Results 41 to 50 of about 5,538,535 (384)

ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes [PDF]

open access: yes, 2007
ChIP-on-chip has emerged as a powerful tool to dissect the complex network of regulatory interactions between transcription factors and their targets.
A. A. Ferrando   +27 more
core   +3 more sources

Evaluation of seaweed sulfated polysaccharides as natural antagonists targeting Salmonella typhi OmpF: molecular docking and pharmacokinetic profiling

open access: yesBeni-Suef University Journal of Basic and Applied Sciences, 2022
Background Salmonella belongs to the Enterobacteriaceae family, a gram-negative, non-spore-forming, rod-shaped, motile, and pathogenic bacteria that transmit through unhygienic conditions.
Malaisamy Arunkumar   +7 more
doaj   +1 more source

GTRD: a database on gene transcription regulation—2019 update

open access: yesNucleic Acids Res., 2018
The current version of the Gene Transcription Regulation Database (GTRD; http://gtrd.biouml.org) contains information about: (i) transcription factor binding sites (TFBSs) and transcription coactivators identified by ChIP-seq experiments for Homo sapiens,
I. Yevshin   +4 more
semanticscholar   +1 more source

Glutathione Transferases Are Involved in the Genotype-Specific Salt-Stress Response of Tomato Plants

open access: yesAntioxidants, 2023
Glutathione transferases (GSTs) are one of the most versatile multigenic enzyme superfamilies. In our experiments, the involvement of the genotype-specific induction of GST genes and glutathione- or redox-related genes in pathways regulating salt-stress ...
Edit Horváth   +7 more
doaj   +1 more source

The Nuclear Lamina as an Organizer of Chromosome Architecture

open access: yesCells, 2019
The nuclear lamina (NL) is a meshwork of lamins and lamin-associated proteins adjoining the inner side of the nuclear envelope. In early embryonic cells, the NL mainly suppresses background transcription, whereas, in differentiated cell types, its ...
Yuri Y. Shevelyov, Sergey V. Ulianov
doaj   +1 more source

Rtf1 Transcriptionally Regulates Neonatal and Adult Cardiomyocyte Biology

open access: yesJournal of Cardiovascular Development and Disease, 2023
The PAF1 complex component Rtf1 is an RNA Polymerase II-interacting transcription regulatory protein that promotes transcription elongation and the co-transcriptional monoubiquitination of histone 2B.
Adam D. Langenbacher   +8 more
doaj   +1 more source

YEASTRACT+: a portal for cross-species comparative genomics of transcription regulation in yeasts

open access: yesNucleic Acids Res., 2019
The YEASTRACT+ information system (http://YEASTRACT-PLUS.org/) is a wide-scope tool for the analysis and prediction of transcription regulatory associations at the gene and genomic levels in yeasts of biotechnological or human health relevance. YEASTRACT+
Pedro T. Monteiro   +14 more
semanticscholar   +1 more source

Transcriptional Regulation by Nrf2

open access: yesAntioxidants & Redox Signaling, 2018
Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes. Understanding the regulation of Nrf2 activity and downstream pathways has major implications for human health.
Claudia Tonelli   +3 more
openaire   +4 more sources

Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands [PDF]

open access: yes, 1998
Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis.
Baird, Eldon E.   +6 more
core   +1 more source

Transcriptional Regulation by P53 [PDF]

open access: yesCold Spring Harbor Perspectives in Biology, 2010
Inactivation of p53 is critical for the formation of most tumors. Illumination of the key function(s) of p53 protein in protecting cells from becoming cancerous is therefore a worthy goal. Arguably p53's most important function is to act as a transcription factor that directly regulates perhaps several hundred of the cell's RNA polymerase II (RNAP II ...
Carol Prives, Rachel Beckerman
openaire   +3 more sources

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