Results 51 to 60 of about 41,997,054 (284)

Transcriptome-wide association study identifies genes associated with bladder cancer risk. [PDF]

Sci Rep
AbstractGenome-wide association studies (GWAS) have detected several susceptibility variants for urinary bladder cancer, but how gene regulation affects disease development remains unclear. To extend GWAS findings, we conducted a transcriptome-wide association study (TWAS) using PrediXcan to predict gene expression levels in whole blood using genome ...
Li S, Gui J, Karagas MR, Passarelli MN.
europepmc   +4 more sources

Transcriptome-wide association studies accounting for colocalization using Egger regression [PDF]

Genetic Epidemiology, 2017
Abstract Integrating genome-wide association (GWAS) and expression quantitative trait locus (eQTL) data into transcriptome-wide association studies (TWAS) based on predicted expression can boost power to detect novel disease loci or pinpoint the susceptibility gene at a known disease locus.
Richard Barfield, Helian Feng, Alexander Gusev, Lang Wu, Wei Zheng, Bogdan Pasaniuc, Peter Kraft   +6 more
openaire   +3 more sources

Transcriptome-wide association and prediction for carotenoids and tocochromanols in fresh sweet corn kernels

, 2021
Sweet corn is consistently one of the most highly consumed vegetables in the U.S., providing a valuable opportunity to increase nutrient intake through biofortification.
University of Georgia (17856095)
core  

From Gene Expression to Transcriptome-wide Association Study: Development and Comparison of Methodology

Xiehe Yixue Zazhi
Over the past two decades, genome-wide association study(GWAS) has identified numerous genetic variants and loci associated with heritable diseases. With the gradual maturation and saturation of GWAS methodologies, transcriptome-wide association study ...
FANG Kun, LI Guozhuang, WANG Linting, LI Qing, XU Kexin, ZHAO Lina, WU Zhihong, ZHANG Jianguo, WU Nan   +8 more
doaj   +1 more source

supplemental data for manuscript Genome wide association studies and transcriptome changes during acclimation

, 2020
supplemental data for manuscript Genome wide association studies and transcriptome changes during ...
David Horvath
core   +1 more source

Identification and validation of novel risk genes for intervertebral disc disorder by integrating large-scale multi-omics analyses and experimental studies

Frontiers in Medicine
IntroductionAlthough genome-wide association studies (GWAS) have identified multiple genetic loci linked to intervertebral disc disorder (IDD), their functional characterization remains largely unelucidated.
Zhe Zhang, Zhe Zhang, Yu Chen, Qianjin Wang, Zheng Li, Bingyang Dai, Bingyang Dai, Cheng Dong, Cheng Dong, Zhengya Zhu   +9 more
doaj   +1 more source

A transcriptome-wide association study provides new insights into the etiology of osteoarthritis

Annals of Translational Medicine, 2022
Osteoarthritis (OA) is a common clinical disease caused by a variety of factors, including genetic variants. Although genome-wide association studies (GWAS) have been performed to elucidate the genetic basis of OA, some loci of risk located in noncoding regions of the genome have been neglected.
Wang, Weiwei, Ou, Zhixue, Peng, Jianlan, Zhou, Yi, Wang, Ning   +4 more
openaire   +2 more sources

Genome-wide association study of receptive language ability of 12 year olds [PDF]

, 2013
Purpose: We have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. The current study attempted to identify some of the genes responsible for the heritability of receptive language ...
Hanscombe, K.B., Meaburn, Emma L, Dale, Philip S, Plomin, Robert, Hayiou-Thomas, Marianna E, Jankowski, Janusz, Haworth, Claire M.A., Trzaskowski, M., Haworth, C., Haworth, Claire M. A., Hayiou-Thomas, Marianna E., Wellcome Trust Case Control Consortium (including Jankowski J), Harlaar, N., Haworth, Claire M A, Dale, Philip S., Dale, P., Harlaar, Nicole, Price, T.S, Price, Thomas S, Docherty, Sophia, Hayiou-Thomas, M.E., Davis, Oliver S. P., Plomin, R., Meaburn, Emma L., Price, Tom S., HASH(0x55a67fe4f3e8), Hanscombe, Ken B., ?, ?, Davis, O.S.P., Docherty, S.J., Price, Thomas S., Trzaskowski, Maciej, Davis, Oliver S P   +32 more
core   +1 more source

Integrating multiple omics approaches to identify AIF1 as a protective factor in IgA nephropathy

Journal of Translational Autoimmunity
IgA nephropathy (IgAN) is the most prevalent primary glomerular disease worldwide, and its diagnosis still relies on invasive kidney biopsy. To identify noninvasive biomarkers and therapeutic targets, we applied a multi-ancestry Mendelian randomization ...
Xingyu Liu, Yiyang Hu, Wenjia Zhang, Chaohong Nie, Fengxia Zhang, Yufeng Liu, Xiaoyan Su, Shuangxin Liu, Quhuan Li   +8 more
doaj   +1 more source

Integrating Genome-Wide Association Studies and Gene Expression Profiles With Chemical-Genes Interaction Networks to Identify Chemicals Associated With Colorectal Cancer

Frontiers in Genetics, 2020
Colorectal cancer (CRC) is the third most common cancer and has the second highest mortality rate in global cancer. Exploring the associations between chemicals and CRC has great significance in prophylaxis and therapy of tumor diseases.
Xinyue Tan, Hanmin Tang, Liuyun Gong, Lina Xie, Yutiantian Lei, Zhenzhen Luo, Chenchen He, Jinlu Ma, Suxia Han   +8 more
doaj   +1 more source