Results 221 to 230 of about 36,830 (233)

Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissue.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2002
Activation of transcription factor nuclear factor-kappaB (NF-kappaB) has been shown to play a role in cell proliferation, apoptosis, cytokine production, and oncogenesis. The purpose of this study was to determine whether NF-kappaB is constitutively activated in human gastric carcinoma tissues and, if so, to determine any correlation between NF-kappaB ...
N, Sasaki, T, Morisaki, K, Hashizume, T, Yao, M, Tsuneyoshi, H, Noshiro, K, Nakamura, T, Yamanaka, A, Uchiyama, M, Tanaka, M, Katano   +10 more
openaire   +1 more source

IL-8 INDUCTION BY RESPIRATORY SYNCYTIAL VIRUS (RSV) INFECTION IS MEDIATED BY RelA (NF-kB) TRANSCRIPTION FACTOR. • 49

Pediatric Research, 1996
In previous studies, we have shown that RSV replication in A549 cells (a type II alveolar epithelial cell line) induces a dose- and time-dependent release of IL-8. We have subsequently investigated the mechanisms of IL-8 induction. By RT-PCR, the IL-8 mRNA, barely detectable in control cells, was strongly induced by RSV infection; the IL-8 mRNA ...
Roberto Garofalo, Mona Sabry, Kangmin Yu, Antonella Casola, Tadahito Saito, Mohammad Jamaluddin, Pearay L Ogra, Allan R Brasier   +7 more
openaire   +1 more source

[Transcription factor NF-kappa B/RelA are constitutively activated and localized in the cell nuclei of E1A + cHa-Ras transformants].

Tsitologiia, 1999
DNA binding activity and intracellular distribution of transcription factor NF-kappa B in primary embryo fibroblast (REF) cells transformed by the complementing oncogenes E1A plus cHa-ras have been studied. By means of a gel retardation assay with a regulatory element kappa B, we showed that DNA binding activity of NF-kappa B increased upon ...
Z A, Darieva, V A, Pospelov, T V, Pospelova   +2 more
openaire   +2 more sources

An intrinsically disordered transcription activation domain increases the DNA binding affinity and reduces the specificity of NFκB p50/RelA

Journal of Biological Chemistry, 2022
Hannah E R Baughman, Dominic Narang, Peter G Wolynes   +2 more
exaly  

The proximity-based protein interaction landscape of the transcription factor p65 NF-κB / RELA and its gene-regulatory logics

Abstract The protein interactome of p65 / RELA, the most active subunit of the transcription factor (TF) NF-κB, has not been previously determined in living cells. Using p65-miniTurbo fusion proteins, we identified by biotin tagging > 350 RELA interactors from untreated and IL-1α-stimulated cells, including many TFs (47 % of all ...
Lisa Leib, Jana Juli, Liane Jurida, Johanna Meier-Soelch, Christin Mayr-Buro, M. Lienhard Schmitz, Daniel Heylmann, Axel Weber, Argyris Papantonis, Marek Bartkuhn, Jochen Wilhelm, Uwe Linne, Michael Kracht   +12 more
openaire   +1 more source

Dynamic phosphorylation of RelA on Ser42 and Ser45 in response to TNFα stimulation regulates DNA binding and transcription

Open Biology, 2016
Francesco Lanucara, Jelena Mann, Tom P Monie   +2 more
exaly  

The DEAD‐box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB‐mediated transcription

Journal of Cellular Biochemistry, 2009
Xiaoyun Wu, Yongxin Mu, Deyin Guo
exaly  

Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination

Oncogene, 2011
Michael Kracht, M Lienhard Schmitz, Ezra Burstein   +2 more
exaly  

Modification of RelA by O - linked N -acetylglucosamine links glucose metabolism to NF-κB acetylation and transcription

Proceedings of the National Academy of Sciences of the United States of America, 2012
Gerald W Hart, David R Jones, Marty W Mayo   +2 more
exaly  

Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB

EMBO Journal, 2002
Lin-Feng Chen, Warner C Greene
exaly