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The emergence of new primate-specific genes is an essential factor in human and primate brain development and functioning. POU2F1/Oct-1 is a transcription regulator in higher eukaryotes which is involved in the regulation of development, differentiation,
Alexander G. Stepchenko+6 more
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The study’s aim was to investigate the S100A4-mediated mechanisms of the regulation of tumor cell proliferation and migration in the human triple-positive breast carcinoma cell line MCF-7 (TPBC) and triple-negative breast carcinoma cell line MDA-MB-231 ...
Elena A. Dukhanina+3 more
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Dynamic interplay between non-coding enhancer transcription and gene activity in development
Non-coding transcription at the intergenic regulatory regions is a prevalent feature of metazoan genomes, but its function remains uncertain. Here the authors show that enhancer function is flexibly tunable through the modulation of hub formation via ...
Kota Hamamoto+3 more
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TS-Net: OCR Trained to Switch Between Text Transcription Styles [PDF]
Users of OCR systems, from different institutions and scientific disciplines, prefer and produce different transcription styles. This presents a problem for training of consistent text recognition neural networks on real-world data. We propose to extend existing text recognition networks with a Transcription Style Block (TSB) which can learn from data ...
arxiv +1 more source
Characterization of the transcription factor encoding gene, KlADR1: metabolic role in Kluyveromyces lactis and expression in Saccharomyces cerevisiae. [PDF]
In Saccharomyces cerevisiae, Adr1 is a zinc-finger transcription factor involved in the transcriptional activation of ADH2. Deletion of KlADR1, its putative ortholog in Kluyveromyces lactis, led to reduced growth in glycerol, oleate and yeast extract ...
Cardarelli, Silvia+6 more
core +1 more source
Transcription as a Threat to Genome Integrity [PDF]
Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, that constitute the basis for evolution.
Aguilera López, Andrés+1 more
core +1 more source
(p)ppGpp, highly phosphorylated guanosine, are global regulatory nucleotides that modulate several biochemical events in bacterial physiology ranging from core central dogma to various metabolic pathways.
Gajraj Singh Kushwaha+3 more
doaj +1 more source
The Polybromo-associated BAF (BRG1- or BRM-associated factors) (PBAF) chromatin-remodeling complex is essential for transcription in mammalian cells.
Nataliya V. Soshnikova+12 more
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A compendium of Caenorhabditis elegans regulatory transcription factors: a resource for mapping transcription regulatory networks [PDF]
Background Transcription regulatory networks are composed of interactions between transcription factors and their target genes. Whereas unicellular networks have been studied extensively, metazoan transcription regulatory networks remain largely ...
Deplancke, B.+5 more
core +2 more sources
Bg_9562, a prophage tail-like protein was earlier shown to be required for bacterial mycophagy by Burkholderia gladioli strain NGJ1. The purified protein exhibited broad-spectrum antifungal activity; however, the structural and mechanistic details vis-à ...
Pankaj Kumar Sahoo+5 more
doaj +1 more source