Results 51 to 60 of about 15,143,293 (401)

Transcription factors organize into functional groups on the linear genome and in 3D chromatin

Heliyon, 2023
Transcription factors (TFs) and their binding sites have evolved to interact cooperatively or competitively with each other. Here we examine in detail, across multiple cell lines, such cooperation or competition among TFs both in sequential and spatial ...
Rakesh Netha Vadnala, Sridhar Hannenhalli, Leelavati Narlikar, Rahul Siddharthan   +3 more
doaj  

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance A recent exciting development in cancer therapy involves using a patient’s own immune system to attack cancers. The attack is carried out by CD8+ T cells that destroy the malignant cells; after infiltrating tumors, however, these cells ...
Hyungseok Seo, Joyce Chen, Edahí González-Avalos, Daniela Samaniego-Castruita, Arundhoti Das, Yueqiang H. Wang, Isaac F. López-Moyado, Romain O. Georges, Wade Zhang, A. Onodera, Cheng-Jang Wu, Li-Fan Lu, P. Hogan, A. Bhandoola, A. Rao   +14 more
semanticscholar   +1 more source

TFE and Spt4/5 open and close the RNA polymerase clamp during the transcription cycle [PDF]

, 2016
Transcription is an intrinsically dynamic process and requires the coordinated interplay of RNA polymerases (RNAPs) with nucleic acids and transcription factors.
Gietl, Andreas, Grohmann, Dina, Schulz, Sarah, Smollett, Katherine, Tinnefeld, Philip, Werner, Finn   +5 more
core   +1 more source

Multiple mechanisms of growth hormone-regulated gene transcription [PDF]

, 2007
Diverse physiological actions of growth hormone (GH) are mediated by changes in gene transcription. Transcription can be regulated at several levels, including post-translational modification of transcription factors, and formation of multiprotein ...
Calinescu, Anda Alexandra, Ceseña, Teresa I., Cui, Tracy Xiao, Huo, Jeffrey S., Iñiguez Lluhí, Jorge A., Kaplani, Julianne, Kwok, Roland, Piwien Pilipuk, Graciela, Schwartz, Jessica   +8 more
core   +1 more source

Hsp90 the concertmaster: tuning transcription

Frontiers in Oncology, 2015
In the last decade Hsp90 has emerged as a major regulator of cancer cell growth and proliferation. In cancer cells, it assists in giving maturation to oncogenic proteins including several kinases and transcription factors.
Nidhi eKhurana, Sunanda eBhattacharyya
doaj   +1 more source

Sweet Melody or Jazz? Transcription Around DNA Double-Strand Breaks

Frontiers in Molecular Biosciences, 2021
Genomic integrity is continuously threatened by thousands of endogenous and exogenous damaging factors. To preserve genome stability, cells developed comprehensive DNA damage response (DDR) pathways that mediate the recognition of damaged DNA lesions ...
Qilin Long, Zhichao Liu, Monika Gullerova   +2 more
doaj   +1 more source

Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands [PDF]

, 1998
Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis.
Baird, Eldon E., Dervan, Peter B., Dickinson, Liliane A., Gottesfeld, Joel M., Gulizia, Richard J., Mosier, Donald E., Trauger, John W.   +6 more
core   +1 more source

AnimalTFDB 3.0: a comprehensive resource for annotation and prediction of animal transcription factors

Nucleic Acids Res., 2018
The Animal Transcription Factor DataBase (AnimalTFDB) is a resource aimed to provide the most comprehensive and accurate information for animal transcription factors (TFs) and cofactors.
Hui Hu, Ya-Ru Miao, Longhao Jia, Qingyang Yu, Qiong Zhang, An-Yuan Guo   +5 more
semanticscholar   +1 more source

Transforming a transcription factor

eLife, 2018
A transcription factor that regulates skeleton formation in sea urchin embryos has evolved a new domain that is essential for this process.
openaire   +4 more sources

Thyroid-specific transcription factors control Hex promoter activity [PDF]

, 2003
The homeobox-containing gene Hex is expressed in several cell types, including thyroid follicular cells, in which it regulates the transcription of tissue-specific genes. In this study the regulation of Hex promoter activity was investigated.
A. V., D'Elia, C. W., Bogue, C., Puppin, D., Russo, F., Arturi, Filetti, Sebastiano, G., Damante, I., Presta, L. A., Denson, L., Pellizzari   +9 more
core   +1 more source