Results 71 to 80 of about 40,064,637 (293)
Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies candidate susceptibility genes for breast and ovarian cancer
HGG Advances, 2021 Summary: Familial, sequencing, and genome-wide association studies (GWASs) and genetic correlation analyses have progressively unraveled the shared or pleiotropic germline genetics of breast and ovarian cancer.Siddhartha P. Kar, Daniel P.C. Considine, Jonathan P. Tyrer, Jasmine T. Plummer, Stephanie Chen, Felipe S. Dezem, Alvaro N. Barbeira, Padma S. Rajagopal, Will T. Rosenow, Fernando Moreno, Clara Bodelon, Jenny Chang-Claude, Georgia Chenevix-Trench, Anna deFazio, Thilo Dörk, Arif B. Ekici, Ailith Ewing, George Fountzilas, Ellen L. Goode, Mikael Hartman, Florian Heitz, Peter Hillemanns, Estrid Høgdall, Claus K. Høgdall, Tomasz Huzarski, Allan Jensen, Beth Y. Karlan, Elza Khusnutdinova, Lambertus A. Kiemeney, Susanne K. Kjaer, Rüdiger Klapdor, Martin Köbel, Jingmei Li, Clemens Liebrich, Taymaa May, Håkan Olsson, Jennifer B. Permuth, Paolo Peterlongo, Paolo Radice, Susan J. Ramus, Marjorie J. Riggan, Harvey A. Risch, Emmanouil Saloustros, Jacques Simard, Lukasz M. Szafron, Linda Titus, Cheryl L. Thompson, Robert A. Vierkant, Stacey J. Winham, Wei Zheng, Jennifer A. Doherty, Andrew Berchuck, Kate Lawrenson, Hae Kyung Im, Ani W. Manichaikul, Paul D.P. Pharoah, Simon A. Gayther, Joellen M. Schildkraut +57 moredoaj +1 more sourceGenome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1 [PDF]
, 2011 Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10% in the general population above 65 years of age. Affected individuals suffer from uncomfortable sensations and an urge to move in the lower limbs that ...Juliane Winkelmann, Sona Nevsimalova, Dauvilliers, Yves, Bachmann, Cornelius G., Wichmann, H. -Erich, Knauf F, Wichmann HE, Gschliesser V, Kettunen Johannes, Fontaine, B., Vávrová J, Müller-Myhsok, B., Montplaisir Jacques, Ondo, William, G., Czamara, D., Le Wei-Dong, Bertram Müller-Myhsok, Schulte, E.C., Birgit Högl, Fietze Ingo, Stiasny-Kolster, Karin, Kettunen, Johannes, Kaffe M, Müller Myhsok B, Vodicka, P., H.-Erich Wichmann, Vilariño-Güell, Carles, Wichmann, H.-E., Gschliesser, V., Perola Markus, Xiong, L., Illig Thomas, Silander, K., Fontenille C, Berger K, Bertram Müller-Myhsok, Berger, K., Cournu Rebeix I, Kaffe, Maria, Sonka K, Faraco J, Mueller-Myhsok, Bertram, Maria Kaffe, Sonka, K., Müller-Myhsok Bertram, Earley CJ, Cournu-Rebeix Isabelle, Kemlink David, Stiasny Kolster K, Vilariño-Güell Carles, Poewe Werner, Kaffe Maria, Ondo William G., Lichtner, P., Zimprich A, Fietze, I., Fontaine Bertrand, Bachmann, C.G., Farrer, Matthew J., Olli Polo, Allen, R. P., Vavrova, J., Hoegl, Birgit, Cournu-Rebeix, I., Oertel Wolfgang, Högl Birgit, Kettunen J, Zimprich, A., Meitinger, T., Fontaine, Bertrand, Högl, B., Richard P. Allen, Faraco, J., William G. Ondo, Lin Siong-Chi, Oertel, Wolfgang, Allen, Richard P., Meitinger T., Fuhs, Andrea, Cornelius G. Bachmann, Wichmann, H-Erich, Wszolek Zbigniew, Perola M, Polo, Olli, Meitinger Thomas, Darina