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Transcription Termination

Critical Reviews in Biochemistry and Molecular Biology, 1993
Chromosomes are organized into units of expression that are bounded by sites where transcription of DNA sequences into RNA is initiated and terminated. To allow for efficient stepwise assembly of complete transcripts, the transcribing enzyme (RNA polymerase) makes a stable complex with the DNA template until it reaches the terminator.
John P. Richardson, Jeffrey W. Roberts
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Control of Transcription Termination

Annual Review of Biochemistry, 1978
PERSPECTIVES AND SUMMARY 967 WHAT IS TRANSCRIPTION TERMINATION? 96S RHO-INDEPENDENT TERMINATION 969 RHO-DEPENDENT TERMINATION 972 THE SEQUENCES OF SOME TRANSCRIPTION TERMINATION SIGNALS.. 974 THE MECHANISM OF ACTION OF RHO ... 979 TRANSCRIPTION TERMINATION IN VIVO: A MODEL 9S2 Polarity: Transcription Termination with Operons ... ... ....
S, Adhya, M, Gottesman
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Structural dissection of an interaction between transcription initiation and termination factors implicated in promoter-terminator cross-talk

open access: yesJournal of Biological Chemistry, 2018
Functional cross-talk between the promoter and terminator of a gene has long been noted. Promoters and terminators are juxtaposed to form gene loops in several organisms, and gene looping is thought to be involved in transcriptional regulation.
Lizhe Zhu   +2 more
exaly   +2 more sources

The Elongation-Termination Decision in Transcription

Science, 1992
At any template position, the decision to extend the transcript by one residue or to release the nascent RNA represents a kinetic competition between elongation and termination pathways. This competition is discussed in terms of alternative Eyring transition state barriers; changes in termination efficiency correspond to small changes in the relative ...
von Hippel, Peter H., Yager, Thomas D.
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Rho-dependent termination and ATPases in transcript termination

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2002
Transcription factor Rho is a ring-shaped, homohexameric protein that causes transcript termination through actions on nascent RNAs that are coupled to ATP hydrolysis. The Rho polypeptide has a distinct RNA-binding domain (RNA-BD) of known structure as well as an ATP-binding domain (ATP-BD) for which a structure has been proposed based on homology ...
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Coupling of transcription termination to RNAi

Journal of Theoretical Biology, 2007
In metazoans, the mechanisms of transcriptional termination by RNA polymerase II (Pol II) and accelerated decay of messenger RNA (mRNA) following transcription shutdown are linked by sharing the same sequence elements and mRNA elongation, processing and termination factors.
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Transcription termination in the dnaA gene

Molecular and General Genetics MGG, 1991
The termination of transcription in the dnaA gene of E. coli was analyzed using transcriptional fusions to the galactokinase gene, S1 nuclease mapping and quantification of translation products by Western blots. The majority of transcripts originating from dnaA promoters terminated at several positions within a 200 bp region inside the dnaA reading ...
M, Wende   +4 more
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Detection and Characterization of Transcription Termination

2011
In most eukaryotes, the generation of the 3' end and transcription termination are initiated by cleavage of the pre-mRNA upstream of the polyadenylation site. This cleavage initiates 5'-3' degradation of the 3' end cleavage product by the exoribonuclease Rat1p leading to the dissociation of the RNA polymerase II (RNAPII) complex.
Ghada, Ghazal   +2 more
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CONTROL OF TRANSCRIPTION TERMINATION IN PROKARYOTES

Annual Review of Genetics, 1996
▪ Abstract  A growing number of genetic systems have been shown to be controlled at the level of premature termination of transcription. Genes in this class contain transcription termination signals in the region upstream of the coding sequence. The activity of these regulatory termination signals is controlled through a variety of mechanisms.
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Mechanisms of Bacterial Transcription Termination

Journal of Molecular Biology, 2019
Bacterial transcription termination, described mostly for Escherichia coli, occurs in three recognized ways: intrinsic termination, an activity only of the core RNAP enzyme and transcript sequences that encode an RNA hairpin and terminal uridine-rich segment; termination by the enzyme Rho, an ATP-dependent RNA translocase that releases RNA by forcing ...
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