Results 1 to 10 of about 4,936,670 (210)
Targeting transcription factors in cancer — from undruggable to reality
Nature Reviews Cancer, 2019 Mutated or dysregulated transcription factors represent a unique class of drug targets that mediate aberrant gene expression, including blockade of differentiation and cell death gene expression programmes, hallmark properties of cancers.
John H Bushweller
exaly +2 more sources
Scientific Reports, 2021 The emergence of new primate-specific genes is an essential factor in human and primate brain development and functioning. POU2F1/Oct-1 is a transcription regulator in higher eukaryotes which is involved in the regulation of development, differentiation,
Alexander G. Stepchenko +6 more
doaj +1 more source
Cell Adhesion & Migration, 2022 The study’s aim was to investigate the S100A4-mediated mechanisms of the regulation of tumor cell proliferation and migration in the human triple-positive breast carcinoma cell line MCF-7 (TPBC) and triple-negative breast carcinoma cell line MDA-MB-231 ...
Elena A. Dukhanina +3 more
doaj +1 more source
Protocol for analysis of G2/M DNA synthesis in human cells
STAR Protocols, 2021 Summary: G2/M DNA synthesis (G-MiDS) can be observed in one in five G2/M cells in unperturbed conditions by immunofluorescence microscopy. However, little is known of the genomic sites undergoing G-MiDS.
Jianming Wang, Marco Saponaro
doaj +1 more source
Dynamic interplay between non-coding enhancer transcription and gene activity in development
Nature Communications, 2023 Non-coding transcription at the intergenic regulatory regions is a prevalent feature of metazoan genomes, but its function remains uncertain. Here the authors show that enhancer function is flexibly tunable through the modulation of hub formation via ...
Kota Hamamoto +3 more
doaj +1 more source
Characterization of the transcription factor encoding gene, KlADR1: metabolic role in Kluyveromyces lactis and expression in Saccharomyces cerevisiae. [PDF]
, 2016 In Saccharomyces cerevisiae, Adr1 is a zinc-finger transcription factor involved in the transcriptional activation of ADH2. Deletion of KlADR1, its putative ortholog in Kluyveromyces lactis, led to reduced growth in glycerol, oleate and yeast extract ...
Cardarelli, Silvia +6 more
core +1 more source
Molecules and Cells, 2010 Summary Genome-scale studies have revealed extensive, cell type-specific co-localization of transcription factors, but the mechanisms underlying this phenomenon remain poorly understood.
S. Heinz +9 more
semanticscholar +1 more source
iScience, 2023 Summary: Motility in Pseudomonas aeruginosa is mediated through a single, polar flagellum, which is essential for virulence, colonization, and biofilm formation.
Pankaj Kumar Sahoo, Sheenu, Deepti Jain
doaj +1 more source
In vivo delivery of transcription factors with multifunctional oligonucleotides. [PDF]
, 2015 Therapeutics based on transcription factors have the potential to revolutionize medicine but have had limited clinical success as a consequence of delivery problems. The delivery of transcription factors is challenging because it requires the development
Aran, Kiana +9 more
core +3 more sources
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.
Cell, 1999 Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/ threonine kinase Akt, which then phosphorylates and inactivates components of the apoptotic machinery, including BAD and Caspase 9.
A. Brunet +9 more
semanticscholar +1 more source