Results 211 to 220 of about 36,830 (233)

Transcription factor RELA promotes hepatocellular carcinoma progression by promoting the transcription of m6A modulator METTL3

Pathology Research and Practice
To explore the biological function of RELA proto-oncogene, NF-kB subunit (RELA) in hepatocellular carcinoma (HCC) progression, and its potential regulatory effects on the regulators of m6A modification.GEPIA, UALCAN and Human Protein Atlas databases were applied to analyze the expression characteristics of RELA in HCC tissues and non-cancer liver ...
Weixing Wang, Yongbin Zheng, Wenhong Deng   +2 more
exaly   +3 more sources

Optogenetic control of RelA reveals effect of transcription factor dynamics on downstream gene expression

2022
Abstract Many transcription factors (TFs) translocate to the nucleus with varied dynamic patterns in response to different inputs. A notable example of such behavior is RelA, a subunit of NF-κB, which translocates to the nucleus with either pulsed or sustained dynamics, depending on the stimulus.
Lindsey C. Osimiri, Alain R. Bonny, Seesha R. Takagishi, Stefanie Luecke, Nina Riehs, Alexander Hoffmann, Hana El-Samad   +6 more
openaire   +1 more source

Involvement of Egr-1/RelA Synergy in Distinguishing T Cell Activation from Tumor Necrosis Factor-α–induced NF-κB1 Transcription

Journal of Experimental Medicine, 1997
NF-κB is an important transcription factor required for T cell proliferation and other immunological functions. The NF-κB1 gene encodes a 105-kD protein that is the precursor of the p50 component of NF-κB. Previously, we and others have demonstrated that
Patricia C Cogswell, Marty W Mayo, Albert S Baldwin   +2 more
exaly   +3 more sources

Expression of constitutively active Nuclear-κB RelA transcription factor in blasts of acute myeloid leukemia

Human Pathology, 2004
The nuclear transcription factor NF-kappa B regulates cell survival, proliferation, and differentiation. Little is known about NF-kappa B in myeloid malignancies. In this report, we assessed NF-kappa B in a group of myeloid neoplasms by using an electrophoretic mobility shift assay (EMSA) and immunofluorescence methods in freshly isolated leukemia ...
Carlos E, Bueso-Ramos, Frederico C, Rocha, Shishir, Shishodia, L Jeffrey, Medeiros, Hagop M, Kantarjian, Saroj, Vadhan-Raj, Zeev, Estrov, Terry L, Smith, Martin H, Nguyen, Bharat B, Aggarwal   +9 more
openaire   +2 more sources

The DEAD‐box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB‐mediated transcription

Journal of Cellular Biochemistry, 2008
AbstractDEAD‐box RNA helicases constitute the largest family of RNA helicases and are involved in many aspects of RNA metabolism. In this study, we identified RelA (p65), a subunit of nuclear factor‐kappaB (NF‐κB), as a cellular co‐factor of DEAD‐box RNA helicase DDX1, through mammalian two hybrid system and co‐immunoprecipitation assay.
Musarat, Ishaq, Li, Ma, Xiaoyun, Wu, Yongxin, Mu, Ji'an, Pan, Jiajie, Hu, Tao, Hu, Qiong, Fu, Deyin, Guo   +8 more
openaire   +2 more sources

Expression dynamics of the REL, RELA, and IRF1 transcription factors in U937 macrophages after dioxin exposure

Russian Journal of Genetics: Applied Research, 2017
The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, is involved in a wide range of critical cellular events in response to endogenous signals or xenobiotics. 2,3,7,8-Tetrachlorodibenzo-para-dioxin (TCDD) is one of the AhR ligands with the maximum affinity for AhR. TCDD is the most toxic among the dioxin xenobiotics and induces
E. V. Kashina, D. Y. Oshchepkov, E. V. Antontseva, M. Y. Shamanina, D. P. Furman, V. A. Mordvinov   +5 more
openaire   +1 more source

RelA/NF-kappaB transcription factor associates with alpha-actinin-4.

Experimental cell research, 2008
The NF-kappaB/RelA family of transcription factors regulates inducible transcription of a large number of genes in response to diverse stimuli. Little is known, however, about the location of NF-kappaB in the cytoplasm and the transport mechanism to the nucleus. We found that NF-kappaB is associated with the actin-binding protein alpha-actinin-4.
Vladimir N, Babakov, Olga A, Petukhova, Lidia V, Turoverova, Irina V, Kropacheva, Dmitri G, Tentler, Anastasia V, Bolshakova, Ekaterina P, Podolskaya, Karl-Eric, Magnusson, George P, Pinaev   +8 more
openaire   +1 more source

p53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300.

Cancer research, 1998
The p53 tumor suppressor gene plays an instrumental role in transcriptional regulation of target genes involved in cellular stress responses. p53-dependent transactivation and transrepression require its interaction with p300/CBP, a coactivator that also interacts with the RelA subunit of nuclear factor-kappaB.
Ravi R., Mookerjee B., van Hensbergen Y., Bedi G. C., Giordano A., El-Deiry W. S., Fuchs E. J., Bedi A.   +7 more
openaire   +2 more sources

Lipopolysaccharide activates ERK–PARP-1–RelA pathway and promotes nuclear factor–κB transcription in murine macrophages

Human Immunology, 2012
Poly(ADP-ribosyl)ation, like acetylation, methylation and phosphorylation, is one of the essential post-translational protein modifications. Poly(ADP-ribose) polymerase 1 (PARP-1), the best characterized member of the PARP family, catalyzes PAR formation, and has been implemented in the in vivo and in vitro inflammatory disease models.
Linlin, Liu, Yueshuang, Ke, Xue, Jiang, Fen, He, Lang, Pan, Li, Xu, Xianlu, Zeng, Xueqing, Ba   +7 more
openaire   +2 more sources

The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells.

Clinical cancer research : an official journal of the American Association for Cancer Research, 1999
Pancreatic adenocarcinoma is a leading cause of adult cancer mortality in the United States. Recent studies have revealed that point mutation of the K-ras oncogene is a common event in pancreatic cancer, and oncogenesis mediated by Ras may also involve activation of Rel/nuclear factor (NF)-kappa B transcription factors. Furthermore, the c-rel member of
W, Wang, J L, Abbruzzese, D B, Evans, L, Larry, K R, Cleary, P J, Chiao   +5 more
openaire   +1 more source