Results 71 to 80 of about 5,966,093 (336)

Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B transcription via interaction with MIZ-1 [PDF]

, 2014
The Epstein-Barr virus (EBV) nuclear antigen 3 family of protein is critical for the EBV-induced primary B-cell growth transformation process. Using a yeast two-hybrid screen we identified 22 novel cellular partners of the EBNA3s. Most importantly, among
Bazot, Q, Deschamps, T, Gruffat, H, Harth-Hertle, ML, Kempkes, B, Leblanc, P, Lotteau, V, Manet, E, Rabourdin-Combe, C, Siouda, M, Tafforeau, L, Tommasino, M   +11 more
core   +6 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Neuronal Cell-type Engineering by Transcriptional Activation

Frontiers in Genome Editing, 2021
Gene activation with the CRISPR-Cas system has great implications in studying gene function, controlling cellular behavior, and modulating disease progression. In this review, we survey recent studies on targeted gene activation and multiplexed screening
Songlei Liu, Songlei Liu, Johannes Striebel, Giovanni Pasquini, Alex H. M. Ng, Parastoo Khoshakhlagh, George M. Church, George M. Church, George M. Church, Volker Busskamp   +9 more
doaj   +1 more source

Transcriptional Regulation by Nrf2

Antioxidants and Redox Signaling, 2017
Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes.
C. Tonelli, I. I. C. Chio, D. Tuveson
semanticscholar   +1 more source

Wnt/β-catenin signaling stimulates the expression and synaptic clustering of the autism-associated Neuroligin 3 gene [PDF]

, 2018
Indexación: Scopus.Synaptic abnormalities have been described in individuals with autism spectrum disorders (ASD). The cell-adhesion molecule Neuroligin-3 (Nlgn3) has an essential role in the function and maturation of synapses and NLGN3 ASD-associated ...
Andrade, V.M., Avila, M.E., Caracci, M.O., De Ferrari, G.V., Medina, M.A., Opazo, C., Reyes, A.E., Ugarte, G.D., Vargas, M.F., Verdugo, D.A.   +9 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Identification of Egr1 as the oncostatin M-induced transcription activator that binds to sterol-independent regulatory element of human LDL receptor promoter

Journal of Lipid Research, 2002
Previously, we identified the low density lipoprotein receptor (LDLR) promoter region −17 to −1 as a novel sterol-independent regulatory element (SIRE) that mediates the stimulating effect of oncostatin M (OM).
Fang Zhang, Thomas E. Ahlborn, Cong Li, Fredric B. Kraemer, Jingwen Liu   +4 more
doaj   +1 more source

RFP represses transcriptional activation by bHLH transcription factors [PDF]

Oncogene, 2005
Basic helix-loop-helix (bHLH) transcription factors play a pivotal role in the regulation of tumorigenesis, and also in a wide range of other developmental processes in diverse species from yeast to humans. Here we demonstrate for the first time that Ret finger protein (RFP), a member of the TRIM family of proteins initially identified as a recombined ...
Adrian J C, Bloor, Ekaterina, Kotsopoulou, Penny, Hayward, Brian R, Champion, Anthony R, Green   +4 more
openaire   +2 more sources

Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers. [PDF]

, 2019
Although promoter-associated CpG islands have been established as targets of DNA methylation changes in cancer, previous studies suggest that epigenetic dysregulation outside the promoter region may be more closely associated with transcriptional changes.
Ando, Mizuo, Bui, Nam Q, Califano, Joseph A, Favorov, Alexander V, Fertig, Elana J, Fisch, Kathleen, Fukusumi, Takahito, Gaykalova, Daria A, Guo, Theresa, Ha, Patrick, Haft, Sunny, Ideker, Trey, Liu, Chao, Mark, Adam, Medetgul-Ernar, Kate, Messer, Karen, Pang, John, Pu, Minya, Ren, Shuling, Saito, Yuki, Sakai, Akihiro, Tamayo, Pablo, Xu, Guorong, Yamasoba, Tatsuya, Yegnasubramanian, Srinivasan   +24 more
core  

Functional analysis and binding affinity of tomato ethylene response factors provide insight on the molecular bases of plant differential responses to ethylene [PDF]

, 2012
Background : The phytohormone ethylene is involved in a wide range of developmental processes and in mediating plant responses to biotic and abiotic stresses.
Bouzayen, Mondher, Chen, Kunsong, Latché, Alain, Mila, Isabelle, Ohme-Takagi, Masaru, Pech, Jean-Claude, Pirrello, Julien, Prasad, Narasimha, Regad, Farid, Zhang, Wangshu, Zouine, Mohamed   +10 more
core   +5 more sources