Results 41 to 50 of about 2,065,027 (229)

Structural basis of measles virus polymerase inhibition by nonnucleoside inhibitor ERDRP-0519

Nature Communications
ERDRP-0519 is a potent nonnucleoside inhibitor active against measles virus (MeV) and other Morbilliviruses. Here we report cryo-EM structures of the compound bound to MeV polymerase complexes at 2.73 Å and 2.48 Å resolution, revealing a unique binding ...
Dong Wang, Fan Bu, Ge Yang, Bin Liu
doaj   +1 more source

Optogenetic regulation of transcription

BMC Neuroscience, 2018
Optogenetics has become widely recognized for its success in real-time control of brain neurons by utilizing non-mammalian photosensitive proteins to open or close membrane channels.
Oksana Polesskaya, Ancha Baranova, Sarah Bui, Nikolai Kondratev, Evgeniya Kananykhina, Olga Nazarenko, Tatyana Shapiro, Frances Barg Nardia, Vladimir Kornienko, Vikas Chandhoke, Istvan Stadler, Raymond Lanzafame, Max Myakishev-Rempel   +12 more
doaj   +1 more source

Regulation of Transcript Elongation [PDF]

Annual Review of Microbiology, 2015
Bacteria lack subcellular compartments and harbor a single RNA polymerase that synthesizes both structural and protein-coding RNAs, which are cotranscriptionally processed by distinct pathways. Nascent rRNAs fold into elaborate secondary structures and associate with ribosomal proteins, whereas nascent mRNAs are translated by ribosomes.
Georgiy A, Belogurov, Irina, Artsimovitch   +1 more
openaire   +2 more sources

Dynamic Crowding Regulates Transcription [PDF]

Biophysical Journal, 2020
The nuclear environment is highly crowded by biological macromolecules, including chromatin and mobile proteins, which alter the kinetics and efficiency of transcriptional machinery. These alterations have been described, both theoretically and experimentally, for steady-state crowding densities; however, temporal changes in crowding density ("dynamic ...
Anne R. Shim, Rikkert J. Nap, Kai Huang, Luay M. Almassalha, Hiroaki Matusda, Vadim Backman, Igal Szleifer   +6 more
openaire   +2 more sources

Structure of the measles virus ternary polymerase complex

Nature Communications
Measles virus (MeV) is a highly contagious pathogen that causes significant morbidity worldwide. Its polymerase machinery, composed of the large protein (L) and phosphoprotein (P), is crucial for viral replication and transcription, making it a promising
Dong Wang, Ge Yang, Bin Liu
doaj   +1 more source

A connection between stress and development in the multicelular prokaryote Streptomyces coelicolor [PDF]

, 2001
Morphological changes leading to aerial mycelium formation and sporulation in the mycelial bacterium Streptomyces coelicolor rely on establishing distinct patterns of gene expression in separate regions of the colony.
Bucca G., Champness W.C., Charles J. Thompson, Chater K.F., Elliot M., Elliot M.A., Gabriella H. Kelemen, Jennifer Tenor, Kelemen G.H., Kieser T., Laura Marri, Mandic-Mulec I., Mark J. Buttner, Merrick M.J., Patrick H. Viollier, Potuckova L., Price C.W., Ryding N.J., Schwedock J., Sun J., Vohradsky J., Volker U., Westpheling J., Willey J., Yang X.   +24 more
core   +1 more source

Spatial clustering and common regulatory elements correlate with coordinated gene expression [PDF]

, 2019
Many cellular responses to surrounding cues require temporally concerted transcriptional regulation of multiple genes. In prokaryotic cells, a single-input-module motif with one transcription factor regulating multiple target genes can generate ...
Bai, Fan, Chen, Hengyu, Li, Ruoyan, Taft, David A., Xing, Jianhua, Yao, Guang, Zhang, Jingyu   +6 more
core   +3 more sources

Structure of the Nipah virus polymerase phosphoprotein complex

Nature Communications
The Nipah virus (NiV), a member of the Paramyxoviridae family, is notorious for its high fatality rate in humans. The RNA polymerase machinery of NiV, comprising the large protein L and the phosphoprotein P, is essential for viral replication. This study
Ge Yang, Dong Wang, Bin Liu
doaj   +1 more source

DoGFinder: a software for the discovery and quantification of readthrough transcripts from RNA-seq

BMC Genomics, 2018
Background Recent studies have described a widespread induction of transcriptional readthrough as a consequence of various stress conditions in mammalian cells.
Yuval Wiesel, Niv Sabath, Reut Shalgi
doaj   +1 more source

Research Progress on Regulation of Antioxidant Transcription in Reactive Oxygen Species Metabolism of Postharvest Fruits and Vegetables during Low Temperature Storage

Shipin gongye ke-ji, 2023
Imbalance of active oxygen metabolism can lead to oxidative stress in postharvest fruits and vegetables, which could accelerate their quality deterioration, and ruin their commercial value.
Yang YANG, Qiqi CHEN, Lihong GUO, Quannü YANG, Fuwang WU   +4 more
doaj   +1 more source