cerevisiae. [PDF]

open access: yes, 2016
In Saccharomyces cerevisiae, Adr1 is a zinc-finger transcription factor involved in the transcriptional activation of ADH2. Deletion of KlADR1, its putative ortholog in Kluyveromyces lactis, led to reduced growth in glycerol, oleate and yeast extract ...
Cardarelli, Silvia   +6 more
core   +1 more source

Transcription as a Threat to Genome Integrity [PDF]

open access: yes, 2016
Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, that constitute the basis for evolution.
Aguilera López, Andrés   +1 more
core   +1 more source

Structural Analysis of (p)ppGpp Reveals Its Versatile Binding Pattern for Diverse Types of Target Proteins

open access: yesFrontiers in Microbiology, 2020
(p)ppGpp, highly phosphorylated guanosine, are global regulatory nucleotides that modulate several biochemical events in bacterial physiology ranging from core central dogma to various metabolic pathways.
Gajraj Singh Kushwaha   +3 more
doaj   +1 more source

A novel chromatin-remodeling complex variant, dcPBAF, is involved in maintaining transcription in differentiated neurons

open access: yesFrontiers in Cell and Developmental Biology, 2023
The Polybromo-associated BAF (BRG1- or BRM-associated factors) (PBAF) chromatin-remodeling complex is essential for transcription in mammalian cells.
Nataliya V. Soshnikova   +12 more
doaj   +1 more source

A compendium of Caenorhabditis elegans regulatory transcription factors: a resource for mapping transcription regulatory networks [PDF]

open access: yes, 2005
Background Transcription regulatory networks are composed of interactions between transcription factors and their target genes. Whereas unicellular networks have been studied extensively, metazoan transcription regulatory networks remain largely ...
Deplancke, B.   +5 more
core   +2 more sources

N-Terminus Plays a Critical Role for Stabilizing the Filamentous Assembly and the Antifungal Activity of Bg_9562

open access: yesMicrobiology Spectrum, 2022
Bg_9562, a prophage tail-like protein was earlier shown to be required for bacterial mycophagy by Burkholderia gladioli strain NGJ1. The purified protein exhibited broad-spectrum antifungal activity; however, the structural and mechanistic details vis-à ...
Pankaj Kumar Sahoo   +5 more
doaj   +1 more source

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