Czamara, Xiong L, Siong-Chi Lin, Allen, R., Knauf, F., Le, Wei-Dong, Gross Nadine, Bachmann, C., Gieger, C., Berger, Klaus, Cournu-Rebeix, Isabelle, Matthew J Farrer, Paulus Walter, Peppard P, Stiasny-Kolster, K., Winkelmann, Juliane, Fietze I, Francavilla Marcella, Schulte, Eva C., Carles Vilariño-Güell, Walter Paulus, Christopher J Earley, Dauvilliers Y, Gieger C, Werner Poewe, Gieger Christian, Frauscher Birgit, Bachmann CG, Wolfgang Oertel, Ondo, W.G., Schulte EC, Bachmann, C. G., Guy A Rouleau, Falkenstetter Tina, Klaus Berger, Trenkwalder C, Earley, Christopher J., Fontenille, Claire, Faraco, Juliette, Prokisch, Holger, Lin, S. C., Juliette Faraco, Paulus, Walter J., Farrer Matthew J., Bertrand Fontaine, Schulte, E., Paulus, W., Ondo, W., Montplaisir, Jacques, Paul Peppard, Trenkwalder Claudia, Illig T, Dauvilliers, Y., Schulte Eva C., Wichmann, H., Thomas Illig, Silander, Kaisa, Winkelmann, J., Paulus W, Johannes Kettunen, Spieler D, Jacques Montplaisir, Peppard Paul, Frauscher B, Earley, C., Zimprich, Alexander, Alexander Zimprich, Falkenstetter, T., Le WD, Fontenille Claire, Rouleau, G.A., Czamara, Darina, Schormair, Barbara, Vodicka P, Spieler, Derek, Karel Sonka, William G Ondo, Paulus, Walter, Peppard, P., Wichmann, H. E., Le, W. D., Guy A. Rouleau, Frauscher, B., Montplaisir, J., Trenkwalder, Claudia, Marcella Francavilla, Le, W.D., Vilarino-Guell, C., Lin, S., Vilariño Güell C, Poewe, W., Le, W., Prokisch Holger, Fuhs, A., Högl B, Lichtner Peter, Wszolek, Z., Sonka Karel, Wei-Dong Le, Illig, T., Earley, Christopher, J., Schulte, E. C., Fontaine B, Vodicka Pavel, Mignot Emmanuel, Kaffe, M., Faraco Juliette, Barbara Schormair, Christopher J. Earley, Francavilla, M., Kaisa Silander, Xiong, Lan, Schormair B, Ingo Fietze, Prokisch, H., Gschliesser, Viola, Viola Gschliesser, Yves Dauvilliers, Mignot, Emmanuel, Emmanuel Mignot, Kemlink, D., Peter Lichtner, Polo O, Lichtner, Peter, Rouleau, Guy, A., Allen Richard P., Czamara D, Schulte, Eva, C., Karin Stiasny-Kolster, Knauf, Franziska, H-Erich Wichmann, Mignot, E., Lin, Siong-Chi, Zbigniew Wszolek, Perola, Markus, Müller-Myhsok, Bertram, Tina Falkenstetter, Rouleau, Guy A., Gieger, Christian, Ondo, W. G., Fietze, Ingo, Nevsimalova Sona, Lan Xiong, David Kemlink, Derek Spieler, Carles Vilariño-Güell, Zimprich Alexander, Allen RP, Earley, C. J., Eva C Schulte, Nevsimalova, Sona, Earley, C.J., Farrer, Matthew, J., Czamara Darina, Lin, S.C., Richard P Allen, Allen, R.P., Wichmann, Heinz-Erich, Montplaisir J, Gross, N., Poewe W, Allen, Richard, P., Vávrová Jana, Prokisch H, Christian Gieger, Francavilla, Marcella, Vavrova, Jana, Franziska Knauf, Matthew J. Farrer, Dauvilliers Yves, Rouleau Guy A., Farrer, M. J., Ondo WG, Gross, Nadine, Rouleau GA, Wszolek Z, Schormair Barbara, Falkenstetter T, Eva C. Schulte, Kemlink, David, Ondo, William G., Bachmann, Cornelius, G., Sonka, Karel, Kemlink D, Nevsimalova, S., Andrea Fuhs, Cornelius G Bachmann, Trenkwalder, C., Oertel, W., Farrer MJ, Falkenstetter, Tina, Poewe, Werner, Högl, Birgit, Bachmann Cornelius G., Wichmann H.