Results 31 to 40 of about 35,051 (207)

BRCA1 Augments Transcription by the NF-κB Transcription Factor by Binding to the Rel Domain of the p65/RelA Subunit [PDF]

Journal of Biological Chemistry, 2003
BRCA1 is a tumor suppressor gene mutated in cases of hereditary breast and ovarian cancer. BRCA1 protein is involved in apoptosis and growth/tumor suppression. In this study, we present evidence that p65/RelA, one of the two subunits of the transcription factor NF-kappaB, binds to the BRCA1 protein.
Miriam, Benezra, Nathalie, Chevallier, Debra J, Morrison, Timothy K, MacLachlan, Wafik S, El-Deiry, Jonathan D, Licht   +5 more
openaire   +2 more sources

An Expanded Interplay Network between NF-κB p65 (RelA) and E2F1 Transcription Factors: Roles in Physiology and Pathology

Cancers, 2022
Transcription Factors (TFs) are the main regulators of gene expression, controlling among others cell homeostasis, identity, and fate. TFs may either act synergistically or antagonistically on nearby regulatory elements and their interplay may activate or repress gene expression. The family of NF-κB TFs is among the most important TFs in the regulation
Spyros Foutadakis, Eugenia Roupakia, Panagiotis Liakopoulos, Petros Kolovos, Evangelos Kolettas   +4 more
openaire   +2 more sources

Immortalized embryonic mouse fibroblasts lacking the RelA subunit of transcription factor NF-κB have a malignantly transformed phenotype [PDF]

Oncogene, 2002
The RelA transcription factor is part of dimeric complexes, most commonly either p50-RelA (NF-kappaB) heterodimers or RelA homodimers, that control a variety of cellular processes. Immortalized embryonic fibroblasts established from rela knockout mice have previously been shown to be more sensitive to apoptosis induced by tumor necrosis factor (TNF ...
Maria-Emily R, Gapuzan, Pavel V, Yufit, Thomas D, Gilmore   +2 more
openaire   +6 more sources

Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1

Nature Communications, 2020
The nuclear factors κB (NF-κB) is a transcription factor involved in immune functions, inflammation, and cancer. Here, the authors show that the NF-κB factor RELA regulates splicing of target genes by recruiting DDX17 on chromatin upon expression of the ...
Lamya Ben Ameur, Paul Marie, Morgan Thenoz, Guillaume Giraud, Emmanuel Combe, Jean-Baptiste Claude, Sebastien Lemaire, Nicolas Fontrodona, Hélène Polveche, Marine Bastien, Antoine Gessain, Eric Wattel, Cyril F. Bourgeois, Didier Auboeuf, Franck Mortreux   +14 more
doaj   +1 more source

Recruitment of RelB to the Csf2 Promoter Enhances RelA-mediated Transcription of Granulocyte-Macrophage Colony-stimulating Factor [PDF]

Journal of Biological Chemistry, 2011
Tumor necrosis factor (TNF) induces expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) but lymphotoxin β (LTβ) does not. Here we report that priming of cells with agonistic LTβ receptor antibody synergistically enhanced TNF-induced GM-CSF expression.
Carl Y, Sasaki, Paritosh, Ghosh, Dan L, Longo   +2 more
openaire   +2 more sources

Aggressive Supratentorial Ependymoma, Fusion-Positive with Extracranial Metastasis: A Case Report [PDF]

Journal of Pathology and Translational Medicine, 2017
Ependymoma is the third most common pediatric primary brain tumor. Ependymomas are categorized according to their locations and genetic abnormalities, and these two parameters are important prognostic factors for patient outcome.
Seong-Ik Kim, Yoojin Lee, Seung Ki Kim, Hyoung Jin Kang, Sung-Hye Park   +4 more
doaj   +1 more source

DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor κB are not correlated [PDF]

Journal of Biological Chemistry, 2017
The nuclear factor κB (NF-κB) transcription factor family regulates genes involved in cell proliferation and inflammation. The promoters of these genes often contain NF-κB-binding sites (κB sites) arranged in tandem. How NF-κB activates transcription through these multiple sites is incompletely understood.
Maria Carmen Mulero, De-Bin Huang, H. Thien Nguyen, Vivien Ya-Fan Wang, Yidan Li, Tapan Biswas, Gourisankar Ghosh   +6 more
openaire   +4 more sources

The cellular state determines the effect of melatonin on the survival of mixed cerebellar cell culture. [PDF]

PLoS ONE, 2014
The constitutive activation of nuclear factor-κB (NF-κB), a key transcription factor involved in neuroinflammation, is essential for the survival of neurons in situ and of cerebellar granule cells in culture.
Daiane Gil Franco, Regina P Markus
doaj   +1 more source

Activation of Nuclear Factor-κB-dependent Transcription by Tumor Necrosis Factor-α Is Mediated through Phosphorylation of RelA/p65 on Serine 529 [PDF]

Journal of Biological Chemistry, 1998
Nuclear factor-κB (NF-κB) is an essential transcription factor in the control of expression of genes involved in immune and inflammatory responses. In unstimulated cells, NF-κB complexes are sequestered in the cytoplasm through interactions with IκBα and other IκB proteins.
D, Wang, A S, Baldwin
openaire   +2 more sources

Differential RelA- and RelB-dependent gene transcription in LTβR-stimulated mouse embryonic fibroblasts

BMC Genomics, 2008
Background Lymphotoxin signaling via the lymphotoxin-β receptor (LTβR) has been implicated in biological processes ranging from development of secondary lymphoid organs, maintenance of spleen architecture, host defense against pathogens, autoimmunity ...
Yilmaz Z Buket, Albrecht Daniela, Radke Dörte, Lovas Agnes, Möller Ulrich, Habenicht Andreas JR, Weih Falk   +6 more
doaj   +1 more source