Results 31 to 40 of about 2,065,027 (229)

The Nuclear Lamina as an Organizer of Chromosome Architecture

Cells, 2019
The nuclear lamina (NL) is a meshwork of lamins and lamin-associated proteins adjoining the inner side of the nuclear envelope. In early embryonic cells, the NL mainly suppresses background transcription, whereas, in differentiated cell types, its ...
Yuri Y. Shevelyov, Sergey V. Ulianov
doaj   +1 more source

Extending the dynamic range of transcription factor action by translational regulation

, 2015
A crucial step in the regulation of gene expression is binding of transcription factor (TF) proteins to regulatory sites along the DNA. But transcription factors act at nanomolar concentrations, and noise due to random arrival of these molecules at their
Bialek, William, Sokolowski, Thomas R., Tkačik, Gašper, Walczak, Aleksandra M.   +3 more
core   +1 more source

icaR and icaT are Ancient Chromosome Genes Encoding Substrates of the Type III Secretion Apparatus in Shigella flexneri

mSphere, 2022
Shigella is an Escherichia coli pathovar that colonizes the cytosol of mucosal cells in the human large intestine. To do this, Shigella uses a Type III Secretion Apparatus (T3SA) to translocate several proteins into host cells.
Navoun Silué, François-Xavier Campbell-Valois   +1 more
doaj   +1 more source

Computational identification of transcription factor binding sites by functional analysis of sets of genes sharing overrepresented upstream motifs [PDF]

, 2004
BACKGROUND: Transcriptional regulation is a key mechanism in the functioning of the cell, and is mostly effected through transcription factors binding to specific recognition motifs located upstream of the coding region of the regulated gene.
Caselle, Michele, Cora', Davide, Di Cunto, Ferdinando, Provero, Paolo, Silengo, Lorenzo   +4 more
core   +4 more sources

Role of FlhF and its domains in the assembly of a polar flagellum in P. aeruginosa

Journal of Bacteriology
FlhF, an SRP GTPase, regulates the polarity and flagellation patterns in various bacteria, including Pseudomonas aeruginosa. FlhF is a multidomain protein that comprises three domains: B, N, and G, or the GTPase domain.
Shikha Raghav, Rohit Prajapati, Deepti Jain   +2 more
doaj   +1 more source

Epiregulin (EREG) and Myocardin Related Transcription Factor A (MRTF-A) Form a Feedforward Loop to Drive Hepatic Stellate Cell Activation

Frontiers in Cell and Developmental Biology, 2021
Trans-differentiation of quiescent hepatic stellate cells (HSC) into myofibroblast cells is considered the linchpin of liver fibrosis. A myriad of signaling pathways contribute to HSC activation and consequently liver fibrosis.
Xiaoyan Wu, Xiaoyan Wu, Xiaoyan Wu, Wenhui Dong, Tianyi Zhang, Haozhen Ren, Haozhen Ren, Jinglin Wang, Jinglin Wang, Longcheng Shang, Zhengyi Zhu, Wei Zhu, Xiaolei Shi, Xiaolei Shi, Yong Xu, Yong Xu   +15 more
doaj   +1 more source

Transcriptional Regulation by P53 [PDF]

Cold Spring Harbor Perspectives in Biology, 2010
Inactivation of p53 is critical for the formation of most tumors. Illumination of the key function(s) of p53 protein in protecting cells from becoming cancerous is therefore a worthy goal. Arguably p53's most important function is to act as a transcription factor that directly regulates perhaps several hundred of the cell's RNA polymerase II (RNAP II ...
Rachel, Beckerman, Carol, Prives
openaire   +2 more sources

PfAP2-EXP2, an Essential Transcription Factor for the Intraerythrocytic Development of Plasmodium falciparum

Frontiers in Cell and Developmental Biology, 2022
Plasmodium falciparum undergoes a series of asexual replications in human erythrocytes after infection, which are effective targets for combatting malaria.
Xiaomin Shang, Xiaomin Shang, Changhong Wang, Li Shen, Fei Sheng, Xiaohui He, Xiaohui He, Fei Wang, Yanting Fan, Xiaoqin He, Mei Jiang   +10 more
doaj   +1 more source

Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features. [PDF]

, 2019
Empirical evidence suggests that the malaria parasite Plasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism's complex life cycle.
Cook, Kate, Le Roch, Karine G, Lu, Yang Y, Noble, William Stafford, Read, David F   +4 more
core   +2 more sources

Regulation of HSV Transcription.

Journal of Investigative Dermatology, 1984
Herpes simplex virus (HSV) transcripts share many features with both cellular mRNA and the mRNAs expressed by other nuclear-replicating DNA viruses: they are capped, polyadenylated, and generally have an approximately 150 base leader between the cap and translation initiation codon.
openaire   +2 more sources