Results 1 to 10 of about 35,051 (207)

Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes

Nature Communications, 2016
Rela is a transcription factor shown to have seemingly contradictory roles in anabolism and catabolism of cartilage. Here the authors find that Rela prevents chondrocyte apoptosis and that homozygous knockout causes accelerated osteoarthritis in adults ...
Hiroshi Kobayashi, Song Ho Chang, Daisuke Mori, Shozo Itoh, Makoto Hirata, Yoko Hosaka, Yuki Taniguchi, Keita Okada, Yoshifumi Mori, Fumiko Yano, Ung-il Chung, Haruhiko Akiyama, Hiroshi Kawaguchi, Sakae Tanaka, Taku Saito   +14 more
doaj   +2 more sources

Aging-related signature stratifies LUAD prognosis and uncovers senescence-induced chemoresistance via NF-κB/RELA activation [PDF]

Respiratory Research
Background Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer and a leading cause of cancer-related mortality worldwide. Aging has emerged as a significant risk factor for LUAD, with evidence suggesting that age-associated biological ...
Chengyue Zhu, Ying Dong, Yue Dong, Xinyu Shang, Jintong Dong, Tingting Ge, Zhijun Jie, Jia Li, Yi Zang, Jindong Shi   +9 more
doaj   +2 more sources

Quantitative Structure-activity Relationship-based Neural Network Model in Screening Potential Inhibitors from Brown Algae against RelA in Oral Squamous Cell Carcinoma [PDF]

International Dental Journal
Introduction and Aim: Oral squamous cell carcinomas (OSCCs) are one of the most frequently diagnosed head and neck cancers with a poor prognosis despite the advancements in diagnostic techniques and treatment strategies. The progression of OSCC is driven
Abdullah Alqarni, Jagadish Hosmani, Saeed Alassiri, Ali Mosfer A. Alqahtani, Hassan Ahmed Assiri, Thabet AlHousami, Hattan Zaki, Shankargouda Patil   +7 more
doaj   +2 more sources

RelA Inhibits Embryonic Myogenesis by Coordinately Regulating a Novel Distal Enhancer of Myogenin [PDF]

Advanced Science
Skeletal muscle is crucial for lifelong metabolic health, with its development initiating during embryogenesis and guiding later growth. Single‐cell RNA sequencing of E13.5 mouse embryos suggests that maternal obesity impairs embryonic myogenesis ...
Md Nazmul Hossain, Yao Gao, Sharmeen Islam, Li‐Wei Chen, Xinrui Li, Zhongyun Kou, Nathan C Law, Jeanene Marie deAvila, Mei‐Jun Zhu, Min Du   +9 more
doaj   +2 more sources

SOX4 and RELA Function as Transcriptional Partners to Regulate the Expression of TNF- Responsive Genes in Fibroblast-Like Synoviocytes

Frontiers in Immunology, 2022
SOX4 belongs to the group C of the SOX transcription factor family. It is a critical mediator of tumor necrosis factor alpha (TNF)-induced transformation of fibroblast-like s-ynoviocytes (FLS) in arthritis.
Kyle Jones, Kyle Jones, Sergio Ramirez-Perez, Sergio Ramirez-Perez, Sean Niu, Sean Niu, Umesh Gangishetti, Umesh Gangishetti, Hicham Drissi, Hicham Drissi, Hicham Drissi, Pallavi Bhattaram, Pallavi Bhattaram   +12 more
doaj   +1 more source

RELA is required for CD271 expression and stem-like characteristics in hypopharyngeal cancer

Scientific Reports, 2022
CD271 (also referred to as nerve growth factor receptor or p75NTR) is expressed on cancer stem cells in hypopharyngeal cancer (HPC) and regulates cell proliferation.
Akira Nakazato, Mai Mochizuki, Rie Shibuya-Takahashi, Haruna Fujimori, Keitaro Fujii, Satoshi Saijoh, Shinkichi Morita, Tomoko Yamazaki, Takayuki Imai, Ikuro Sato, Kennichi Satoh, Kazunori Yamaguchi, Kazuo Sugamura, Jun Yasuda, Kazuto Matsuura, Hideo Shojaku, Yukinori Asada, Keiichi Tamai   +17 more
doaj   +1 more source

C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation

Acta Neuropathologica Communications, 2021
Recurrent C11orf95-RELA fusions (RELA FUS ) are the hallmark of supratentorial ependymomas. The presence of RELA as the fusion partner indicates a close association of aberrant NF-κB activity with tumorigenesis.
Tatsuya Ozawa, Syuzo Kaneko, Frank Szulzewsky, Zhiwei Qiao, Mutsumi Takadera, Yoshitaka Narita, Tadashi Kondo, Eric C. Holland, Ryuji Hamamoto, Koichi Ichimura   +9 more
doaj   +1 more source

Identification of super-enhancer-associated transcription factors regulating glucose metabolism in poorly differentiated thyroid carcinoma

Genetics and Molecular Biology, 2022
This study aimed to uncover transcription factors that regulate super-enhancers involved in glucose metabolism reprogramming in poorly differentiated thyroid carcinoma (PDTC).
Kun Liu, Yongrui Du, Hui Li, Xuexia Lin
doaj   +1 more source

Ependymoma associated protein Zfta is expressed in immature ependymal cells but is not essential for ependymal development in mice

Scientific Reports, 2022
The fusion protein of uncharacterised zinc finger translocation associated (ZFTA) and effector transcription factor of tumorigenic NF-κB signalling, RELA (ZFTA-RELA), is expressed in more than two-thirds of supratentorial ependymoma (ST-EPN-RELA), but ...
Vicente Herranz-Pérez, Jin Nakatani, Masaki Ishii, Toshiaki Katada, Jose Manuel García-Verdugo, Shinya Ohata   +5 more
doaj   +1 more source

Analysis of the RelA:CBP/p300 interaction reveals its involvement in NF-κB-driven transcription. [PDF]

PLoS Biology, 2013
NF-κB plays a vital role in cellular immune and inflammatory response, survival, and proliferation by regulating the transcription of various genes involved in these processes.
Sulakshana P Mukherjee, Marcelo Behar, Harry A Birnbaum, Alexander Hoffmann, Peter E Wright, Gourisankar Ghosh   +5 more
doaj   +1 more source