Results 41 to 50 of about 15,365,257 (385)
A global function for transcription factors in assisting RNA polymerase II termination. [PDF]
, 2017 The role of transcription factors (TFs) on nucleosome positioning, RNA polymerase recruitment, and transcription initiation has been extensively characterized.
Chanfreau, Guillaume F, Roy, Kevin
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Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands [PDF]
, 1998 Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis.
Baird, Eldon E. +6 more
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Transposon-derived transcription factors across metazoans
Frontiers in Cell and Developmental Biology, 2023 Transposable elements (TE) could serve as sources of new transcription factors (TFs) in plants and some other model species, but such evidence is lacking for most animal lineages. Here, we discovered multiple independent co-options of TEs to generate 788
Krishanu Mukherjee +2 more
doaj +1 more source
Microbiology, 2008 Gene expression is a fundamental process that is highly conserved from humans to bacteria. The first step in gene expression, transcription, is performed by structurally conserved DNA-dependent RNA polymerases (RNAPs), which results in the synthesis of an RNA molecule from a DNA template.
Lewis, P. J., Doherty, G. P., Clarke, J.
openaire +5 more sources
A dynamic mode of mitotic bookmarking by transcription factors. [PDF]
, 2016 During mitosis, transcription is shut off, chromatin condenses, and most transcription factors (TFs) are reported to be excluded from chromosomes. How do daughter cells re-establish the original transcription program? Recent discoveries that a select set
An, Luye +5 more
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Fungal CSL transcription factors
BMC Genomics, 2007 Background The CSL (CBF1/RBP-Jκ/Suppressor of Hairless/LAG-1) transcription factor family members are well-known components of the transmembrane receptor Notch signaling pathway, which plays a critical role in metazoan development.
Folk Petr +2 more
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Targeted Degradation of Transcription Factors by TRAFTACs: Transcription Factor Targeting Chimeras
bioRxiv, 2020 Many diseases, including cancer, stem from aberrant activation and overexpression of oncoproteins that are associated with multiple signaling pathways. Although proteins with catalytic activity are able to be successfully drugged, the majority of other ...
Kusal T. G. Samarasinghe +4 more
semanticscholar +1 more source
Temperature-sensitive protein–DNA dimerizers [PDF]
, 2005 Programmable DNA-binding polyamides coupled to short peptides have led to the creation of synthetic artificial transcription factors. A hairpin polyamide-YPWM tetrapeptide conjugate facilitates the binding of a natural transcription factor Exd to an ...
Ansari, Aseem Z. +6 more
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Regulation of Transcription Elongation and Termination
Biomolecules, 2015 This article will review our current understanding of transcription elongation and termination in E. coli. We discuss why transcription elongation complexes pause at certain template sites and how auxiliary host and phage transcription factors affect ...
Robert S. Washburn, Max E. Gottesman
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Nr4a transcription factors limit CAR T cell function in solid tumors
Nature, 2019 T cells expressing chimeric antigen receptors (CAR T cells) targeting human CD19 (hCD19) have shown clinical efficacy against B cell malignancies1,2.
Joyce Chen +8 more
semanticscholar +1 more source