Results 41 to 50 of about 40,064,637 (293)

Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology [PDF]

open access: yes, 2022
To identify genetic determinants of airway dysfunction, we performed a transcriptome-wide association study for asthma by combining RNA-seq data from the nasal airway epithelium of 681 children, with UK Biobank genetic association data.
Fairbanks-Mahnke, Ana   +38 more
core   +1 more source

A powerful fine-mapping method for transcriptome-wide association studies [PDF]

open access: yesHuman Genetics, 2019
Transcriptome-wide association studies (TWAS) have been recently applied to successfully identify many novel genes associated with complex traits. While appealing, TWAS tend to identify multiple significant genes per locus, and many of them may not be causal due to confounding through linkage disequilibrium (LD) among SNPs. Here we introduce a powerful
Chong Wu, Wei Pan
openaire   +2 more sources

A transcriptome-wide association study identifies susceptibility genes for Parkinson’s disease [PDF]

open access: yesnpj Parkinson's Disease, 2021
AbstractGenome-wide association study (GWAS) has seen great strides in revealing initial insights into the genetic architecture of Parkinson’s disease (PD). Since GWAS signals often reside in non-coding regions, relatively few of the associations have implicated specific biological mechanisms.
Shi Yao   +9 more
openaire   +3 more sources

Genome-wide association and functional follow-up reveals new loci for kidney function [PDF]

open access: yes, 2012
Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new
Döring, Angela   +999 more
core   +2 more sources

Transcriptome-wide association study of inflammatory biologic age

open access: yesAging, 2017
Chronic low grade inflammation is a fundamental mechanism of aging. We estimated biologic age using nine biomarkers from diverse inflammatory pathways and we hypothesized that genes associated with inflammatory biological age would provide insights into human aging. In Framingham Offspring Study participants at examination 8 (2005 to 2008), we used the
Lin, Honghuang   +9 more
openaire   +4 more sources

A Framework for Transcriptome-Wide Association Studies in Breast Cancer in Diverse Study Populations [PDF]

open access: yesGenome Biology, 2019
Abstract Background The relationship between germline genetic variation and breast cancer survival is largely unknown, especially in understudied minority populations who often have poorer survival.
Bhattacharya, Arjun   +5 more
openaire   +3 more sources

Integrative analysis of transcriptome-wide association study and gene expression profiling identifies candidate genes associated with stroke [PDF]

open access: yesPeerJ, 2019
Background Stroke is a major public health burden worldwide. Although genetic variation is known to play a role in the pathogenesis of stroke, the specific pathogenic mechanisms are still unclear.
Jian Yang   +10 more
doaj   +2 more sources

Transcriptome-Wide Association Studies and Integration Analysis of mRNA Expression Profiles Identify Candidate Genes and Pathways Associated With Ankylosing Spondylitis

open access: yesFrontiers in Immunology, 2022
This study aimed to identify susceptibility genes and pathways associated with ankylosing spondylitis (AS) by integrating whole transcriptome-wide association study (TWAS) analysis and mRNA expression profiling data.
Ruoyang Feng   +4 more
doaj   +1 more source

Transcriptome-wide association study identifies genes associated with bladder cancer risk. [PDF]

open access: yesSci Rep
AbstractGenome-wide association studies (GWAS) have detected several susceptibility variants for urinary bladder cancer, but how gene regulation affects disease development remains unclear. To extend GWAS findings, we conducted a transcriptome-wide association study (TWAS) using PrediXcan to predict gene expression levels in whole blood using genome ...
Li S, Gui J, Karagas MR, Passarelli MN.
europepmc   +4 more sources

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure [PDF]

open access: yes, 2011
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans1, 2, 3. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N =
Döring, Angela   +999 more
core   +2 more sources

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