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Metal‐responsive transcription factor‐1 (MTF‐1) is essential for embryonic liver development and heavy metal detoxification in the adult liver

The FASEB Journal, 2004
ABSTRACT Metal‐responsive transcription factor‐1 (MTF‐1) activates the transcription of metallothionein genes and other target genes in response to heavy metal load and other stresses such as hypoxia and oxidative stress. It also has an essential function during embryo‐genesis: targeted disruption of
Wang, Ying +11 more
openaire +3 more sources

Gawky modulates MTF-1-mediated transcription activation and metal discrimination

Nucleic Acids Research, 2021
Zhengguo Li, Ge Shan, Chuan Huang
exaly

A conserved cysteine cluster, essential for transcriptional activity, mediates homodimerization of human metal-responsive transcription factor-1 (MTF-1)

Biochimica Et Biophysica Acta - Molecular Cell Research, 2012
Viola GÜNTHER, Oleg Georgiev, Walter Schaffner +2 more
exaly

Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis

EMBO Journal, 2003
Dieter Egli, Ernst Hafen, Oleg Georgiev +2 more
exaly

Superinduction of metallothionein I by inhibition of protein synthesis: Role of a labile repressor in MTF-1 mediated gene transcription

Journal of Biochemical and Molecular Toxicology, 2006
Yongyi Bi
exaly

The taste of heavy metals: Gene regulation by MTF-1

Biochimica Et Biophysica Acta - Molecular Cell Research, 2012
Viola GÜNTHER, Walter Schaffner
exaly

Efficient metal-specific transcription activation by Drosophila MTF-1 requires conserved cysteine residues in the carboxy-terminal domain

Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2012
Michael T Marr
exaly