-Erich, Schormair, B., Claudia Trenkwalder, Xiong Lan, Polo, O., Oertel W, Markus Perola, Farrer, M., Perola, M., Silander Kaisa, Polo Olli, Stiasny-Kolster Karin, Isabelle Cournu-Rebeix, Winkelmann J, Mignot E, Gschliesser Viola, Fontenille, C., Frauscher, Birgit, Nadine Gross, Berger Klaus, Illig, Thomas, Jana Vávrová, Meitinger, Thomas, Rouleau, G. A., Fuhs A, Winkelmann Juliane, Rouleau, G., Fuhs Andrea, Farrer, M.J., Earley Christopher J., Peppard, Paul, Birgit Högl, Vodicka, Pavel, Thomas Meitinger, Gross N, Birgit Frauscher, Spieler Derek, Lichtner P, Lin SC, Kettunen, J., Vilarino-Gueell, Carles, Pavel Vodicka, Spieler, D., Silander K, Wszolek, Zbigniew, Nevsimalova S, Claire Fontenille, Holger Prokisch, Knauf Franziska, Jana Vávrová, Rouleau, Guy,, Bachmann, Cornelius,, Schulte, Eva,, Earley, Christopher,, Farrer, Matthew,, Ondo, William,, Allen, Richard,, Winkelmann, J;Czamara, D;Schormair, B;Knauf, F;Schulte, EC;Trenkwalder, C;Dauvilliers, Y;Polo, O;Högl, B;Berger, K;Fuhs, A;Gross, N;Stiasny-Kolster, K;Oertel, W;Bachmann, CG;Paulus, W;Xiong, L;Montplaisir, J;Rouleau, GA;Fietze, I;Vávrová, J;Kemlink, D;Sonka, K;Nevsimalova, S;Lin, SC;Wszolek, Z;Vilarino-Guell, C;Farrer, MJ;Gschliesser, V;Frauscher, B;Falkenstetter, T;Poewe, W;Allen, RP;Earley, CJ;Ondo, WG;Le, WD;Spieler, D;Kaffe, M;Zimprich, A;Kettunen, J;Perola, M;Silander, K;Cournu-Rebeix, I;Francavilla, M;Fontenille, C;Fontaine, B;Vodicka, P;Prokisch, H;Lichtner, P;Peppard, P;Faraco, J;Mignot, E;Gieger, C;Illig, T;Wichmann, HE;Müller-Myhsok, B;Meitinger, T +336 morecore +2 more sourcesEpigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan +4 morewiley +1 more sourceLigand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada +5 morewiley +1 more sourceGenome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke [PDF]
, 2012 Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of ...Furie, K., Seedorf, Udo, Cathie L M Sudlow, Spencer, C.C.A., Woo, D., Müller-Myhsok, B., Jackson, C. A., Sawcer, SJ, Markus, Hugh S, Lindgren, Arne,, Segal, H, Viswanathan, Ananth C., Syme, P. D., Valerie Valant, Rautanen, A, Matthew Traylor, Gray, E, Sarah Edkins, Attia, J., Palmer, C., Rothwell, Peter M., Juan P Casas, Levi, Chris, Worrall, Bradford B, Levi, C., Jankowski, J., Peltonen, L, Palmer, Colin N. A., Sawcer, S., Edkins, Sarah, Delavaran, Hossein,, Kissela, Brett, Pankaj Sharma, WTCCC2, Sharma, P, Goel, A, Gray, E., Joanna Pera, Palmer, CN, Boonen, S., Worrall, BB, Dorota Wloch-Kopec, Cordelia Langford, Helgadottir, A, Steve Bevan, Su, Zhan, Rothwell, Peter M, Sudlow, Cathie LM, Wellcome Trust Case Control Consortium 2 (WTCCC2) (), Bradford B Worrall, Viswanathan, A.C., Hossein Delavaran, Valant, V., Nalls, Michael A., Stefansson, K, Donnelly, P, Palmer, Colin NA, Worrall, B., Wloch-Kopec, D., Martin Farrall, Elvira Bramon, Lindgren, Arne, Valant, V, Kittner, Steven J., Corvin, A., Syme, PD, Meisinger, Christa, Schanz, R., Delavaran, H, Goel, Anuj, Audrey Duncanson, Unnur Thorsteinsdottir, Syme, P.D., Bramon, E, Stephen J