Results 91 to 100 of about 41,997,054 (284)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Advances in the genetics of myasthenia gravis: insights from cutting-edge neuroscience research

Frontiers in Medicine
Myasthenia gravis (MG) is an autoimmune disorder involving complex interactions between genetic and environmental factors. Genome-wide association studies (GWAS), transcriptome-wide association studies (TWAS), and other methods have identified multiple ...
Zheng Yixian, Wang Hai, Liu Xiuying, Yan Jichun   +3 more
doaj   +1 more source

A Genome-Wide Integrative Association Study of DNA Methylation and Gene Expression Data and Later Life Cognitive Functioning in Monozygotic Twins

Frontiers in Neuroscience, 2020
Monozygotic twins are genetically identical but rarely phenotypically identical. Epigenetic and transcriptional variation could influence this phenotypic discordance.
Mette Soerensen, Mette Soerensen, Mette Soerensen, Dominika Marzena Hozakowska-Roszkowska, Dominika Marzena Hozakowska-Roszkowska, Marianne Nygaard, Marianne Nygaard, Martin J. Larsen, Martin J. Larsen, Veit Schwämmle, Kaare Christensen, Kaare Christensen, Kaare Christensen, Lene Christiansen, Lene Christiansen, Qihua Tan, Qihua Tan, Qihua Tan   +17 more
doaj   +1 more source

Using multi-tissue transcriptome-wide association study to identify candidate susceptibility genes for respiratory infectious diseases

Frontiers in Genetics, 2023
Objective: We explore the candidate susceptibility genes for influenza A virus (IAV), measles, rubella, and mumps and their underlying biological mechanisms.Methods: We downloaded the genome-wide association study summary data of four virus-specific ...
Xiaobo Zhu, Yixin Zou, Linna Jia, Xiangyu Ye, Yanzheng Zou, Junlan Tu, Juntong Li, Rongbin Yu, Sheng Yang, Peng Huang   +9 more
doaj   +1 more source

Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG. [PDF]

Invest Ophthalmol Vis Sci
Genome-wide association studies have identified numerous loci associated with POAG. However, functional insights remain limited owing to challenges from noncoding regions and complex linkage disequilibrium. We aimed to bridge these gaps in POAG by integrating genomic and multitissue transcriptomic data and identifying novel systemic regulatory genes.We
Chen J, Zhuo X, Li Y, Zhu Y, Li Z, Shen X, Zhuo Y, Tan H, Lei L.   +8 more
europepmc   +3 more sources

Finding genome-transcriptome-phenome association with structured association mapping and visualization in GenAMap.

, 2011
Despite the success of genome-wide association studies in detecting novel disease variants, we are still far from a complete understanding of the mechanisms through which variants cause disease.
Junming Yin (5363774), Ross E. Curtis (574088), Eric P Xing (27712), Peter Kinnaird (5363987)   +3 more
core   +1 more source

Codes for "Genome- and transcriptome-wide association studies to discover candidate genes for diverse root phenotypes in cultivated rice"

, 2023
This item includes all codes for "Genome- and transcriptome-wide association studies to discover candidate genes for diverse root phenotypes in cultivated rice". The statistical methods are described in the manuscript.
Ryokei Tanaka (16960911)
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights [PDF]

, 2018
Genome-wide association studies (GWAS) have identified over 100 risk loci for schizophrenia, but the causal mechanisms remain largely unknown. We performed a transcriptome-wide association study (TWAS) integrating a schizophrenia GWAS of 79,845 ...
Hyejung Won, Pasaniuc, Bogdan, Finucane, Hilary K., Geschwind, Daniel H., Katsanis, Nicholas, O'Donovan, Michael C., Kousi, Maria, Gusev, Alexander, Bogdan Pasaniuc, Sullivan, Patrick F., Yakir Reshef, Alkes L. Price, Daniel H. Geschwind, Gregory E. Crawford, Won, Hyejung, McCarroll, Steven, Reshef, Yakir, Crawford, Gregory E., Ophoff, Roel A., Nicholas Katsanis, Nicholas Mancuso, Mancuso, Nicholas, Safi, Alexias, Maria Kousi, Benjamin M. Neale, Price, Alkes L., Hilary K. Finucane, Steven McCarroll, Michael C. O’Donovan, O’Donovan, Michael C, Neale, Benjamin M., Geschwind, Daniel H, Sullivan, Patrick F, Crawford, Gregory E, Lingyun Song, Price, Alkes L, Song, Lingyun, null null, Ophoff, Roel A, Alexias Safi, Patrick F. Sullivan, Alexander Gusev, Neale, Benjamin M, Finucane, Hilary K, Roel A. Ophoff, Kousi, M, Safi, A, McCarroll, S, Finucane, HK, Mancuso, N, Song, L, Gusev, A, Reshef, Y, Won, H, Neale, BM   +54 more
core   +4 more sources

Genetic insights into the dissolution of dioecy in diploid persimmon Diospyros oleifera Cheng

BMC Plant Biology, 2023
Background Dioecy, a sexual system of single-sexual (gynoecious/androecious) individuals, is rare in flowering plants. This rarity may be a result of the frequent transition from dioecy into systems with co-sexual individuals.
Peng Sun, Soichiro Nishiyama, Huawei Li, Yini Mai, Weijuan Han, Yujing Suo, Chengzhi Liang, Huilong Du, Songfeng Diao, Yiru Wang, Jiaying Yuan, Yue Zhang, Ryutaro Tao, Fangdong Li, Jianmin Fu   +14 more
doaj   +1 more source