Results 41 to 50 of about 41,997,054 (284)
, 2022 Genome-wide association studies (GWAS) have been utilized to find associations between single nucleotide polymorphisms (SNPs) and traits. However, most GWAS are conducted on populations of European ancestries. Further analysis involving the transcriptome
Nguyen, Christopher +2 more
core +1 more source
Frontiers in Genetics, 2021 BackgroundAcute myocardial infarction (AMI), characterized by an event of myocardial necrosis, is a common cardiac emergency worldwide. However, the genetic mechanisms of AMI remain largely elusive.MethodsA genome-wide association study dataset of AMI ...
Guanzhong Chen +22 more
doaj +1 more source
Multi-ethnic transcriptome-wide association study of prostate cancer
PLOS ONE, 2020 Abstract The genetic risk for prostate cancer has been governed by a few rare variants with high penetrance and over 150 commonly occurring variants with lower impact on risk; however, most of these variants have been identified in studies containing exclusively European individuals.
Peter N. Fiorica +4 more
openaire +4 more sources
A powerful fine-mapping method for transcriptome-wide association studies [PDF]
Human Genetics, 2019 Transcriptome-wide association studies (TWAS) have been recently applied to successfully identify many novel genes associated with complex traits. While appealing, TWAS tend to identify multiple significant genes per locus, and many of them may not be causal due to confounding through linkage disequilibrium (LD) among SNPs. Here we introduce a powerful
Chong Wu, Wei Pan
openaire +2 more sources
A transcriptome-wide association study identifies susceptibility genes for Parkinson’s disease [PDF]
npj Parkinson's Disease, 2021 AbstractGenome-wide association study (GWAS) has seen great strides in revealing initial insights into the genetic architecture of Parkinson’s disease (PD). Since GWAS signals often reside in non-coding regions, relatively few of the associations have implicated specific biological mechanisms.
Shi Yao +9 more
openaire +3 more sources
Transcriptome-wide association study of inflammatory biologic age
Aging, 2017 Chronic low grade inflammation is a fundamental mechanism of aging. We estimated biologic age using nine biomarkers from diverse inflammatory pathways and we hypothesized that genes associated with inflammatory biological age would provide insights into human aging. In Framingham Offspring Study participants at examination 8 (2005 to 2008), we used the
Lin, Honghuang +9 more
openaire +4 more sources
A Framework for Transcriptome-Wide Association Studies in Breast Cancer in Diverse Study Populations [PDF]
Genome Biology, 2019 Abstract Background The relationship between germline genetic variation and breast cancer survival is largely unknown, especially in understudied minority populations who often have poorer survival.
Bhattacharya, Arjun +5 more
openaire +3 more sources
A transcriptome-wide association study of high-grade serous epithelial ovarian cancer identifies new susceptibility genes and splice variants. [PDF]
, 2019 We sought to identify susceptibility genes for high-grade serous ovarian cancer (HGSOC) by performing a transcriptome-wide association study of gene expression and splice junction usage in HGSOC-relevant tissue types (N = 2,169) and the largest genome ...
Liu, Gang +35 more
core +5 more sources
Integrative analysis of transcriptome-wide association study and gene expression profiling identifies candidate genes associated with stroke [PDF]
PeerJ, 2019 Background Stroke is a major public health burden worldwide. Although genetic variation is known to play a role in the pathogenesis of stroke, the specific pathogenic mechanisms are still unclear.
Jian Yang +10 more
doaj +2 more sources
Frontiers in Immunology, 2022 This study aimed to identify susceptibility genes and pathways associated with ankylosing spondylitis (AS) by integrating whole transcriptome-wide association study (TWAS) analysis and mRNA expression profiling data.
Ruoyang Feng +4 more
doaj +1 more source