Sawcer, Pirinen, Matti, Burgess, A., Kissela, B., Cheng, Y., Helen Segal, Cheng, YC, Meschia, JF, Edkins, S., Levi, C, Parati, E. A., Rainer Malik, Meschia, J., Trembath, R., Cortellini, L., Burgess, AI, Trembath, RC, ?, ?, Langford, C, Boncoraglio, G. B., Bevan, S, Poole, D, International Store Genetics Consortium, Burgess, A.I., Spencer, Chris CA, Spencer, Chris, Nalls, M.A., Bellenguez, C., Matthew Walters, Traylor, M, Boncoraglio, G.B., Attia, John, Freeman, Colin, Jackson, Caroline; id_orcid, Lemmens, Robin, Spencer, Chris C. A., Sudlow, Cathie L M, Ross-Adams, H., Thijs, V, Gray, Emma, Hugh S Markus, Dichgans, M, Nicholas W Wood, Wellcome Trust Case Control Consortium 2 (WTCCC2), Brown, MA, Norrving, Bo,, Wood, N.W., Brown, M., Burgess, Annette I, International Stroke Genetics Consortium (Meisinger, C.), Emma Gray, Mitchell, BD, Colin Freeman, Giorgio B Boncoraglio, Norrving, B., Franzosi, MG, James, T., Slark, Julia, Mitchell, B., Murphy, Lee, Wood, N. W., Goel, A., Julia Slark, Seedorf, U, Boonen, S, Udo Seedorf, Boonen, Steven, Sharma, Pankaj, Deborah Poole, Rothwell, PM, Casas, J., Su, Z., Edkins, S, Cheng, Yu-Ching, Colin N A Palmer, Franzosi, M., Lund University., Lee Murphy, Elizabeth Holliday, Wood, Nicholas W, Rothwell, P., Viswanathan, Ananth C, Norrving, Bo, Anuj Goel, Tom James, Casas, J. P., Gretarsdottir, S., Sarah Hunt, Sudlow, C.L.M., Gschwendtner, A., Bevan, Steve, Deloukas, P., Müller-Myhsok, Bertram, Janusz Jankowski, Yu-Ching Cheng, Macleod, M.J., Dronov, S, Slowik, A, Walters, Matthew, Meschia, James F, Pera, J, Plomin, R, Spencer, CCA, Casas, JP, Brown, Matthew A, Mathew, Christopher G., Peltonen L, Holliday, E., Slowik, A., Bramon, Elvira, Plomin, Robert, Cheng, Y. C., Band, G., Thorsteinsdottir, U, Helen Ross-Adams, Sudlow, C., Strange, A, Band, Gavin, Markus, H.S., Wellcome Trust Control Consortium, Rautanen, A., Nalls, Michael A, Worrall, B. B., Blackwell, J. M., Casas, Juan P., Deloukas, Panos, Macleod, MJ, Thijs, Vincent, Spencer, C., Ananth C Viswanathan, Traylor, M., Duncanson, A., Poole, Deborah, Bramon, E., Wloch-Kopec, D, Spencer, CC, Holliday, E, Macleod, Mary Joan, Band, G, Palmer, CNA, Bevan, S., Viswanathan, AC, Poole, D., Schanz, R, Macleod, M., Palmer, C. N. A., Meisinger, C., Furie, Karen, Viswanathan, A., Woo, Daniel, Delavaran, H., Dronov, S., International Stroke Genetics Consortium (ISGC), Anna Helgadottir, Kissela, B, Corvin, Aiden, Sudlow, CL, Casas, J.P., Annette I Burgess, Markus, H. S., Helgadottir, Anna, Panos Deloukas, Jackson, C., Jackson, Caroline A., Mitchell, Braxton D., Walters, M., Bertram Müller-Myhsok, Franzosi, M-G, Bo, N, Donnelly, P., Burgess, A. I., Andreas Gschwendtner, Deloukas, P, Rosand, Jonathan, Gavin Band, Langford, C., Vincent Thijs, Sawcer, Stephen J, Cortellini, L, Delavaran, Hossein, Solveig Gretarsdottir, Peltonen, L., Burgess, Annette I., Wood, N., Lemmens, R, Mueller-Myhsok, Bertram, Parati, E.A., Franzosi, M. G., Farrall, M, Segal, H., Corvin, A, Kittner, Steven J, Mathew, Christopher G.; id_orcid, Sudlow, Catherine; id_orcid, Valant, Valerie, Hunt, S., Leena