Results 41 to 50 of about 2,449,499 (289)

The T-cell oncogene Tal2 is a Target of PU.1 and upregulated during osteoclastogenesis [PDF]

, 2013
Transcription factors play a crucial role in regulating differentiation processes during human life and are important in disease. The basic helix-loop-helix transcription factors Tal1 and Lyl1 play a major role in the regulation of gene expression in the
Courtial, Nadine, Herkt, Stefanie, Hussong, Helge, Kolodziej, Stephan, Lausen, Jörn, Mücke, Christian   +5 more
core   +7 more sources

Patient‐Level Barriers and Facilitators to Inpatient Physical Therapy in Adolescents and Young Adults With a Hematological Malignancy: A Qualitative Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite their increased risk for functional impairment resulting from cancer and its treatments, few adolescents and young adults (AYAs) with a hematological malignancy receive the recommended or therapeutic dose of exercise per week during inpatient hospitalizations.
Jennifer A. Kelleher, Jennifer L. Bernstein, Katia M. Crisler, Julia K. Herriott, Kimberly L. Klages, Robin E. Norris, Mariann L. Strenk, Sarah E. Bills, Meghan E. McGrady   +8 more
wiley   +1 more source

An RxLR effector from phytophthora infestans prevents re-localisation of two plant NAC transcription factors from the endoplasmic reticulum to the nucleus [PDF]

, 2013
The plant immune system is activated following the perception of exposed, essential and invariant microbial molecules that are recognised as non-self. A major component of plant immunity is the transcriptional induction of genes involved in a wide array ...
A Block, A Bombarely, A Stamatakis, AN Olsen, AO Avrova, AP Rehmany, BJ Haas, BM Tyler, Brett Tyler, C Lacomme, C Zipfel, D Chinchilla, D Darriba, D Dou, DGO Saunders, EA van der Biezen, EM Gilroy, EM Gilroy, G Fabro, H-K Yoon, Hazel McLellan, HM Nguyen, HP Nguyen, I Hein, JD Jones, JIB Bos, Jim L. Beynon, JL Dangl, Juan Morales, K Bouwmeester, L Baxter, L Deslandes, Leighton Pritchard, M Karimi, M-C Caillaud, MD Curtis, Miles R. Armstrong, MS Mukhtar, N Ishihama, NK Clay, P Chomczynski, Paul R. J. Birch, Petra C. Boevink, PJ Seo, PJ Seo, PRJ Birch, PRJ Birch, Q Wang, S Capella-Gutierrez, S Dong, S Lee, S Moller, S Puranik, S Rivas, S-G Kim, S-Y Kim, SC Whisson, SK Oh, Sonia Gomez, SR Eddy, Stephen C. Whisson, T Boller, T Hoppe, T Ren, T Ren, TO Bozkurt, V Senchou, Y Liu, Y-J Lu, Y-S Kim, Z Nimchuk   +70 more
core   +4 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

WRKY transcription factors in legumes

BMC Plant Biology, 2018
Background WRKY transcription factors, so named because of the WRKYGQK heptapeptide at the N-terminal end, are widely distributed in plants and play an important role in physiological changes and response to biotic and abiotic stressors.
Hui Song, Weihong Sun, Guofeng Yang, Juan Sun   +3 more
doaj   +1 more source

Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles [PDF]

, 1994
Elevation of cAMP can cause gene-specific inhibition of interleukin 2 (IL-2) expression. To investigate the mechanism of this effect, we have combined electrophoretic mobility shift assays and in vivo genomic footprinting to assess both the availability ...
Chen, Dan, Rothenberg, Ellen V.
core   +2 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Transcription factors - Methods and protocols

European Journal of Histochemistry, 2011
A hearty wellcome to prof. Higgins editorial toil: a necessary tool for those colleagues (young and older) fighting each day with the transcription factor they are involved with.
CarloAlberto Redi
doaj   +1 more source

Dynamic multifactor hubs interact transiently with sites of active transcription in Drosophila embryos. [PDF]

, 2018
The regulation of transcription requires the coordination of numerous activities on DNA, yet how transcription factors mediate these activities remains poorly understood.
Darzacq, Xavier, Eisen, Michael B, Hannon, Colleen E, Harrison, Melissa M, Mir, Mustafa, Ortiz, Stephan A, Stadler, Michael R   +6 more
core   +1 more source

LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. [PDF]

, 2014
Transcriptional elongation by RNA polymerase (Pol) II is essential for gene expression during cell growth and differentiation. The positive transcription elongation factor b (P-TEFb) stimulates transcriptional elongation by phosphorylating Pol II and ...
Ji, Xiaodan, Lu, Huasong, Luo, Kunxin, Zhou, Qiang   +3 more
core   +3 more sources