Results 41 to 50 of about 2,461,635 (330)

Transcription factor dynamics

Microbiology, 2008
Gene expression is a fundamental process that is highly conserved from humans to bacteria. The first step in gene expression, transcription, is performed by structurally conserved DNA-dependent RNA polymerases (RNAPs), which results in the synthesis of an RNA molecule from a DNA template.
Lewis, P. J., Doherty, G. P., Clarke, J.
openaire   +4 more sources

Regulation of Transcription Elongation and Termination

Biomolecules, 2015
This article will review our current understanding of transcription elongation and termination in E. coli. We discuss why transcription elongation complexes pause at certain template sites and how auxiliary host and phage transcription factors affect ...
Robert S. Washburn, Max E. Gottesman
doaj   +1 more source

A dynamic mode of mitotic bookmarking by transcription factors. [PDF]

, 2016
During mitosis, transcription is shut off, chromatin condenses, and most transcription factors (TFs) are reported to be excluded from chromosomes. How do daughter cells re-establish the original transcription program? Recent discoveries that a select set
An, Luye, Darzacq, Xavier, Hansen, Anders S, Teves, Sheila S, Tjian, Robert, Xie, Liangqi   +5 more
core   +1 more source

Hsp90 the concertmaster: tuning transcription

Frontiers in Oncology, 2015
In the last decade Hsp90 has emerged as a major regulator of cancer cell growth and proliferation. In cancer cells, it assists in giving maturation to oncogenic proteins including several kinases and transcription factors.
Nidhi eKhurana, Sunanda eBhattacharyya
doaj   +1 more source

Sweet Melody or Jazz? Transcription Around DNA Double-Strand Breaks

Frontiers in Molecular Biosciences, 2021
Genomic integrity is continuously threatened by thousands of endogenous and exogenous damaging factors. To preserve genome stability, cells developed comprehensive DNA damage response (DDR) pathways that mediate the recognition of damaged DNA lesions ...
Qilin Long, Zhichao Liu, Monika Gullerova   +2 more
doaj   +1 more source

LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. [PDF]

, 2014
Transcriptional elongation by RNA polymerase (Pol) II is essential for gene expression during cell growth and differentiation. The positive transcription elongation factor b (P-TEFb) stimulates transcriptional elongation by phosphorylating Pol II and ...
Ji, Xiaodan, Lu, Huasong, Luo, Kunxin, Zhou, Qiang   +3 more
core   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

An RxLR effector from phytophthora infestans prevents re-localisation of two plant NAC transcription factors from the endoplasmic reticulum to the nucleus [PDF]

, 2013
The plant immune system is activated following the perception of exposed, essential and invariant microbial molecules that are recognised as non-self. A major component of plant immunity is the transcriptional induction of genes involved in a wide array ...
A Block, A Bombarely, A Stamatakis, AN Olsen, AO Avrova, AP Rehmany, BJ Haas, BM Tyler, Brett Tyler, C Lacomme, C Zipfel, D Chinchilla, D Darriba, D Dou, DGO Saunders, EA van der Biezen, EM Gilroy, EM Gilroy, G Fabro, H-K Yoon, Hazel McLellan, HM Nguyen, HP Nguyen, I Hein, JD Jones, JIB Bos, Jim L. Beynon, JL Dangl, Juan Morales, K Bouwmeester, L Baxter, L Deslandes, Leighton Pritchard, M Karimi, M-C Caillaud, MD Curtis, Miles R. Armstrong, MS Mukhtar, N Ishihama, NK Clay, P Chomczynski, Paul R. J. Birch, Petra C. Boevink, PJ Seo, PJ Seo, PRJ Birch, PRJ Birch, Q Wang, S Capella-Gutierrez, S Dong, S Lee, S Moller, S Puranik, S Rivas, S-G Kim, S-Y Kim, SC Whisson, SK Oh, Sonia Gomez, SR Eddy, Stephen C. Whisson, T Boller, T Hoppe, T Ren, T Ren, TO Bozkurt, V Senchou, Y Liu, Y-J Lu, Y-S Kim, Z Nimchuk   +70 more
core   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source