Results 51 to 60 of about 15,584,477 (336)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Nucleosome-mediated cooperativity between transcription factors [PDF]

, 2009
Cooperative binding of transcription factors (TFs) to cis-regulatory regions (CRRs) is essential for precision of gene expression in development and other processes.
Adams, Anderson, Arnosti, Arnosti, Berman, Bintu, Changeux, Chen, Dion, Gao, Hare, Ioshikhes, Ioshikhes, Iyer, John, Kaplan, Kim, L. A. Mirny, Lam, Lee, Lee, Li, Li, Li, Lin, Maerkl, Mavrich, Miller, Monod, Morse, Moses, Oliviero, Panne, Pettersson, Phair, Poirier, Polach, Polach, Ransom, Sabo, Saiz, Segal, Sinha, Tillo, Trifonov, Vashee, Weinberg, Wunderlich, Xu, Zhang   +49 more
core   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The interplay between chromatin and transcription factor networks during B cell development: who pulls the trigger first?

Frontiers in Immunology, 2014
All mature blood cells derive from hematopoietic stem cells (HSCs) through gradual restriction of their cell fate potential and acquisition of specialized functions.
Mohamed-Amin eChoukrallah, Patrick eMatthias   +1 more
doaj   +1 more source

AnimalTFDB 3.0: a comprehensive resource for annotation and prediction of animal transcription factors

Nucleic Acids Res., 2018
The Animal Transcription Factor DataBase (AnimalTFDB) is a resource aimed to provide the most comprehensive and accurate information for animal transcription factors (TFs) and cofactors.
Hui Hu, Ya-Ru Miao, Longhao Jia, Qingyang Yu, Qiong Zhang, An-Yuan Guo   +5 more
semanticscholar   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

Distinct transcriptomic features are associated with transitional and mature B-cell populations in the mouse spleen

Frontiers in Immunology, 2015
Splenic transitional B-cells (T1 and T2) are selected to avoid self-reactivity and to safeguard against autoimmunity, then differentiate into mature follicular (FO-I and FO-II) and marginal zone (MZ) subsets.
Eden eKleiman, Daria eSalyakina, Magali eDe Heusch, Magali eDe Heusch, Kristen L Hoek, Joan M Llanes, Iris eCastro, Jacqueline A Wright, Emily S Clark, Derek Michael Dykxhoorn, Akiko eTakeda, Enrico eCapobianco, Jean-Christophe eRenauld, Jean-Christophe eRenauld, Wasif N Khan   +14 more
doaj   +1 more source

Zygotic pioneer factor activity of Odd-paired/Zic is necessary for late function of the Drosophila segmentation network

eLife, 2020
Because chromatin determines whether information encoded in DNA is accessible to transcription factors, dynamic chromatin states in development may constrain how gene regulatory networks impart embryonic pattern.
Isabella V Soluri, Lauren M Zumerling, Omar A Payan Parra, Eleanor G Clark, Shelby A Blythe   +4 more
doaj   +1 more source

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

WRKY transcription factors in legumes

BMC Plant Biology, 2018
Background WRKY transcription factors, so named because of the WRKYGQK heptapeptide at the N-terminal end, are widely distributed in plants and play an important role in physiological changes and response to biotic and abiotic stressors.
Hui Song, Weihong Sun, Guofeng Yang, Juan Sun   +3 more
doaj   +1 more source