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Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

open access: yesAdvanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou   +9 more
wiley   +1 more source

Expression of bacteriocin LsbB is dependent on a transcription terminator [PDF]

open access: yesMicrobiological Research, 2015
The production of LsbB, leaderless class II bacteriocin, is encoded by genes (lsbB and lmrB) located on plasmid pMN5 in Lactococcus lactis BGMN1-5. Heterologous expression of the lsbB gene using the pAZIL vector (pAZIL-lsbB) in L. lactis subsp.
Milan Kojic, Jelena Lozo, Natasa Tosic
exaly   +2 more sources

A transcription terminator located upstream of the mouse rDNA initiation site affects rRNA synthesis. [PDF]

open access: yesCell, 1986
Mouse ribosomal genes have a short sequence upstream of the transcription initiation site that is related in structure and function to the terminator boxes previously identified at the 3′ end of the transcription unit. This upstream terminator recognizes
Ingrid Grummt
exaly   +2 more sources

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