Peltonen, Palmer, C.N.A., Franzosi, Maria-Grazia, Mary Joan Macleod, Segal, Helen, Wood, Nicholas W., Arne Lindgren, Hunt, S, Bellenguez, Céline, Daniel Woo, Kari Stefansson, Rothwell, P.M., Furie, K, Matti Pirinen, Murphy, L, Céline Bellenguez, Dichgans, M., Boncoraglio, Giorgio B, Peter M Rothwell, Blackwell, Jenefer M., Christopher G Mathew, Duncanson, A, Jonathan Rosand, Trembath, Richard C, Sudlow, CLM, Chris C A Spencer, Pera, Joanna, Nalls, M. A., Meisinger, C, Rosand, J., James F Meschia, Palmer, Colin N A, Gudmar Thorleifsson, Wloch-Kopec, Dorota, Robin Lemmens, Agnieszka Slowik, Markus, H., Lemmens, R., Slark, J., Kittner, S. J., Boncoraglio, Giorgio B., Viswanathan, A. C., Cortellini, Lynelle, Peltonen, Leena, Sawcer, Stephen J., Seedorf, U., Parati, E., Peter Donnelly, Serge Dronov, Worrall, Bradford B., Mitchell, Braxton D, Malik, R., Boncoraglio, GB, Strange, Amy, Lindgren, A, Caroline A Jackson, Freeman, C., Thorsteinsdottir, Unnur, Brown, M. A., Jenefer M Blackwell, Bo, N., Wood, NW, Langford, Cordelia, Ross-Adams, Helen, Parati, Eugenio A, Hunt, Sarah, Stefansson, K., Blackwell, Jenefer M, Boncoraglio, G., Markus, HS, Rosand, J, Jackson, Caroline A, Norrving, B, Dronov, Serge, Anna Rautanen, Farrall, M., Jackson, CA, Sudlow, C. L. M., Thorleifsson, G, Malik, R, Slowik, Agnieszka, Lindgren, A., Amy Strange, Mathew, C., Renata Schanz, James, Tom, Ross-Adams, H, Matthew A Brown, Farrall, Martin, Syme, Paul D, Schanz, Renata, Mathew, CG, Helgadottir, A., Donnelly, Peter, Brett Kissela, Stefansson, Kari, Pirinen, M., Sharma, P., Mathew, Christopher G, Martin Dichgans, Nalls, M., Zhan Su, Parati, EA, Attia, J, Gretarsdottir, Solveig, Trembath, Richard C., Kittner, S., Pirinen, M, Nalls, MA, Cheng, Y-C, Müller-Myhsok, B, Strange, A., Blackwell, JM, Slark, J, Sudlow, Cathie L. M., Thorsteinsdottir, U., Kittner, S.J., Mathew, C. G., Su, Z, Plomin, R., Kittner, SJ, Spencer, Chris C A, Jackson, C.A., Worrall, B.B., Casas, Juan P, Gschwendtner, Andreas, Dichgans, Martin, Blackwell, J., Thorleifsson, G., Michael A Nalls, Gschwendtner, A, Macleod, M. J., Aiden Corvin, Eugenio A Parati, Murphy, L., Rautanen, Anna, Thorleifsson, Gudmar, Jankowski, Janusz, Freeman, C, Syme, P., Sawcer, S.J., Meschia, J. F., Steven J Kittner, John Attia, Brown, Matthew A., Rothwell, P. M., Syme, Paul D., ISGC, Parati, Eugenio A., Markus HS, Robert Plomin, James, T, Walters, M, Mitchell, B. D., Bo Norrving, Trembath, R. C., Meschia, J.F., Pera, J., Duncanson, Audrey, Mitchell, B.D., Woo, D, Spencer, C. C. A., Markus, Hugh S., Jankowski, J, Blackwell, J.M., Chris Levi, Thijs, V., Gretarsdottir, S, Christa Meisinger, Richard C Trembath, Holliday, Elizabeth, Steven Boonen, Mathew, C.G., Murphy, Lee; id_orcid, Bellenguez, C, Meschia, James F., Malik, Rainer, Braxton D Mitchell, Sawcer, S. J., Traylor, Matthew, Karen Furie, Trembath, R.C., Lynelle Cortellini, Maria-Grazia Franzosi, Paul D Syme, Palmer, Colin N. A.; id_orcid +455 morecore +2 more sources‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...Jack P. K. Bravowiley +1 more source
