Results 11 to 20 of about 35,051 (207)

Forkhead transcription factor FOXP3 upregulates CD25 expression through cooperation with RelA/NF-κB.

PLoS ONE, 2012
Considerable evidence supports the prediction that CD25 is directly regulated by the forkhead transcription factor FOXP3. However, given that CD25 is normally upregulated in activated T cells, regardless of whether they express FOXP3, this issue has ...
Cristina Camperio, Silvana Caristi, Giorgia Fanelli, Marzia Soligo, Paola Del Porto, Enza Piccolella   +5 more
doaj   +4 more sources

The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability [PDF]

Frontiers in Immunology, 2019
Regulatory T cells (Tregs) play a major role in immune homeostasis and in the prevention of autoimmune diseases. It has been shown that c-Rel is critical in Treg thymic differentiation, but little is known on the role of NF-κB on mature Treg biology.
Emilie Ronin, Martina Lubrano di Ricco, Romain Vallion, Jordane Divoux, Ho-Keun Kwon, Sylvie Grégoire, Davi Collares, Angéline Rouers, Véronique Baud, Christophe Benoist, Benoit L. Salomon   +10 more
doaj   +4 more sources

The proximity-based protein interactome and regulatory logics of the transcription factor p65 NF-κB/RELA

EMBO Reports
The protein interactome of p65/RELA, the most active subunit of the transcription factor (TF) NF-κB, has not been previously determined in living cells.
Lisa Leib, Jana Juli, Liane Jurida, Christin Mayr-Buro, Jasmin Priester, Hendrik Weiser, Stefanie Wirth, Simon Hanel, Daniel Heylmann, Axel Weber, M Lienhard Schmitz, Argyris Papantonis, Marek Bartkuhn, Jochen Wilhelm, Uwe Linne, Johanna Meier-Soelch, Michael Kracht   +16 more
doaj   +4 more sources

Dynamics of REL, RELA and IRF1 transcription factor expression in U937 macrophages after dioxin exposure

Вавиловский журнал генетики и селекции, 2017
The aryl hydrocarbon receptor (AhR), a ligand- activated transcription factor, participates in a wide range of critical cellular events in response to endogenous signals or xenobiotic chemicals. 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) is one of the
E. V. Kashina, D. Y. Oshchepkov, E. V. Antontseva, M. Y. Shamanina, D. P. Furman, V. A. Mordvinov   +5 more
doaj   +3 more sources

The NF-κB RelA transcription factor is not required for CD8+ T-cell function in acute viral infection and cancer

Frontiers in Immunology
CD8+ T cells are critical mediators of pathogen clearance and anti-tumor immunity. Although signaling pathways leading to the activation of NF-κB transcription factors have crucial functions in the regulation of immune responses, the CD8+ T cell ...
Allison Voisin, Maud Plaschka, Maud Plaschka, Marlène Perrin-Niquet, Julie Twardowski, Insaf Boutemine, Baptiste Eluard, Guilhem Lalle, Pierre Stéphan, Khaled Bouherrou, Laurie Tonon, Laurie Tonon, Roxane Pommier, Roxane Pommier, Anthony Ferrari, Anthony Ferrari, Ulf Klein, Mélanie Wencker, Véronique Baud, Philippe A. Cassier, Philippe A. Cassier, Yenkel Grinberg-Bleyer   +21 more
doaj   +6 more sources

Yangonin Blocks Tumor Necrosis Factor-α–Induced Nuclear Factor-κB–Dependent Transcription by Inhibiting the Transactivation Potential of the RelA/p65 Subunit

Journal of Pharmacological Sciences, 2012
The nuclear factor-κB (NF-κB) transcription factors control many physiological processes including inflammation, immunity, and apoptosis. In our search for NF-κB inhibitors from natural resources, we identified yangonin from Piper methysticum as an ...
Juan Ma, He Liang, Hong Ri Jin, Nguyen Tien Dat, Shan Yu Zhang, Ying Zi Jiang, Ji Xing Nan, Donghao Li, Xue Wu, Jung Joon Lee, Xuejun Jin   +10 more
doaj   +4 more sources

Modulation of Gene Expression Regulated by the Transcription Factor NF-κB/RelA [PDF]

Journal of Biological Chemistry, 2014
Modulators (Ms) are proteins that modify the activity of transcription factors (TFs) and influence expression of their target genes (TGs). To discover modulators of NF-κB/RelA, we first identified 365 NF-κB/RelA-binding proteins using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Xueling, Li, Yingxin, Zhao, Bing, Tian, Mohammad, Jamaluddin, Abhishek, Mitra, Jun, Yang, Maga, Rowicka, Allan R, Brasier, Andrzej, Kudlicki   +8 more
openaire   +2 more sources

Inferring Genome-Wide Functional Modulatory Network: A Case Study on NF-κB/RelA Transcription Factor [PDF]

Journal of Computational Biology, 2015
How different pathways lead to the activation of a specific transcription factor (TF) with specific effects is not fully understood. We model context-specific transcriptional regulation as a modulatory network: triplets composed of a TF, target gene, and modulator. Modulators usually affect the activity of a specific TF at the posttranscriptional level
Xueling, Li, Min, Zhu, Allan R, Brasier, Andrzej S, Kudlicki   +3 more
openaire   +2 more sources

EPEN-05. TRANSCRIPTIONAL FACTOR-DIRECTED EPIGENETIC REGULATION IN CANCER NEUROSCIENCE OF ZFTA-RELA EPENDYMOMA

Neuro-Oncology, 2023
Abstract ZFTA-RELA (ZRFUS) ependymoma is a pediatric brain tumor with dismal 10-year progression free survival rates. Prior studies revealed low somatic mutation load in pediatric ependymoma compared to adult glioma, suggesting that developmental mechanisms play a key role during disease development.
Chen, Hsiao-Chi, McDonald, Malcolm, Varadharajan, Srinidhi, Sardar, Debosmita, Mack, Stephen C, Deneen, Benjamin   +5 more
openaire   +1 more source

NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB [PDF]

Cancers, 2019
Regulation of Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)/Rel transcription factors (TFs) is extremely cell-type-specific owing to their ability to act disparately in the context of cellular homeostasis driven by cellular fate and the microenvironment.
Derya Kabacaoglu, Dietrich A. Ruess, Jiaoyu Ai, Hana Algül   +3 more
openaire   +4 more sources