Results 21 to 30 of about 35,051 (207)
The FASEB Journal, 2021 The transcriptional co‐activator YAP1 (yes‐associated protein 1) is a critical nuclear effector of the Hippo pathway. The Hippo pathway regulates cell growth, cell motility, cell migration, and carcinogenesis, but poorly defined mechanism. We investigated biochemical and functional interactions between YAP1 and the nuclear factor (NF)‐kappa B/RELA ...
Bekir Cinar +5 more
openaire +1 more source
c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis
Hepatology, EarlyView., 2022 In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie +17 more
wiley +1 more source
NF-κB repression by PIAS3 mediated RelA SUMOylation. [PDF]
PLoS ONE, 2012 Negative regulation of the NF-κB transcription factor is essential for tissue homeostasis in response to stress and inflammation. NF-κB activity is regulated by a variety of biochemical mechanisms including phosphorylation, acetylation, and ...
Yuangang Liu +3 more
doaj +1 more source
Effects of Human RelA Transgene on Murine Macrophage Inflammatory Responses
Biomedicines, 2022 The NFκB transcription factors are major regulators of innate immune responses, and NFκB signal pathway dysregulation is linked to inflammatory disease. Here, we utilised bone marrow-derived macrophages from the p65-DsRedxp/IκBα-eGFP transgenic strain to
Stamatia Papoutsopoulou +12 more
doaj +1 more source
Heliyon, 2018 NF-κB and TonEBP belong to the Rel-superfamily of transcription factors. Several specific stimuli, including hypertonicity which is a key factor for renal physiology, are able to activate them. It has been reported that, after hypertonic challenge, NF-κB
Cecilia I. Casali +2 more
doaj +1 more source
NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1.
PLoS Genetics, 2021 In mammals, the circadian clock coordinates cell physiological processes including inflammation. Recent studies suggested a crosstalk between these two pathways. However, the mechanism of how inflammation affects the clock is not well understood.
Yang Shen +11 more
doaj +1 more source
The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects [PDF]
Proceedings of the National Academy of Sciences, 1999 Individual Rel/NF-κB transcription factors, although dispensable for the development and maturation of most hemopoietic cells, are critical regulators of normal immune function. Redundancy among these proteins prompted us to examine the role of Rel and RelA in hemopoiesis by using mice that lack both subunits.
Grossmann, Mathis +5 more
openaire +3 more sources
Cell Reports, 2017 After exiting the thymus, Foxp3+ regulatory T (Treg) cells undergo further differentiation in the periphery, resulting in the generation of mature, fully suppressive effector (e)Treg cells in a process dependent on TCR signaling and the transcription ...
Ajithkumar Vasanthakumar +20 more
doaj +1 more source
World Journal of Gastroenterology, 2004 Activation of transcription factor nuclear factor-kappaB (NF-kappaB) has been shown to play a role in cell proliferation, apoptosis, cytokine production, and oncogenesis. The purpose of this study was to determine whether NF-kappaB was constitutively activated in human colorectal tumor tissues and, if so, to determine the role of NF-kappaB in ...
Liang-Liang, Yu +5 more
openaire +2 more sources
Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation.
PLoS Biology, 2018 Transcription factor nuclear factor kappa B (NF-κB) regulates cellular responses to environmental cues. Many stimuli induce NF-κB transiently, making time-dependent transcriptional outputs a fundamental feature of NF-κB activation.
Mingming Zhao +7 more
doaj +1 more source